Archives of Pharmaceutical Sciences Ain Shams University,
Год журнала:
2023,
Номер
7(2), С. 482 - 501
Опубликована: Дек. 1, 2023
Neurodegenerative
diseases
(NDDs),
a
global
growing
concern,
are
posing
significant
social
and
economic
challenges,
making
the
efficient
delivery
of
medications
to
brain
pressing
demand.Over
past
decade,
several
strategies
have
been
developed
facilitate
targeting,
circumvent
formidable
obstacle
presented
by
blood-brain
barrier
(BBB).These
tactics
encompass
both
non-invasive
invasive
approaches,
with
utilization
nanocarriers
being
increasingly
prevalent
due
various
advantages
they
offer.Likewise,
intranasal
(IN)
drugs
is
considered
one
most
practical
techniques
that
can
bypass
BBB,
mitigating
systemic
adverse
effects
reducing
administered
doses,
in
addition
to,
added
pros
greater
bioavailability,
enhanced
cerebral
exposure
at
comparable
oral
doses.This
review
aims
elucidate
recent
approaches
employed
therapeutics
brain,
thorough
emphasis
on
IN
route
for
targeted
drug
delivery.
Molecular Neurobiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 17, 2024
Abstract
Demyelination
is
a
frequent
yet
crippling
neurological
disease
associated
with
multiple
sclerosis
(MS).
The
cuprizone
(CZ)
model,
which
causes
demyelination
through
oxidative
stress
and
neuroinflammation,
popular
tool
used
by
researchers
to
examine
this
process.
polyphenol
resveratrol
(RESV)
has
become
promising
neuroprotective
agent
in
seeking
for
efficient
therapies.
In
rat
model
given
CZ,
we
created
examined
iron
oxide
nanoparticles
(IONPs)
loaded
RESV
(IONP-RESV)
see
how
effective
they
were
as
therapeutic
against
free
RESV.
According
molecular
mechanisms,
exposure
CZ
resulted
marked
downregulation
of
myelin
proteolipid
protein
(PLP)
expression
an
overexpression
the
inflammatory
markers
tumor
necrosis
factor-α
(TNF-α)
S100β,
are
indicators
neuroinflammation.
It
remarkable
that
these
CZ-induced
alterations
could
be
reversed
therapy
either
or
IONP-RESV.
Interestingly,
IONP-RESV
showed
even
stronger
anti-inflammatory
activity,
shown
more
noticeable
TNF-α
S100β
expression.
These
results
confirmed
histopathological
examination
cerebral
cortices.
Our
findings
support
better
benefits
RESV-loaded
IONPs
over
reducing
neuroinflammation
brought
on
CZ.
Owing
their
pro-remyelinating,
anti-inflammatory,
antioxidant
properties,
show
promise
neurotherapeutic
intervention
future
diseases
such
sclerosis.
Graphical
Parkinson's
disease
(PD),
the
second
most
common
neurological
ailment
in
world
after
Alzheimer's
(AD),
affects
about
1%
of
those
over
65
years.
Exosomes
were
first
thought
to
be
useless
cell
debris.
It
has
been
discovered
that
exosomes
contain
a
variety
non-coding
RNAs,
including
microRNAs,
lncRNAs,
and
circRNAs,
as
well
other
bioactive
compounds.
A
few
these
compounds
are
functional
messenger
RNAs
(mRNAs),
certain
proteins,
lipids,
chemicals.
Our
understanding
exosome
function
body
improved
result
this
information.
physiological
activities
show
important
include
migration,
angiogenesis,
intercellular
communication,
anti-tumor
immunity.
can
help
nervous
system's
cells
communicate
with
one
another,
get
rid
waste,
keep
myelin
coating
place.
Similar
this,
it
is
possible
development
central
system
illnesses
like
influenced
by
brain
exosomes.
The
several
neurodegenerative
disorders
(NDD),
mostly
attributed
extracellular
vehicles
(EVs)
known
(EXOs).
