Ethosome-Based Transdermal Drug Delivery: Its Structural Components, Preparation Techniques, and Therapeutic Applications Across Metabolic, Chronic, and Oncological Conditions
Pharmaceutics,
Год журнала:
2025,
Номер
17(5), С. 583 - 583
Опубликована: Апрель 29, 2025
Transdermal
drug
delivery
systems
(TDDSs)
provide
a
non-invasive
alternative
to
oral
and
parenteral
routes,
delivering
drugs
into
the
bloodstream
while
avoiding
gastrointestinal
degradation
first-pass
metabolism.
Despite
benefits
like
enhanced
bioavailability
patient
compliance,
stratum
corneum
limits
permeation.
Ethosomes
overcome
barrier
with
superior
flexibility
permeability
compared
liposomes.
Ethanol
disrupts
skin’s
lipid
bilayer,
enabling
deep
penetration
efficient
delivery.
offer
high
entrapment
efficiency
stability,
both
hydrophilic
lipophilic
drugs.
However,
challenges
stability
optimization
clinical
translation
persist.
This
review
examines
structural
components,
preparation
methods,
therapeutic
applications
of
ethosomes
in
metabolic
chronic
diseases,
including
diabetes,
cardiovascular
neurodegenerative
disorders,
arthritis,
cancers.
Moreover,
it
highlights
potential
revolutionize
TDDSs
for
managing
providing
foundation
further
research
development.
Язык: Английский
A Comprehensive Review on Current Knowledge and Future Potential of Topical Therapies in Breast Cancer Treatment
Meme sağlığı dergisi/Meme sağlığı dergisi,
Год журнала:
2025,
Номер
21(1), С. 9 - 15
Опубликована: Янв. 2, 2025
Key
Points
•Topical
therapies
are
localized
treatments
that
target
the
breast
tumour
location
specifically.•
By
limiting
drug's
exposure
to
rest
of
body,
this
strategy
lowers
possibility
systemic
adverse
effects.
•The
efficacy
therapy
may
be
increased
by
direct
application
location.•
These
function
directly
targeting
cancer
cells
through
skin
penetration,
which
can
help
minimise
size
and
relieve
symptoms.•
To
increase
overall
effectiveness
treatment,
topical
frequently
used
in
conjunction
with
other
including
radiation,
surgery,
or
chemotherapy.
Язык: Английский
Dissolving PEGDA-Based Microneedles to Transdermally Deliver PDA@Cu with Photothermal Properties for Potential Antibacterial Applications
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(51), С. 70339 - 70351
Опубликована: Дек. 13, 2024
The
stratum
corneum
of
the
skin
functions
as
a
barrier,
obstructing
drug
absorption
and
complicating
treatment
infections
caused
by
pathogens
such
bacteria,
fungi,
viruses
through
topical
methods.
In
this
research,
microneedle
patch
was
developed,
which
consists
gelatin-sucrose
(SG)
that
encapsulates
polydopamine-copper
nanoparticles
(PDA@Cu)
at
tip
for
antibacterial
purposes.
Poly(ethylene
glycol)
diacrylate
(PEGDA)
served
primary
substrate
shaft
(PDA@Cu-SG/PEGDA).
This
engineered
to
enhance
permeability
facilitate
efficient
delivery
drugs
rapid
dissolution
tips.
Coordinate
bonds
can
be
formed
between
PDA
Cu
ions,
resulting
in
immobilization
particles
on
surface,
aids
green
synthesis
PDA@Cu
photothermal
particles.
SG
polymer,
contained
PDA@Cu,
employed
fill
cavities
series
centrifugation
steps.
Subsequently,
UV-induced
polymerization
carried
out
produce
PEGDA
microneedles
with
hydrophilic
tips
Furthermore,
physicochemical
characteristics
polymer
microneedles,
including
morphology,
composition,
mechanical
strength,
were
thoroughly
characterized.
