International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 668, P. 124960 - 124960
Published: Nov. 16, 2024
Language: Английский
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5523 - 5544
Published: June 1, 2024
Metal-organic frameworks (MOFs) are porous materials resulting from the coordination of metal clusters or ions with organic ligands, merging macromolecular and chemistry features. Among these, zeolitic imidazolate framework-8 (ZIF-8) stands out as a widely utilized MOF known for its robust stability in aqueous environments owing to interaction between constituent zinc (Zn
Language: Английский
Citations
20
MedComm, Journal Year: 2025, Volume and Issue: 6(2)
Published: Jan. 21, 2025
Abstract Neutrophils, the most abundant circulating leukocytes, have long been recognized as key players in innate immunity and inflammation. However, recent discoveries unveil their remarkable heterogeneity plasticity, challenging traditional view of neutrophils a homogeneous population with limited functional repertoire. Advances single‐cell technologies assays revealed distinct neutrophil subsets diverse phenotypes functions ability to adapt microenvironmental cues. This review provides comprehensive overview multidimensional landscape heterogeneity, discussing various axes along which diversity manifests, including maturation state, density, surface marker expression, polarization. We highlight molecular mechanisms underpinning focusing on complex interplay signaling pathways, transcriptional regulators, epigenetic modifications that shape responses. Furthermore, we explore implications plasticity physiological processes pathological conditions, host defense, inflammation, tissue repair, cancer. By integrating insights from cutting‐edge research, this aims provide framework for understanding multifaceted roles potential therapeutic targets wide range diseases.
Language: Английский
Citations
3
Small, Journal Year: 2024, Volume and Issue: 20(43)
Published: July 14, 2024
This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.
Language: Английский
Citations
15
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101528 - 101528
Published: Jan. 30, 2025
Acute kidney injury (AKI) resulting from ischemia-reperfusion (IRI) is a common challenge in various clinical practices, yet effective therapies remain elusive. Endothelial plays crucial role the pathogenesis of renal IRI. progenitor cells (EPCs) derived extracellular vesicles (EVs) hold promise as cell-free for treating IRI; however, their efficacy limited by low delivery efficiency. In this study, we developed neutrophils (NEs) membrane-modified EVs (N-EVs) exploiting natural properties NEs to target damaged endothelium. N-EVs inherited characteristic membrane proteins along with biological functions EPCs-EVs. Results vitro and vivo experiments demonstrated that significantly enhanced targeting efficiency towards IRI kidneys via P-selectin glycoprotein ligand-1 (PSGL-1). Moreover, effectively promoted proliferation, migration, tube-formation abilities injured endothelial (ECs) contributed overall function improvement through targeted miR-21-5p. Additionally, could restore integrity, reduce cytokine release, inhibit leukocyte infiltration, hence alleviating inflammation. conclusion, our accessible engineering approach represents promising strategy Furthermore, hybrid modification can be tailored optimized broader applications other diseases.
Language: Английский
Citations
1
Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Abstract Macrophage polarization and energy metabolic reprogramming play pivotal roles in the onset progression of inflammatory arthritis. Moreover, although previous studies have reported that proviral integration Moloney virus 2 (Pim2) kinase is involved various cancers through mediation aerobic glycolysis cancer cells, its role arthritis remains unclear. In this study, we demonstrated multiple enzymes are activated upon Pim2 upregulation during M1 macrophage polarization. Specifically, directly phosphorylates PGK1-S203, PDHA1-S300, PFKFB2-S466, thereby promoting glycolytic reprogramming. expression was elevated macrophages from patients with collagen-induced (CIA) model mice. Conditional knockout or administration inhibitor HJ-PI01 attenuated development by inhibiting Through molecular docking dynamic simulation, bexarotene identified as an inhibits downstream polarization, mitigating For targeted treatment, neutrophil membrane-coated (Bex)-loaded PLGA-based nanoparticles (NM@NP-Bex) were developed to slow suppressing macrophages, these (NPs) exhibited superior therapeutic effects fewer side effects. Taken together, results our study targeting inhibition could effectively alleviate via reversal M1/M2 imbalance. NM@NPs loaded represent a promising strategy for treatment
Language: Английский
Citations
1
Matter, Journal Year: 2024, Volume and Issue: 7(11), P. 3811 - 3844
Published: Nov. 1, 2024
Language: Английский
Citations
4
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 404 - 416
Published: Feb. 10, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113648 - 113648
Published: March 1, 2025
Language: Английский
Citations
0
Science Advances, Journal Year: 2025, Volume and Issue: 11(12)
Published: March 19, 2025
Acute organ injuries represent a major public health concern, driven by inflammation and mitochondrial dysfunction, leading to cell damage failure. In this study, we engineered neutrophil membrane–fused mitochondria (nMITO), which combine the injury-targeting anti-inflammatory properties of membrane proteins with repairing function mitochondria. nMITO effectively blocked inflammatory cascades restored function, targeting both key mechanisms in acute injuries. addition, selectively targeted damaged endothelial cells via β-integrins were delivered injured tissues through tunneling nanotubes, enhancing their regulatory effects on damage. mouse models myocardial injury, liver pancreatitis, notably reduced responses repaired tissue These findings suggest that is promising therapeutic strategy for managing
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113752 - 113752
Published: April 1, 2025
Language: Английский
Citations
0