Inhibition of ER stress using tauroursodeoxycholic acid rescues obesity-evoked cardiac remodeling and contractile anomalies through regulation of ferroptosis
Chemico-Biological Interactions,
Год журнала:
2024,
Номер
398, С. 111104 - 111104
Опубликована: Июнь 19, 2024
Язык: Английский
The Association Between the Triglyceride–Glucose Index, Its Combination with the Body Roundness Index, and Chronic Kidney Disease in Patients with Type 2 Diabetes in Eastern China: A Preliminary Study
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 492 - 492
Опубликована: Янв. 29, 2025
Objectives:
This
study
aimed
to
investigate
the
relationship
between
triglyceride–glucose
(TyG)
index,
its
combination
with
body
roundness
index
(BRI),
and
chronic
kidney
disease
(CKD)
in
patients
type
2
diabetes
mellitus
(T2DM)
based
on
a
cross-sectional
analysis
conducted
Eastern
China.
Methods:
The
research
originates
from
performed
Zhejiang
Province,
China,
March
November
2018.
TyG-BRI
was
calculated
triglyceride,
fasting
blood
glucose,
BRI.
correlation
risk
of
CKD
assessed
using
restricted
cubic
spline
model.
A
multivariate
logistic
regression
model
used
association
CKD.
Receiver
operating
characteristic
(ROC)
analyses
evaluate
optimal
cut-off
value
for
predicting
Results:
total
1756
T2DM
participants
were
enrolled
this
study.
significantly
higher
than
those
without
In
fully
adjusted
model,
odds
ratios
second,
third,
fourth
quartiles
0.93
(95%
CI:
0.65–1.33),
1.33
0.94–1.88),
1.57
1.10–2.25),
respectively,
compared
first
quartile.
RCS
confirmed
linear
dose–response
(all
p
nonlinearity
>
0.05).
ROC
curve
revealed
that
had
moderate
predictive
CKD,
an
area
under
0.626
0.597–0.656,
<
0.001).
42.46,
sensitivity
68.2%
specificity
52.2%.
Conclusions:
positively
associated
population,
demonstrating
value.
It
may
serve
as
valuable
tool
identifying
high-risk
individuals
informing
targeted
interventions
prevent
or
delay
progression
population.
Язык: Английский
The Kidney in Obesity: Current Evidence, Perspectives and Controversies
Current Obesity Reports,
Год журнала:
2024,
Номер
13(4), С. 680 - 702
Опубликована: Авг. 14, 2024
Язык: Английский
The Perceptions of and Attitudes Toward Obesity in Bulgarian Adults with a BMI ≥ 25.0 kg/m2—An Exploratory Study
Mihail Boyanov,
Margarita Boeva Grigorova,
Anna Todorova Karteva-Stoycheva
и другие.
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 373 - 373
Опубликована: Янв. 21, 2025
Background:
Obesity
affects
33.2%
of
the
adult
population
in
Bulgaria,
and
there
is
a
scarcity
information
about
affected
individuals’
attitudes
toward
their
weight
situation.
The
aim
this
study
was
to
explore
perceptions
obesity
adults.
Methods:
present
involved
questionnaire-based
survey
that
utilized
home-based
tablet-assisted
face-to-face
interviews.
Interviewees
comprised
individuals
aged
25–64
y/o
with
BMI
>
25.0
kg/m2.
Results:
Overall,
704
respondents
participated
(344
overweight;
360
obese).
Over
50%
participants
reported
attempts
reduce
weight,
only
6%
overweight
group
16%
obese
perceiving
condition
as
worrisome.
One-third
considered
state
temporary.
main
cause
for
alarm
overweight/obese
worsening
overall
physical
males
an
increase
clothes
size
females.
need
urgent
reduction
body
noted
by
12%
40%
respondents.
reasons
being
were
collated
lack
activity
(noted
52%
participants),
sedentary
lifestyle
(51%),
stress/depression
(41%),
excessive
consumption
carbohydrates
(34%),
general
overconsumption
food
(33%),
poor
quality
products
(28%).
