Journal of Liposome Research,
Год журнала:
2024,
Номер
34(4), С. 671 - 696
Опубликована: Март 23, 2024
Triple-negative
breast
Cancer
(TNBC)
is
one
of
the
deadliest
types,
making
up
about
20%
all
cancers.
Chemotherapy
traditional
manner
progressed
TNBC
treatment;
however,
it
has
a
short-term
result
with
high
reversibility
pace.
The
lack
targeted
treatment
limited
and
person-dependent
options
for
those
suffering
from
cautions
to
be
worst
type
cancer
among
patients.
Consequently,
appropriate
this
disease
considered
major
clinical
challenge.
Therefore,
various
methods
have
been
developed
treat
TNBC,
which
chemotherapy
most
common
well-known
approach
recently
studied.
Although
effective
are
chemotherapies,
they
often
accompanied
by
critical
limitations,
especially
specific
functionality.
These
lead
systematic
toxicity
and,
ultimately,
expansion
multidrug-resistant
(MDR)
cells.
finding
novel
efficient
techniques
enhance
targeting
an
essential
requirement.
Liposomes
demonstrated
that
method
drug
delivery;
large
number
liposome-based
delivery
systems
annually
developed,
small
just
received
authorization
application.
new
approaches
using
liposomes
target
their
structure
ligands
increase
therapeutic
efficiency
diminish
undesired
side
effects
on
body
tissues.
current
study
describes
recent
strategies
research
associated
functionalizing
liposomes'
different
as
carriers
in
treating
TNBCs
preclinical
stages.
Receptors,
Год журнала:
2024,
Номер
3(3), С. 323 - 361
Опубликована: Июль 3, 2024
Receptor-targeted
drug
delivery
has
been
extensively
explored
for
active
targeting
of
therapeutic
moiety
in
cancer
treatment.
In
this
review,
we
discuss
the
receptors
that
are
overexpressed
on
tumor
cells
and
have
potential
to
be
targeted
by
nanocarrier
systems
We
also
highlight
different
types
ligands
researchers
explored.
Our
discussion
covers
various
modalities,
including
small
molecules,
aptamers,
peptides,
antibodies,
cell-based
strategies,
focuses
clinical
developments.
Additionally,
article
highlights
challenges
arise
during
translation
nanocarrier-based
strategies.
It
provides
future
directions
improving
research
area
clinically
translatable
cancer-targeted
therapy
improve
treatment
efficacy
while
minimizing
toxicity.
Pharmaceutics,
Год журнала:
2024,
Номер
17(1), С. 36 - 36
Опубликована: Дек. 30, 2024
Liposome-based
drug
delivery
technologies
have
showed
potential
in
enhancing
medication
safety
and
efficacy.
Innovative
loading
release
mechanisms
highlighted
this
review
of
next-generation
liposomal
formulations.
Due
to
poor
kinetics
capacity,
conventional
liposomes
limited
clinical
use.
Scientists
developed
new
carrier
control
encapsulation
methods
address
these
limits.
Drug
can
be
optimized
by
creating
lipid
compositions
that
match
a
drug's
charge
hydrophobicity.
By
selecting
lipids
adding
co-solvents
or
surfactants,
scientists
increased
formulations
while
maintaining
stability.
Nanotechnology
has
also
created
multifunctional
with
triggered
personalized
delivery.
Surface
modification
like
PEGylation
ligand
conjugation
direct
disease
regions,
improving
therapeutic
efficacy
reducing
off-target
effects.
In
addition
loading,
researchers
focused
on
spatiotemporal
modulation
release.
Stimuli-responsive
drugs
response
bodily
signals.
Liposomes
pH-
temperature-sensitive.
To
improve
reduce
systemic
toxicity,
added
stimuli-responsive
components
membranes
precisely
kinetics.
Advanced
magnetic
targeting
ultrasound.
Pro
Drug,
RNA
approach
may
administration.
Magnetic
helps
aggregate
at
illness
sites
improves
delivery,
whereas
ultrasound-mediated
facilitates
on-demand
encapsulated
medicines.
This
covers
recent
preclinical
research
showing
the
promise
for
cancer,
infectious
diseases,
neurological
disorders
inflammatory
disorders.
The
transfer
innovative
from
lab
practice
involves
key
difficulties
such
scalability,
manufacturing
difficulty,
regulatory
Chemical Communications,
Год журнала:
2024,
Номер
60(19), С. 2591 - 2604
Опубликована: Янв. 1, 2024
Poly(ethylene
glycol)
(PEG)
particles
can
be
prepared
using
templating
and
self-assembly
methods
endowed
with
stealth
targeting
properties
for
targeted
drug
delivery.
