Optimizing interventional therapy: A homogeneous lipiodol formulation of Tirapazamine and Sorafenib responsive to post-embolization microenvironment

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 879 - 889

Опубликована: Янв. 30, 2025

Язык: Английский

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Recent advances on chitosan/hyaluronic acid-based stimuli-responsive hydrogels and composites for cancer treatment: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135893 - 135893

Опубликована: Сен. 1, 2024

Язык: Английский

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Stem cell therapies in the clinic

Bioengineering & Translational Medicine, Год журнала: 2025, Номер 10(3)

Опубликована: Фев. 4, 2025

Stem cell therapies have emerged as a transformative approach in modern medicine, with the potential to address and possibly cure broad spectrum of diseases. These utilize living stem cells that can perform complex biological functions not replicable by traditional drugs. an expanding therapeutic landscape, several products already approved numerous clinical trials underway. Among various types, hematopoietic (HSCs) mesenchymal (MSCs) are most widely studied. In this review, we provide detailed analysis current landscape therapies. We review 27 received regulatory approvals discuss 800 ongoing trials, focus on HSCs MSCs. also critical challenges be addressed facilitate translation

Язык: Английский

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Nanostructured Formulations for a Local Treatment of Cancer: A Mini Review About Challenges and Possibilities

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 205 - 205

Опубликована: Фев. 6, 2025

Cancer represents a significant societal, public health, and economic challenge. Conventional chemotherapy is based on systemic administration; however, it has current limitations, including poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, the development of multiple drug resistance. These factors underscore need for innovative strategies to enhance delivery directly tumours. However, local treatment also presents challenges, penetration through endothelial layers, tissue density in tumour microenvironment, interstitial fluid pressure, physiological conditions within tumour, permanence at site action. Nanotechnology promising alternative addressing these challenges. This narrative review elucidates potential nanostructured formulations cancer treatment, providing illustrative examples an analysis advantages challenges associated with this approach. Among nanoformulations developed breast, bladder, colorectal, oral, melanoma cancer, polymeric nanoparticles, liposomes, lipid nanohydrogels have demonstrated particular efficacy. systems permit mucoadhesion enhanced penetration, thereby increasing concentration (bioavailability) consequently improving anti-tumour efficacy potentially reducing effects. In addition studies indicating chemotherapy, nanocarriers can be used as theranostic approach combination irradiation methods.

Язык: Английский

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Repurposing chemotherapeutics in a hyaluronic acid-conjugate combination treatment approach for the local immunomodulation of the glioblastoma microenvironment

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125612 - 125612

Опубликована: Апрель 1, 2025

The immunosuppressive tumor immune microenvironment (TIME) renders glioblastoma (GBM) refractory to current chemo-immunotherapeutics. We sought explore a novel approach for local GBM-associated TIME immunomodulation based on synergistic combination of the repurposed chemotherapeutic drugs doxorubicin (DOX), which acts induce immunogenic cell death (ICD) and gemcitabine (GEM), depletes myeloid-derived suppressor cells (MDSCs). conjugated DOX GEM hyaluronic acid (HA) improve efficacy, given this polymer's ability target CD44 are overexpressed cancer cells. HA-DOX HA-GEM polymer-drug conjugates provided cytotoxic effects maintained ICD-related properties in GBM compared free drugs. also reverted orthotopic GL261 tumor-bearing mice by selectively depleting MDSCs reprogramming M2-like macrophages towards pro-inflammatory M1-like state, resulting controlled growth. Local delivery increased median survival growth an SB28-GBM mouse model. These findings highlight potential repurposing clinically applicable chemotherapeutics context treatments strategies unresectable GBM, may open new avenues developing innovative therapies.

Язык: Английский

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Graphene Quantum Dots from Natural Carbon Sources for Drug and Gene Delivery in Cancer Treatment

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10539 - 10539

Опубликована: Сен. 30, 2024

Cancer therapy is constantly evolving, with a growing emphasis on targeted and efficient treatment options. In this context, graphene quantum dots (GQDs) have emerged as promising agents for precise drug gene delivery due to their unique attributes, such high surface area, photoluminescence, up-conversion biocompatibility. GQDs can damage cancer cells exhibit intrinsic photothermal conversion singlet oxygen generation efficiency under specific light irradiation, enhancing effectiveness. They serve direct therapeutic versatile platforms capable of being easily functionalized various targeting molecules agents. However, challenges achieving uniform size morphology, bandgap engineering, scalability, along minimizing cytotoxicity the environmental impact production, must be addressed. Additionally, there need more comprehensive understanding cellular mechanisms release processes, well improved purification methods. Integrating into existing systems enhances efficacy traditional treatments, offering less invasive options patients. This review highlights transformative potential in while acknowledging that researchers overcome broader application.

