Chitosan scaffolds: Expanding horizons in biomedical applications

Carbohydrate Polymers, Год журнала: 2023, Номер 323, С. 121394 - 121394

Опубликована: Сен. 16, 2023

Язык: Английский

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Nano-hydroxyapatite (nHAp) scaffolds for bone regeneration: Preparation, characterization and biological applications

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105601 - 105601

Опубликована: Март 18, 2024

Язык: Английский

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Exploring modified chitosan-based gene delivery technologies for therapeutic advancements

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129581 - 129581

Опубликована: Янв. 22, 2024

Язык: Английский

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Multifunctional hydrogels-based therapies for chronic diabetic wound healing

European Polymer Journal, Год журнала: 2024, Номер 211, С. 113026 - 113026

Опубликована: Апрель 8, 2024

Chronic diabetic wounds persist as a healthcare challenge and therefore require the use of innovative therapeutic approaches. Among emerging solutions, hydrogels stand out promising avenue for wound healing due to their unique properties versatile applications, capable addressing complex challenging microenvironment that characterizes such wounds. In this work, through detailed analysis relevant experimental studies, we highlight multifunctionality hydrogels, namely ability promote tissue attachment, prevent scarring, fight infection, attenuate inflammation, facilitate electrical signaling, control bleeding, repair damage autonomously, exhibit responses tailored specific characteristics. The collective findings from these studies emphasize attributes in challenges. By elucidating crucial insights, work seeks lay groundwork both academics industries development implementation effective hydrogel-based strategies can significantly improve outcomes, offering new hope patients suffering chronic

Язык: Английский

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Nanoparticle-Based Approaches for Treatment of Hematological Malignancies: a Comprehensive Review

AAPS PharmSciTech, Год журнала: 2023, Номер 24(8)

Опубликована: Ноя. 16, 2023

Язык: Английский

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Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(44), С. 10538 - 10565

Опубликована: Янв. 1, 2023

Polysaccharides have found extensive utilization as biomaterials in drug delivery systems owing to their remarkable biocompatibility, simple functionalization, and inherent biological properties.

Язык: Английский

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Nanogels in Biomedical Engineering: Revolutionizing Drug Delivery, Tissue Engineering, and Bioimaging

Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(10)

Опубликована: Окт. 1, 2024

ABSTRACT Nanogels represent a significant innovation in the fields of nanotechnology and biomedical engineering, combining properties hydrogels nanoparticles to create versatile platforms for drug delivery, tissue bioimaging, other applications. These nanoscale hydrogels, typically ranging from 10 1000 nm, possess unique characteristics such as high water content, biocompatibility, ability encapsulate both hydrophilic hydrophobic molecules. The review explores synthesis, structural configurations, stimuli‐responsive nature nanogels, highlighting their adaptability targeted including across challenging barriers like blood–brain barrier. Furthermore, paper delves into applications particularly delivery systems, demonstrating potential revolutionize these fields. Despite promising preclinical results, challenges remain translating technologies clinical practice, issues related stability, scalability, regulatory approval. concludes by discussing future perspectives, emphasizing need further research optimize ultimately aiming enhance efficacy safety settings.

Язык: Английский

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New insights into chitosan-Ag nanocomposites synthesis: Physicochemical aspects of formation, structure-bioactivity relationship and mechanism of antioxidant activity

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140077 - 140077

Опубликована: Янв. 1, 2025

Язык: Английский

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Natural polysaccharide-small molecule smart responsive nanogels: Design, synthesis, and synergistic chemoimmunotherapy for tumors

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140930 - 140930

Опубликована: Фев. 1, 2025

Язык: Английский

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Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review

Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2024, Номер 52(1), С. 564 - 586

Опубликована: Дек. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Язык: Английский

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