Advanced Materials,
Год журнала:
2024,
Номер
36(26)
Опубликована: Апрель 11, 2024
Combining
immune
checkpoint
blockade
with
chemotherapy
through
nanotechnology
is
promising
in
terms
of
safety
and
efficacy.
However,
the
distinct
subcellular
distribution
each
ingredient's
action
site
makes
it
challenging
to
acquire
an
optimal
synergism.
Herein,
a
dual-pH
responsive
hybrid
polymeric
micelle
system,
HNP(αPDL1
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Июнь 12, 2024
Abstract
Photoresponsive
drug
delivery
systems
(PDDSs)
have
emerged
as
a
promising
toolbox
for
delivery,
offering
precise
control
over
the
site,
duration,
and
dosage
of
light‐triggered
medication.
It
allows
controlled
release,
photo‐triggered
targeting,
diagnosis,
treatment,
improving
precision
efficacy
therapies
various
diseases.
Despite
progress
in
designing
different
PDDSs,
clinical
translation
has
been
limited
due
to
obstacles.
Herein,
this
review
article
focuses
on
three
critical
challenges
PDDSs:
1)
accumulation
at
diseased
lesions,
2)
light
irradiation,
3)
penetration
tissues.
Also,
summarizes
discusses
current
advancements
strategies
address
these
challenges.
Overall,
it
emphasizes
need
clarify
from
bench
bedside
develop
enhance
therapeutic
outcomes,
increase
compatibility
patient
compliance,
unlock
possibilities
therapies.
ACS Applied Nano Materials,
Год журнала:
2023,
Номер
6(23), С. 21462 - 21495
Опубликована: Ноя. 29, 2023
The
concept
of
theranostics
is
ground
breaking
in
the
area
cancer
remedy
due
to
its
capability
integrate
both
therapeutic
and
diagnostic
elements
a
single
approach.
This
approach
advantageous
diagnose
assess
treatment
simultaneously
enabling
identification
optimum
course.
process
includes
real-time
monitoring
strategies
through
simultaneous
delivery
imaging
agents.
Nanocarriers
or
nanomaterials
play
vital
role
theranostic
applications
therapy.
dual
task
provides
various
challenges.
Imaging
modalities
are
engineered
enhance
signal-to
noise
ratios
while
being
rapidly
eliminated.
high-concentration
accumulation
curatives
at
site
disease
biocompatibility
nanocarriers
two
important
concerns
considered
for
design
nanostructures.
Various
have
been
integrated
with
other
materials
form
composite
efficacy
along
diagnosing
ability.
In
this
report,
overview
metal,
ceramic,
polymer,
small-molecule-based
nanoparticulate
systems
presented
applications.
Russian Journal of General Chemistry,
Год журнала:
2023,
Номер
93(7), С. 1867 - 1899
Опубликована: Июль 1, 2023
Abstract
The
review
focuses
on
the
lipid
based
nanocarriers,
with
special
attention
paid
to
natural
bioactive
payloads.
First,
micelles
and
microemulsions
are
considered
as
very
attractive
colloidal
nanocontainers
that
allow
for
marked
improving
solubility
of
hydrophobic
bioactives.
Further,
liposomal
vehicles
reviewed,
both
advantages
limitations
discussed.
Literature
assay
covers
up-to-date
information
about
last
three
five
years,
although
brief
background
is
given
pioneer
works
addressing
liposomes
their
evolution
from
bench
bedside.
Final
part
devoted
modern
modifications
vesicular
nanocarriers
which
can
be
adapted
specific
administration
way
due
improved
targeting
properties,
permeability,
mucoadhesiveness
possibility
cross
biological
barriers.
Therein,
such
kinds
transfersomes,
niosomes,
ethosomes,
chitosomes
evaluated;
separate
sections
focus
formulations,
i.e.,
phytosomes
invasomes.
Nanomedicine,
Год журнала:
2024,
Номер
19(5), С. 431 - 453
Опубликована: Янв. 30, 2024
Cancer
cells
need
as
much
40-times
more
sugar
than
their
normal
cell
counterparts.
This
demand
is
attained
by
the
excessive
expression
of
inimitable
transporters
on
surface
cancer
cells,
driven
voracious
appetite
for
carbohydrates.
Nanotechnological
advances
drive
research
utilizing
ligand-directed
therapeutics
and
diverse
carbohydrate
analogs.
The
precise
delivery
these
therapeutic
cargos
not
only
mitigates
toxicity
associated
with
chemotherapy
but
also
reduces
grim
toll
mortality
morbidity
among
patients.
in-depth
review
explores
potential
ligands
in
advanced
treatment
using
nanoparticles.
It
offers
a
broader
perspective
beyond
usual
ways
we
deliver
drugs,
potentially
changing
way
fight
cancer.
