European Polymer Journal, Год журнала: 2024, Номер unknown, С. 113683 - 113683
Опубликована: Дек. 1, 2024
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116783 - 116783
Опубликована: Май 25, 2024
During tumor development, the itself must continuously generate new blood vessels to meet their growth needs while also allowing for invasion and metastasis. One of most common features tumors is hypoxia, which drives process angiogenesis by regulating microenvironment, thus adversely affecting prognosis patients. In addition, overcome unsuitable environments growth, such as nutrient deficiency, hyperacidity, immunosuppression, microenvironment (TME) coordinates in several ways restore supply oxygen nutrients remove metabolic wastes. A growing body research suggests that hypoxia interact through a complex interplay crosstalk, inextricably linked TME. Here, we review TME's positive contribution from an angiogenesis-centric perspective considering objective impact hypoxic phenotypes status limitations current angiogenic therapies.
Язык: Английский
Процитировано
13
Cell Proliferation, Год журнала: 2024, Номер 57(6)
Опубликована: Янв. 16, 2024
Abstract Breast cancer has overtaken lung as the number one worldwide. Paclitaxel (PTX) is a widely used first‐line anti‐cancer drug, but it not very effective in clinical breast therapy. It been reported that triptolide (TPL) can enhance anticancer effect of paclitaxel, and better synergistic therapeutic effects are seen with concomitant administration PTX TPL. In this study, we developed pH‐responsive polymeric micelles for co‐delivery TPL, which disassembling acidic tumour microenvironments to target drug release effectively kill cells. Firstly, synthesized amphiphilic copolymer mPEG 2000 ‐PBAE through Michael addition reaction, confirmed by various characterizations. Polymer loaded TPL (TPL/PTX‐PMs) were prepared thin film dispersion method. The average particle size TPL/PTX‐PMs was 97.29 ± 1.63 nm, PDI 0.237 0.003 Zeta potential 9.57 0.80 mV, LC% 6.19 0.21%, EE% 88.67 3.06%. Carrier material biocompatibility micelle cytotoxicity assessed using CCK‐8 method, demonstrating excellent biocompatibility. Under same concentration, most toxic cells had strongest proliferation inhibitory effect. Cellular uptake assays revealed significantly increased intracellular concentration enhanced antitumor activity. Overall, micellar promising approach
Язык: Английский
Процитировано
10
Acta Biomaterialia, Год журнала: 2024, Номер 179, С. 13 - 35
Опубликована: Март 16, 2024
Язык: Английский
Процитировано
8
Cell Proliferation, Год журнала: 2024, Номер 57(8)
Опубликована: Апрель 26, 2024
Abstract Oral squamous cell carcinoma (OSCC), a type of malignant tumour that primarily occurs in the oral mucosa, has drawn considerable attention owing to its aggressive growth and potentially high metastatic rate. Surgical resection is primary treatment method for OSCC typically combined with radiation therapy chemotherapy. microRNA‐149‐3p (miR‐149) negative regulator Pi3k/Akt pathway can effectively inhibit proliferation cells. However, application miR‐149 limited relatively low efficiency cellular uptake poor stability when used alone. To overcome these challenges, this study adopted novel nucleic acid nanostructured material, tetrahedral framework acids (tFNAs). The use tFNAs as carriers assemble T‐miR‐149 complex reduced expression Pi3k Akt involved tumorigenesis alterations proteins related apoptosis. results indicated bionic drug delivery system an effective suppressive effect on mice, revealing potential clinical value OSCC.
Язык: Английский
Процитировано
5
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Фев. 11, 2024
Abstract Malignant tumours of the digestive system cover a wide range diseases that affect health people to large extent. Angiogenesis is indispensable in development, and metastasis tumours, mainly two ways: occupation or formation. Vessels can provide nutrients, oxygen, growth factors for encourage metastasis, so cancer progression depends on simultaneous angiogenesis. Recently, exosomes have been proven participate angiogenesis tumours. They influence by binding tyrosine kinase receptors (VEGFR)-1, VEGFR-2, VEGFR-3 with different affinities, regulating Yap-VEGF pathway, Akt pathway other signaling pathway. Additionally, are potential therapeutic vectors deliver many types cargoes cells. In this review, we summarize roles highlight clinical application prospects, directly used as targers delivery vehicles, antiangiogenic therapy.
Язык: Английский
Процитировано
4
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Авг. 26, 2024
To date, despite extensive research, the prognosis of advanced osteosarcoma has not improved significantly. Thus, patients experience a reduced survival rate, suggesting that reevaluation current treatment strategies is required. Recently, in addition to routine surgery, chemotherapy and radiotherapy, researchers have explored more effective safer treatments, including targeted therapy, immunotherapy, anti-angiogenesis metabolic targets nanomedicine therapy. The tumorigenesis development closely related angiogenesis. therapy crucial treat osteosarcoma; however, recent clinical trials found it insufficient efficacy. solve this problem, causes failure improve should be investigated. This review focuses on summarizing pathophysiological mechanisms angiogenesis advances osteosarcoma. We also discuss some studies, with aim providing new ideas for patients.
Язык: Английский
Процитировано
4
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158081 - 158081
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
3
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
A microneedle patch (B/S-TM@MN) was developed to encapsulate ROS-responsive micelles loaded with berberine and sinomenine, which enhanced the overall anti-arthritis outcome through simultaneous anti-inflammation anti-angiogenesis.
Язык: Английский
Процитировано
0
Clinical and Translational Medicine, Год журнала: 2025, Номер 15(4)
Опубликована: Апрель 1, 2025
Abstract Angiogenesis, as a core marker of cancer survival and growth, is integral to the processes tumour invasion metastasis. In recent years, targeted angiogenesis treatment strategies have gradually become an important direction in treatment. Single‐cell sequencing technology can provide new insights into by providing deeper understanding heterogeneity endothelial cells exploring interactions between surrounding microenvironment. Here, we systematically review research progress cell pathophysiology its endothelial‒mesenchymal transition illustrate from single‐cell perspective. Finally, examine contributions different types within microenvironment relation angiogenesis, well latest therapy, hoping useful clinical application antiangiogenic Furthermore, summary present development potential inhibitors ongoing trials for combination therapies provided. Key points Angiogenesis plays key role progression, metastasis, so targeting are becoming therapy. Interactions stromal immune significant angiogenesis. The immunotherapy nanotechnology therapy provides vital strategy prolonging patients.
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер 322, С. 123404 - 123404
Опубликована: Май 14, 2025
Язык: Английский
Процитировано
0