These
demonstrated
sufficient
strength.
Owing
ability
disrupt
bacterial
membranes,
excellent
vitro
efficacy.
We
validated
activity
against
Escherichia
coli
Staphylococcus
aureus
conducting
plate
coating
assays.
results
assays
indicated
minimally
invasive
strategy
achieved
broad-spectrum
effects;
thus,
may
suitable
approach
managing
polymicrobial
during
clinical
trials.
Язык: Английский
Dissolving Microneedles as In Situ Chemical Reaction Chambers: from Design Strategies to Versatile Biomedical Applications
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Abstract
The
skin
microenvironment
is
a
highly
intricate
and
dynamic
system,
characterized
by
an
acidic
pH,
diverse
microbiota,
various
metabolites,
numerous
enzymes,
creating
both
challenges
opportunities
for
the
development
of
innovative
drug
delivery
systems.
Dissolving
Microneedles
(MNs)
have
emerged
as
promising,
pain‐free
alternative
to
conventional
invasive
injections,
offering
ability
deliver
therapeutics
through
gradual
degradation
within
skin's
interstitial
fluids.
Building
upon
unique
properties
dissolving
MNs,
novel
concept
introduced
wherein
MNs
serve
in
situ
chemical
reaction
chambers.
In
this
framework,
can
reactants
or
catalysts
skin,
enabling
initiation
specific
reactions,
such
prodrug
activation
targeted
therapy,
harmful
enhanced
synthesis
beneficial
molecules.
Moreover,
review
systematically
explores
potential
chambers,
discussing
key
aspects
their
sustained
release
mechanisms,
design
strategies,
range
therapeutic
applications.
Finally,
forward‐looking
perspective
provided
on
future
addressing
broader
clinical
translation
application
personalized
medicine.
Язык: Английский
Bimodal Dissolving Microneedles with Nanoparticle Coating and Encapsulation for Extended Dual‐Drug Delivery
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 26, 2025
Abstract
Effective
co‐delivery
of
multiple
drugs
via
microneedle
(MN)
platforms
is
challenging
due
to
limited
loading
capacity
and
the
need
for
sustained
release.
This
study
presents
a
bimodal
coated‐dissolving
(DMN)
patch
extended
delivery
diclofenac
(DCF)
dexamethasone
(DSP)
nanoparticles
treat
osteoarthritis.
The
DMN
tips
are
loaded
with
DCF
(3.84
mg/patch)
coated
DSP‐PLGA
nanosuspensions
(0.44
mg/patch),
achieving
dual‐drug
release
from
single
patch.
Ex
vivo
studies
in
neonatal
porcine
skin
show
>
90%
penetration
into
stratum
corneum
(≈276
µm
depth),
transdermal
1.54
mg
118
µg
DSP
at
24
h.
In
pharmacokinetic
rats
demonstrate
plasma
levels
72
h,
an
half‐life
(13.0
h)
80.3%
relative
bioavailability
compared
oral
dosing.
exhibits
biphasic
release,
peaking
24–30
h
(227.7
ng
mL
−1
,
63.9%
bioavailability).
High
drug
persist
paw
tissues
suggesting
prolonged
local
efficacy.
These
DMNs
provide
high‐loading,
sustained‐release
platform
minimally
invasive,
patient‐friendly
therapy,
optimizing
osteoarthritis
treatment
improving
compliance.
Язык: Английский
Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Phytochemicals,
which
are
predominantly
found
in
plants,
hold
substantial
medicinal
value.
Despite
their
potential,
challenges
such
as
poor
oral
bioavailability
and
instability
the
gastrointestinal
tract
have
limited
therapeutic
use.
Traditional
intra/transdermal
drug
delivery
systems
offer
some
advantages
over
administration
but
still
suffer
from
issues
penetration
depth,
slow
release
rates,
inconsistent
absorption.