Of
note,
56%
had
first
consulted
medical
professional
overweight.
Most
selected
dieting
without
reduction,
48%
stating
they
would
try
drugs
approved
reduction.
Conclusions:
Many
have
unrealistic
self-perception
very
low
motivation
take
active
measures.
These
discrepancies
offer
great
opportunities
better
public
education
structured,
strategies.
Язык: Английский
Chronic kidney disease awareness: a cross-sectional study in primary care settings in Türkiye
Journal of Nephrology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Abstract
Background
Raising
awareness
of
chronic
kidney
disease
(CKD)
is
essential
for
early
detection
and
prevention,
since
the
condition
remains
largely
underdiagnosed,
particularly
in
primary
care
settings.
The
present
study
aimed
to
evaluate
levels
regarding
causes
symptoms
CKD
among
individuals
receiving
care.
Methods
This
cross-sectional
included
457
participants
recruited
from
two
centers
Türkiye
using
systematic
random
sampling.
data
were
collected
via
face-to-face
interviews
a
pre-tested
questionnaire
between
April
June
2023.
Awareness
classified
Bloom’s
cutoff
points–high
(≥
80%),
moderate
(60–79%),
low
(<
60%).
Results
mean
age
was
42.3
±
14.9
years.
population
consisted
55.4%
women,
51.2%
aged
18–39,
74.6%
married,
53.4%
held
at
least
university
bachelor’s
degree.
As
awareness,
64.1%
aware
that
can
be
caused
by
pain
medication,
56%
it
hypertension,
48.8%
result
diabetes.
Additionally,
58.6%
swelling
feet
ankles
represent
symptom
CKD.
78.6%
our
(n
=
359),
17.5%
(
n
80)
high
3.9%
18).
Individuals
who
recalled
having
been
informed
about
these
their
physicians
exhibited
higher
awareness.
No
significant
differences
observed
across
different
sociodemographic
groups.
A
positive
correlation
its
symptoms.
Conclusions
limited,
nearly
half
being
unaware
key
risk
factors
such
as
painkiller
use,
obesity,
smoking,
diabetes,
herbal
product
use.
Increased
education,
physicians,
may
improve
rates.
Graphical
abstract
Язык: Английский
Performance of Current Chronic Kidney Disease Screening Criteria in Women and Men Across Ethnic Groups: The HELIUS Study
Mayo Clinic Proceedings Innovations Quality & Outcomes,
Год журнала:
2025,
Номер
9(3), С. 100613 - 100613
Опубликована: Апрель 17, 2025
Язык: Английский
Multifrequency Low-level Laser-Assisted Lipolysis Outcomes. A Dataset from 101 patients
Data in Brief,
Год журнала:
2024,
Номер
57, С. 111038 - 111038
Опубликована: Окт. 18, 2024
Язык: Английский
Influence of melatonin on the development of obesity
Новые Санкт-Петербургские врачебные ведомости.,
Год журнала:
2024,
Номер
2, С. 25 - 33
Опубликована: Ноя. 1, 2024
In
recent
years,
increasing
attention
of
researchers
has
been
paid
to
the
role
melatonin
in
regulation
body
weight.
When
analyzing
literature
data,
problem
mechanism
action
on
and
its
use
correction
metabolic
disorders
is
considered.
Disruption
circadian
rhythms
caused
by
artificial
light
at
night
leads
decreased
secretion.
This
helps
increase
appetite
reduce
energy
costs.
addition,
plays
a
major
modulating
secretion
adipokines
influencing
lipid
metabolism.
Decreased
production
causes
insulin
resistance
disorganization,
leading
obesity.
Assessing
development
obesity
accompanying
pathologies
promising
area
scientific
research
field
diagnosis,
prevention
treatment
endocrine
cardiovascular
pathologies.
Язык: Английский