Язык: Английский

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Research progress of sorafenib drug delivery system in the treatment of hepatocellular carcinoma: An update

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117118 - 117118

Опубликована: Июль 14, 2024

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors in contemporary era, representing a significant global health concern. Early HCC patients have mild symptoms or are asymptomatic, which promotes onset and progression disease. Moreover, advanced insensitive to chemotherapy, making traditional clinical treatment unable block cancer development. Sorafenib (SFB) first-line targeted drug for with anti-angiogenesis anti-tumor cell proliferation effects. However, efficacy SFB constrained by its off-target distribution, rapid metabolism, multi-drug resistance. In recent years, nanoparticles based on variety materials been demonstrated enhance targeting therapeutic against HCC. Concurrently, advent joint delivery systems has furnished crucial empirical evidence reversing This review will summarize application nanotechnology field over past five years. It focus research progress combined multiple modalities treatment.

Язык: Английский

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Prostate cancer chemotherapy by intratumoral administration of Docetaxel-Mesoporous silica nanomedicines

International Journal of Pharmaceutics, Год журнала: 2024, Номер 664, С. 124623 - 124623

Опубликована: Авг. 25, 2024

Docetaxel (DTX) is a recommended treatment in patients with metastasic prostate cancer (PCa), despite its therapeutic efficacy limited by strong systemic toxicity. However, localized PCa, intratumoral (IT) administration of DTX could be an alternative to consider that may help overcome the disadvantages conventional intravenous (IV) therapy. In this context, we here present first vivo preclinical study PCa therapy nanomedicines mesoporous silica nanoparticles (MSN) and IT injection over xenograft mouse model bearing human adenocarcinoma tumors. The tolerability, biodistribution histopathology after have been investigated for nanomedicine free drug, compared IV DTX. obtained results demonstrate allows precise selective non-metastatic minimize diffusion showing superior activity than route. This reducing dose one order widens substantially window drug. Furthermore, use as promotes antitumor drug accumulation at tumor site, improving same

Язык: Английский

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Nano‐ and Micro‐Platforms in Therapeutic Proteins Delivery for Cancer Therapy: Materials and Strategies

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Abstract Proteins have emerged as promising therapeutics in oncology due to their great specificity. Many treatment strategies are developed based on protein biologics, such immunotherapy, starvation therapy, and pro‐apoptosis while some biologics entered the clinics. However, clinical translation is severely impeded by instability, short circulation time, poor transmembrane transportation, immunogenicity. Micro‐ nano‐particles‐based drug delivery platforms designed solve those problems enhance therapeutic efficacy. This review first summarizes different types of proteins research stages, highlighting administration limitations. Next, various micro‐ nano‐particles described demonstrate how they can overcome The potential then explored efficacy combinational therapies. Finally, challenges future directions carriers discussed for optimized delivery.

Язык: Английский

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Enhancing localized chemotherapy with anti-angiogenesis and nanomedicine synergy for improved tumor penetration in well-vascularized tumors

npj Systems Biology and Applications, Год журнала: 2024, Номер 10(1)

Опубликована: Ноя. 20, 2024

Intratumoral delivery and localized chemotherapy have demonstrated promise in tumor treatment; however, the rapid drainage of therapeutic agents from well-vascularized tumors limits their ability to achieve maximum efficacy. Therefore, innovative approaches are needed enhance treatment efficacy such tumors. This study utilizes a mathematical modeling platform assess combination therapy using anti-angiogenic drugs drug-loaded nanoparticles. Anti-angiogenic included reduce blood microvascular density facilitate drug retention extracellular space. In addition, incorporating negatively charged nanoparticles aims diffusion distribution within The findings indicate that, case direct injection free drugs, compounds with lower rates higher coefficients is beneficial for achieving broader diffusion. Otherwise, tend accumulate primarily around site. For instance, doxorubicin, known its drainage, requires prior an high rate distribution, enhancing penetration depth by 200%. Moreover, results demonstrate that effectively disperse throughout tissue due coefficient. faster release further efficacy, necessary concentration complete eradication compared slower rates. demonstrates potential utilizing loaded exhibiting through intratumoral

Язык: Английский

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