Role of mitochondrial alterations in human cancer progression and cancer immunity

Journal of Biomedical Science, Год журнала: 2023, Номер 30(1)

Опубликована: Июль 31, 2023

Abstract Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria are essential organelles responsible for numerous physiologic processes, such as energy production, metabolism, apoptosis, and calcium redox homeostasis. Although “Warburg effect,” in which cells prefer aerobic glycolysis even under normal oxygen circumstances, was proposed a century ago, how mitochondrial dysfunction contributes to progression still unclear. This review discusses recent progress alterations DNA (mtDNA) dynamics malignant progression. Moreover, we integrate possible regulatory mechanism dysfunction–mediated retrograde signaling pathways, including mitochondrion-derived molecules (reactive species, calcium, oncometabolites, mtDNA) stress response pathways (mitochondrial unfolded protein integrated response) provide therapeutic targets. Furthermore, discuss findings on role mitochondria immune function reveal impact tumor microenvironment remodeling immunity. Targeting might improve immunotherapy. These suggest that targeting malignancy modulating immunity be promising treatment strategies patients precise personalized medicine against cancer.

Язык: Английский

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Metformin-based nanomedicines for reprogramming tumor immune microenvironment

Theranostics, Год журнала: 2024, Номер 15(3), С. 993 - 1016

Опубликована: Дек. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Язык: Английский

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The Multifaceted Roles of NRF2 in Cancer: Friend or Foe?

Antioxidants, Год журнала: 2024, Номер 13(1), С. 70 - 70

Опубликована: Янв. 2, 2024

Physiological concentrations of reactive oxygen species (ROS) play vital roles in various normal cellular processes, whereas excessive ROS generation is central to disease pathogenesis. The nuclear factor erythroid 2-related 2 (NRF2) a critical transcription that regulates the antioxidant systems response oxidative stress by governing expression genes encoding enzymes shield cells from diverse alterations. NRF2 and its negative regulator Kelch-like ECH-associated protein 1 (KEAP1) have been focus numerous investigations elucidating whether suppresses tumor promotion or conversely exerts pro-oncogenic effects. has found participate pathological including dysregulated cell proliferation, metabolic remodeling, resistance apoptosis. Herein, this review article will examine intriguing role phase separation activating transcriptional activity explore dual impacts on immunology, cancer stem cells, metastasis, long non-coding RNAs (LncRNAs). Taken together, aims discuss multifaceted both prevention while also addressing advantages, disadvantages, limitations associated with modulating therapeutically treatment.

Язык: Английский

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Nanoplatform-enhanced photodynamic therapy for the induction of immunogenic cell death

Journal of Controlled Release, Год журнала: 2024, Номер 365, С. 1058 - 1073

Опубликована: Янв. 1, 2024

Язык: Английский

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Enhancing photodynamic immunotherapy by reprograming the immunosuppressive tumor microenvironment with hypoxia relief

Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 233 - 250

Опубликована: Фев. 29, 2024

Язык: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Язык: Английский

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A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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Cytoprotective Role of Heme Oxygenase-1 in Cancer Chemoresistance: Focus on Antioxidant, Antiapoptotic, and Pro-Autophagy Properties

Antioxidants, Год журнала: 2023, Номер 12(6), С. 1217 - 1217

Опубликована: Июнь 5, 2023

Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive oxygen species (ROS) manipulation is a promising strategy treatment since tumor cells present high levels of intracellular ROS, which makes them more vulnerable to further ROS elevation than normal cells. Nevertheless, dynamic redox evolution and adaptation are capable counteracting therapy-induced oxidative stress, leads chemoresistance. Hence, exploring cytoprotective mechanisms urgently needed overcome Heme oxygenase-1 (HO-1), rate-limiting enzyme heme degradation, acts as crucial antioxidant defense molecule response cellular stress. Recently, emerging evidence indicated that detoxification stress tolerance owing function HO-1 contribute chemoresistance various cancers. Enhanced expression or enzymatic activity was revealed promote apoptosis resistance activate protective autophagy, also involved development Moreover, inhibition multiple cancers identified reversing improving chemosensitivity. Here, we summarize most recent advances regarding antioxidant, antiapoptotic, pro-autophagy properties mediating chemoresistance, highlighting novel target for overcoming prognosis patients.

Язык: Английский

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Nanocatalytic Anti‐Tumor Immune Regulation

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(13)

Опубликована: Янв. 12, 2024

Abstract Immunotherapy has brought a new dawn for human being to defeat cancer. Although existing immunotherapy regimens (CAR‐T, etc.) have made breakthroughs in the treatments of hematological cancer and few solid tumors such as melanoma, therapeutic efficacy on most is still far from satisfactory. In recent years, researches tumor based nanocatalytic materials are under rapid development, significant progresses been made. Nanocatalytic medicine demonstrated be capable overcoming limitations current clinicnal by using toxic chemodrugs, exhibits highly attractive advantages over traditional therapies, enhanced sustained durable catalytic activity, remarkably reduced harmful side‐effects without so on. Most recently, introduced immune‐regulation disease treatments, especially, immunoactivation therapies. This article presents immune‐response activations medicine‐initiated chemical reactions immunotherapy, elucidates mechanism medicines regulating anti‐tumor immunity. By reviewing research progress emerging field, this review will further highlight great potential broad prospects nanocatalysis‐based immune‐therapeutics.

Язык: Английский

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Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(9), С. 3834 - 3854

Опубликована: Июнь 3, 2024

Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.

Язык: Английский

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