As
result,
have
attracted
attention
EVs
pathophysiological
roles.
Because
their
shown
ability
transport
both
pathogenic
therapeutic
cargo,
researchers
altered
EXOs
for
use
drug
delivery.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9690 - 9690
Опубликована: Сен. 7, 2024
Alzheimer’s
disease
(AD)
still
prevails
and
continues
to
increase
indiscriminately
throughout
the
21st
century,
is
thus
responsible
for
depreciating
quality
of
health
associated
sectors.
AD
a
progressive
neurodegenerative
disorder
marked
by
significant
amassment
beta-amyloid
plaques
neurofibrillary
tangles
near
hippocampus,
leading
consequent
loss
cognitive
abilities.
Conventionally,
amyloid
tau
hypotheses
have
been
established
as
most
prominent
in
providing
detailed
insight
into
pathogenesis
revealing
associative
biomarkers
intricately
involved
progression.
Nanotheranostic
deliberates
rational
thought
toward
designing
efficacious
nanosystems
strategic
endeavors
diagnosis
therapeutic
implications.
The
exceeding
advancements
this
field
enable
scientific
community
envisage
conceptualize
pharmacokinetic
monitoring
drug,
sustained
targeted
drug
delivery
responses,
fabrication
anti-amyloid
therapeutics,
enhanced
accumulation
across
blood–brain
barrier
(BBB),
giving
an
optimistic
approach
towards
personalized
precision
medicine.
Current
methods
idealized
on
design
bioengineering
array
nanoparticulate
systems
offer
higher
affinity
neurocapillary
endothelial
cells
BBB.
They
recently
attracted
intriguing
attention
early
diagnostic
measures
taken
manage
progression
disease.
In
article,
we
tend
furnish
comprehensive
outlook,
mechanism
conventional
pathogenesis,
new
findings.
We
also
summarize
shortcomings
diagnostic,
prognostic,
approaches
undertaken
alleviate
AD,
unique
window
nanotheranostic
without
disregarding
potential
drawbacks,
side
effects,
safety
concerns.
Foods,
Год журнала:
2024,
Номер
13(14), С. 2289 - 2289
Опубликована: Июль 20, 2024
Neurodegenerative
disorders
(NDDs)
such
as
Alzheimer’s
(AD)
and
Parkinson’s
(PD)
are
on
the
rise,
robbing
people
of
their
memories
independence.
While
risk
factors
age
genetics
play
an
important
role,
exciting
studies
suggest
that
a
diet
rich
in
foods
from
plant
origin
may
offer
line
defense.
These
kinds
foods,
namely
fruits
vegetables,
packed
with
plethora
powerful
bioactive
secondary
metabolites
(SBMs),
including
terpenoids,
polyphenols,
glucosinolates,
phytosterols
capsaicinoids,
which
exhibit
wide
range
biological
activities
antioxidant,
antidiabetic,
antihypertensive,
anti-Alzheimer’s,
antiproliferative,
antimicrobial
properties,
associated
preventive
effects
development
chronic
diseases
mediated
by
oxidative
stress
type
2
diabetes
mellitus,
respiratory
diseases,
cancer,
cardiovascular
NDDs.
This
review
explores
potential
SBMs
theravention
agents
(metabolites
therapeutic
action)
against
By
understanding
science
behind
plant-based
prevention,
we
be
able
to
develop
new
strategies
promote
brain
health
prevent
rise
The
proposed
stands
out
emphasizing
integration
multiple
preventing
Previous
research
has
often
focused
individual
compounds
or
specific
but
this
aims
present
comprehensive
fingerprint
how
various
can
synergistically
contribute
health.
related
NDD
diagnostic
process,
addition
some
examples
food-related
products
medicinal
plants
significantly
reduce
inhibition
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE),
β-site
amyloid
precursor
protein
(APP)
cleaving
enzyme
1
(BACE1),
highlighted.
