Journal of Nanotechnology,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Using
carbon‐based
nanoparticles,
such
as
diamond,
graphite,
fullerene,
and
nanotubes,
has
increased
their
research
possible
strategies
for
drug
delivery
to
control
diseases,
especially
cancer.
However,
because
these
materials,
when
interacting
with
the
living
environment,
release
substances
that
are
capable
of
inducing
cell
death
by
themselves,
it
is
vital
importance
analyze
type
particle
can
induce.
Although
there
different
efforts
describe
kind
nanoparticles
used
treat
diseases
cancer,
no
paper
explains
mechanisms
induced
nanoparticle
systems.
Therefore,
this
attempts
gain
cutting‐edge
information
on
using
nanopolymorphisms
mechanism
particles
produce.
In
conclusion,
carbon
interact
directly
membranes,
causing
physical
damage
disturbing
integrity
membrane.
This
alteration
mainly
lead
necrosis
or
apoptosis.
The
definition
a
predominant
each
depends
dose‐dependent
manner.
Primarily,
concentrations
cytotoxicity
were
100–500
μg/mL.
several
studies
analyzed,
was
only
find
nanodiamonds
proved
not
be
cytotoxic.
Abstract
Machine
learning
(ML)
and
nanotechnology
interfacing
are
exploring
opportunities
for
cancer
treatment
strategies.
To
improve
therapy,
this
article
investigates
the
synergistic
combination
of
Graphene
Oxide
(GO)‐based
devices
with
ML
techniques.
The
production
techniques
functionalization
tactics
used
to
modify
physicochemical
characteristics
GO
specific
drug
delivery
explained
at
outset
investigation.
is
a
great
option
treating
because
its
natural
biocompatibility
capacity
absorb
medicinal
chemicals.
Then,
complicated
biological
data
analyzed
using
algorithms,
which
make
it
possible
identify
best
medicine
formulations
individualized
plans
depending
on
each
patient's
particular
characteristics.
study
also
looks
optimizing
predicting
interactions
between
carriers
cells
ML.
Predictive
modeling
helps
ensure
effective
payload
release
therapeutic
efficacy
in
design
customized
systems.
Furthermore,
tracking
outcomes
real
time
made
by
permit
adaptive
modifications
therapy
regimens.
By
medication
doses
settings,
not
only
decreases
adverse
effects
but
enhances
accuracy.
Cancer
is
a
daunting
global
health
problem
with
steadily
rising
incidence.
Despite
the
wide
arsenal
of
current
anticancer
therapies,
challenges
such
as
drug
resistance,
tumor
heterogeneity,
poor
targeting,
and
severe
side
effects
often
lead
to
suboptimal
efficacy
patient
outcomes,
highlighting
need
for
innovative
therapies.
Autophagy
modulation
has
emerged
an
attractive
approach
complement
existing
The
dual
role
autophagy
in
cancer
promotion
suppression
inspired
development
new
drugs
therapeutic
strategies
focusing
on
both
inhibition
induction.
promising
results
modulators
preclinical
studies,
lack
selectivity
potency,
toxicity,
pharmacokinetics,
inadequate
targeting
continue
limit
their
successful
clinical
translation.
Many
these
could
be
overcome
using
nanomedicine.
This
review
explores
recent
advancements
nanomedicine
modulation.
Successful
combination
leveraging
nanoparticles
synergy
chemotherapy,
immunotherapy,
phototherapy,
gene
therapy,
other
modalities
are
presented.
Additionally,
nanomaterials
intrinsic
autophagy‐modulating
capabilities,
self‐assembling
inhibitors,
discussed.
Finally,
limitations
currently
trials
discussed,
future
perspectives
designing
implementation
explored.
Nanoscale Horizons,
Год журнала:
2024,
Номер
9(5), С. 799 - 816
Опубликована: Янв. 1, 2024
A
comparative
journey
into
biomolecular
corona
features
involving
proteomics,
lipidomics,
high
throughput
in
vitro
screening,
and
molecular
feature
analysis
to
investigate
the
vivo
/
bias
for
nanomaterials
testing
biology.
Abstract
Nonviral
vectors,
such
as
liposomes,
offer
potential
for
targeted
gene
delivery
in
cancer
therapy.
Liposomes,
composed
of
phospholipid
vesicles,
have
demonstrated
efficacy
nanocarriers
genetic
tools,
addressing
the
limitations
off‐targeting
and
degradation
commonly
associated
with
traditional
therapy
approaches.
Due
to
their
biocompatibility,
stability,
tunable
physicochemical
properties,
they
overcoming
challenges
therapy,
low
transfection
efficiency
poor
stability
biological
fluids.
Despite
these
advancements,
there
remains
a
gap
understanding
optimal
utilization
nanoliposomes
enhanced
treatment.
This
review
delves
into
present
state
carriers
tools
sheds
light
on
safeguard
payloads
facilitate
cell
internalization
alongside
evolution
smart
delivery.
The
linked
biocompatibility
factors
that
restrict
effectiveness
are
also
discussed
along
exploring
strategies
by
analyzing
recent
advancements
offering
future
directions.