In
contrast,
microneedles
(MNs)
represent
a
significant
advancement
by
providing
precise
control
phytochemical
enhanced
capabilities.
By
circumventing
skin
barriers,
MNs
directly
access
dermal
layers
rich
blood
vessels
lymphatics,
thus
facilitating
efficient
delivery.
This
review
extensively
discusses
obstacles
of
traditional
benefits
routes
with
particular
focus
on
transformative
potential
for
explores
complexities
delivering
phytochemicals
through
routes,
development
types
innovative
tools,
optimal
design
properties
effective
Additionally,
this
examines
versatile
applications
MN-mediated
delivery,
including
its
role
administering
phytophotosensitizers
photodynamic
therapy,
concludes
insights
into
relevant
patents
future
perspectives.
Язык: Английский
Recent Developments in Using Microneedle Patch Technology as a More Efficient Drug Delivery System for Treating Skin Photoaging
Clinical Cosmetic and Investigational Dermatology,
Год журнала:
2024,
Номер
Volume 17, С. 2417 - 2426
Опубликована: Окт. 1, 2024
Skin
photoaging,
resulting
from
prolonged
exposure
to
ultraviolet
(UV)
radiation,
is
characterized
by
intricate
biological
changes
involving
oxidative
damage
and
structural
alterations.
Despite
an
increasing
demand
for
effective
interventions,
the
current
therapeutic
options
treating
skin
photoaging
are
limited.
We
discovered
through
literature
data
search
on
PubMed
that
recent
research
has
shifted
its
focus
application
of
microneedle
patches
as
innovative
approach
address
this
concern.
Microneedle
patches,
serving
a
novel
transdermal
delivery
system,
exhibit
potential
deliver
bioactive
substances
such
cytokines,
cellular
vesicles,
gene
fragments
even
alive
algae
mitigate
effects
photoaging.
This
review
aims
provide
comprehensive
overview
advancements
in
about
utilizing
treatment
future
directions
leveraging
clinical
agents
rejuvenation.
Ultimately,
we
believe
have
broader
prospect
fields
medical
cosmetology
anti-photoaging.
Язык: Английский
Antiproliferative and Morphological Effects of Fenretinide Lipid Nanosystems in Colon Adenocarcinoma Cells
Lorenzo Anconelli,
Francesca Farioli,
Pietro Lodeserto
и другие.
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1421 - 1421
Опубликована: Ноя. 6, 2024
Colon
adenocarcinoma
is
characterized
by
the
downregulation
of
retinoic
acid
receptor,
making
natural
retinoids
such
as
all-trans
acid,
9-cis
and
13-cis
effective
in
treatment
chemoprevention
due
to
their
ability
increase
RARβ
expression.
However,
major
limitations
use
include
tolerability
acquired
resistance.
In
this
study,
we
evaluated
fenretinide,
a
semisynthetic
derivative
an
HT-29
cell
line.
Fenretinide
was
both
free
drug
encapsulated
self-assembling
phosphatidylcholine
nanosystems
with
aim
increasing
aqueous
solubility
availability
drug.
Язык: Английский
A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Nanomaterial‐loaded
microneedles
are
a
novel
development
in
the
fields
of
medicine
and
vaccines.
Researchers
have
created
extremely
effective
systems
for
targeted
controlled
delivery
variety
bioactive
agents
by
fusing
nanomaterials
with
microneedle
platforms.
The
design
manufacturing
processes
nanomaterial‐loaded
covered
herein,
along
applications
to
improve
drug
stability,
bioavailability,
patient
adherence.
Important
preclinical
clinical
studies
that
demonstrate
efficiency
these
delivering
small
molecules,
biologics,
vaccines
also
review.
In
order
direct
ongoing
research
expedite
translation
this
promising
technology,
important
challenges
future
directions
identified.
This
review
offers
thorough
evaluation
most
recent
developments
quickly
developing
field
technology.
Язык: Английский