Biomarker Research,
Год журнала:
2024,
Номер
12(1)
Опубликована: Окт. 31, 2024
Copper
is
an
important
trace
element
for
maintaining
key
biological
functions
such
as
cellular
respiration,
nerve
conduction,
and
antioxidant
defense.
Maintaining
copper
homeostasis
critical
human
health,
its
imbalance
has
been
linked
to
various
diseases,
especially
cancer.
Cuproptosis,
a
novel
mechanism
of
copper-induced
cell
death,
provides
new
therapeutic
opportunities
metal
ion
regulation
interact
with
fate.
This
review
insights
into
the
complex
mechanisms
metabolism,
molecular
basis
cuproptosis,
association
cancer
development.
We
assess
role
cuproptosis-related
genes
(CRGs)
associated
tumorigenesis,
their
importance
prognostic
indicators
targets,
impact
on
tumor
microenvironment
(TME)
immune
response.
Ultimately,
this
highlights
interplay
between
copper,
immunotherapy.
Advanced Materials,
Год журнала:
2023,
Номер
36(8)
Опубликована: Окт. 11, 2023
Abstract
Activating
the
strong
immune
system
is
a
key
initiative
to
counteract
dormant
tumors
and
prevent
recurrence.
Herein,
self‐destructive
multienzymatically
active
copper‐quinone‐GOx
nanoparticles
(abbreviated
as
CQG
NPs)
have
been
designed
induce
harmonious
balanced
pyroptosis
cuproptosis
using
“Tai
Chi
mindset”
awaken
response
for
suppressing
recurrent
tumors.
This
cleverly
material
can
disrupt
antioxidant
defense
mechanism
of
tumor
cells
by
inhibiting
nuclear
factor‐erythroid
2‐related
factor
2
(NRF2)‐quinone
oxidoreductase
1
(NQO1)
signaling
pathway.
Furthermore,
combined
with
its
excellent
multienzyme
activity,
it
activates
NOD‐like
receptor
protein
3
(NLRP3)‐mediated
pyroptosis.
Meanwhile,
be
triggered
copper
ions
released
from
disintegration
NPs
sensitivity
cancer
enhanced
through
depletion
endogenous
chelators
via
Michael
addition
reaction
between
glutathione
(GSH)
quinone
ligand,
oxygen
production
catalase‐like
reaction,
starvation‐induced
glucose
deficiency.
More
importantly,
NPs‐induced
promote
immunosuppressive
microenvironment
(TME)
remodeling,
enhance
infiltration
into
tumor,
activate
robust
systemic
immunity.
Collectively,
this
study
provides
new
strategy
resist
dormancy,
recurrence,
improve
clinical
prognosis
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Авг. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Июнь 25, 2024
Abstract
Cuproptosis,
a
newly
identified
copper
(Cu)-dependent
form
of
cell
death,
stands
out
due
to
its
distinct
mechanism
that
sets
it
apart
from
other
known
death
pathways.
The
molecular
underpinnings
cuproptosis
involve
the
binding
Cu
lipoylated
enzymes
in
tricarboxylic
acid
cycle.
This
interaction
triggers
enzyme
aggregation
and
proteotoxic
stress,
culminating
death.
specific
has
yet
be
fully
elucidated.
recognized
sparked
numerous
investigations
into
role
tumorigenesis
cancer
therapy.
In
this
review,
we
summarized
current
knowledge
on
metabolism
link
cancer.
Furthermore,
delineated
mechanisms
roles
cuproptosis-related
genes
Finally,
offered
comprehensive
discussion
most
recent
advancements
ionophores
nanoparticle
delivery
systems
utilize
as
cutting-edge
strategy
for
treatment.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Materials,
Год журнала:
2024,
Номер
17(6), С. 1423 - 1423
Опубликована: Март 20, 2024
MXenes
are
two-dimensional
transition
metal
carbides,
nitrides,
and
carbonitrides
that
have
become
important
materials
in
nanotechnology
because
of
their
remarkable
mechanical,
electrical,
thermal
characteristics.
This
review
emphasizes
how
crucial
MXene
conjugates
for
several
biomedical
applications,
especially
the
field
cancer.
These
(2D)
nanoconjugates
with
photothermal,
chemotherapeutic,
photodynamic
activities
demonstrated
promise
highly
effective
noninvasive
anticancer
therapy.
conjugates,
distinctive
optical
capabilities,
been
employed
bioimaging
biosensing,
excellent
light-to-heat
conversion
efficiency
makes
them
perfect
biocompatible
notably
proficient
nanoscale
agents
photothermal
applications.
The
synthesis
characterization
provide
a
framework
an
in-depth
understanding
various
fabrication
techniques
importance
customized
formation
conjugates.
following
sections
explore
MXene-based
nanotheranostics
demonstrate
enormous
potential
Nanoconjugates,
such
as
polymers,
metals,
graphene,
hydrogels,
biomimetics,
quantum
dots,
radio
exhibit
unique
properties
can
be
used
therapeutic
diagnostic
applications
cancer
nanotheranostics.
An
additional
layer
into
safety
concerns
is
provided
by
detailing
toxicity
viewpoints.
Furthermore,
concludes
addressing
opportunities
challenges
clinical
translation
nanoconjugates,
emphasizing
real-world
medical
practices.
Nanoscale,
Год журнала:
2024,
Номер
16(18), С. 8708 - 8738
Опубликована: Янв. 1, 2024
Cancer
immunotherapy,
a
burgeoning
modality
for
cancer
treatment,
operates
by
activating
the
autoimmune
system
to
impede
growth
of
malignant
cells.
Although
numerous
immunotherapy
strategies
have
been
employed
in
clinical
therapy,
resistance
cells
immunotherapeutic
medications
and
other
apprehensions
attainment
sustained
advantages
most
patients.
Recent
advancements
nanotechnology
drug
delivery
hold
promise
augmenting
efficacy
immunotherapy.
However,
is
currently
constrained
inadequate
specificity
delivery,
low
rate
response,
intricate
immunosuppressive
tumor
microenvironment.
In
this
context,
investigation
cell
membrane
coated
nanoparticles
(CMNPs)
has
revealed
their
ability
perform
targeted
immune
evasion,
controlled
release,
immunomodulation.
By
combining
advantageous
features
natural
membranes
nanoparticles,
CMNPs
demonstrated
unique
potential
realm
This
review
aims
emphasize
recent
research
progress
elucidate
underlying
mechanisms
as
an
innovative
platform
enhancing
Additionally,
it
provides
comprehensive
overview
current
involving
different
types
CMNPs,
with
intention
further
exploration
optimization.