International Journal of Surgery,
Год журнала:
2024,
Номер
110(11), С. 6873 - 6882
Опубликована: Июль 23, 2024
Hepatic
encephalopathy
and
other
neurodegenerative
disorders
have
profound
implications
for
extensive
liver
impairment,
calling
new
ways
of
treating
the
condition.
The
application
stem
cell
transplantation
to
treat
these
severe
is
a
encouraging
technique.
This
review
article
digs
deep
into
subject
therapy,
associated
with
advanced
damage,
transplantation.
It
comprehensively
analyses
background,
rationale,
scope,
objectives
using
cells
such
challenging
conditions.
topic
discussion
includes
subtleties
disorders,
function
transplantation,
possible
advantages
disadvantages
it.
relevance
patient
selection,
intraoperative
concerns
post-transplant
care
discussed.
Further,
explores
how
cell-based
therapies
can
benefit
from
nanotechnology,
specifically
it
improve
distribution,
survival,
integration
better
therapeutic
results.
aims
offer
thorough
analysis
regenerative
medicine's
present
future
possibilities
in
dealing
intricate
relationship
between
neurodegeneration
damage.
does
this
by
examining
efficacy,
safety,
long-term
impacts
will
incorporate
insights
ongoing
clinical
trials,
patent
landscape,
directions.
goal
pave
way
innovative
personalized
treatment
approaches
evolving
research
practice
field.
Therefore,
efforts
represent
promising
frontier
medical
that
alleviate
burden
HE
neurological
complications
combined
cirrhosis.
IntechOpen eBooks,
Год журнала:
2023,
Номер
unknown
Опубликована: Март 15, 2023
Effective
treatment
of
brain
disorders
remains
a
tough
task
in
medical
science.
Age-old
like
Parkinson’s
(PD)
and
Alzheimer’s
(AD)
are
yet
to
be
managed
effectively
spite
fabulous
scientific
progress
over
the
last
decades.
Presently
available
strategies
have
been
found
insufficient
tackle
out
bursting
cases
AD
PD.
Indeed,
presence
blood-brain
barrier
(BBB)
highly
hijacks
success
conventional
drug
therapy.
In
this
regard,
phyto
bioactive
components
delivered
through
nanocarrier
(NCs)
systems
hold
ray
hope
improving
benefits
disorders.
Several
NCs
including
polymeric
nanoparticles,
nanoliposomes,
micelles,
dendrimers
now
being
heavily
researched
deliver
active
tissue.
owing
their
structural
physiological
uniqueness
evolved
with
great
potential
for
Functionalization
specific
ligands
on
surface
further
makes
them
target
specific,
which
might
significantly
improve
bioavailability
or
reduce
off-target
adverse
effects.
This
chapter
primarily
focuses
recent
advancements
component
loaded
employed
The
especially
covers
existing
impediments
based
Parkinson
disease.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 189 - 240
Опубликована: Апрель 5, 2024
Pomegranate
(Punica
granatum)
seeds
are
famous
for
their
rich
phytochemical
composition,
especially
antioxidant
polyphenols.
The
therapeutic
potential
of
pomegranate
and
bioactive
ingredients
is
discovered
in
this
abstract.
main
components
like
polyphenols,
ellagic
acid,
anthocyanins,
exhibit
qualities.
These
crucial
neutralizing
dangerous
free
radicals,
which
reduces
inflammation
oxidative
stress.
have
a
variety
advantages.
include
benefits
that
neuroprotective,
cardioprotective,
anti-diabetic,
anti-inflammatory,
anti-cancer.
also
antimicrobial
qualities,
improve
immunological
function,
regulate
lipid
metabolism.
Promising
indications
been
presented
by
experimental
research
trials
to
support
the
health-promoting
properties
seeds.
studies
suggest
possible
uses
treatment
prevention
diseases
diabetes,
cancer,
heart
disease,
metabolic
disorders,
neurological
disorders.
