Abstract
In
this
study,
the
synthesis
and
characterization
of
poly(ethyl
methacrylate‐
co
‐acrylamide)
(i.e.,
poly(EMA‐
‐AAm))
nanogels
loading
release
studies
doxorubicin
hydrochloride
were
carried
out.
The
was
out
using
emulsion
polymerization
technique
at
60
°C.
Swelling
experiments
showed
that
sensitive
to
temperature
pH
medium.
Zeta
sizer
analysis
results
synthesized
had
an
average
size
23.17
nm
PDI
value
0.270.
into
nanogels,
drug
capacity
(DLC)
nanogel
determined
as
32%
efficiency
(DLE)
77%.
Release
conducted
=
5.4
7.4
37
°C
percentage
17%
even
in
32
h
7.4,
82%
5
5.4.
different
temperatures
revealed
°C,
85%
39
89%
41
These
‐AAm)
can
be
used
targeted
controlled
increase
effects
while
reducing
side
effects.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Май 9, 2024
Hydrogels
have
emerged
as
promising
candidates
for
biomedical
applications,
especially
in
the
field
of
antibacterial
therapeutics,
due
to
their
unique
structural
properties,
highly
tunable
physicochemical
and
excellent
biocompatibility.
The
integration
stimuli-responsive
functions
into
hydrogels
holds
potential
enhance
properties
therapeutic
efficacy,
dynamically
responding
different
external
or
internal
stimuli,
such
pH,
temperature,
enzymes,
light.
Therefore,
this
review
describes
applications
hydrogel
dressings
responsive
stimuli
therapy.
collaborative
interaction
between
materials
is
discussed.
This
synergistic
approach,
contrast
conventional
materials,
not
only
amplifies
effect
but
also
alleviates
adverse
side
effects
diminishes
incidence
multiple
infections
drug
resistance.
provides
a
comprehensive
overview
current
challenges
outlines
future
research
directions
hydrogels.
It
underscores
imperative
ongoing
interdisciplinary
aimed
at
unraveling
mechanisms
wound
healing.
understanding
crucial
optimizing
design
implementation
Ultimately,
aims
offer
scientific
guidance
development
practical
clinical
application
dressings.
Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(10)
Опубликована: Окт. 1, 2024
ABSTRACT
Nanogels
represent
a
significant
innovation
in
the
fields
of
nanotechnology
and
biomedical
engineering,
combining
properties
hydrogels
nanoparticles
to
create
versatile
platforms
for
drug
delivery,
tissue
bioimaging,
other
applications.
These
nanoscale
hydrogels,
typically
ranging
from
10
1000
nm,
possess
unique
characteristics
such
as
high
water
content,
biocompatibility,
ability
encapsulate
both
hydrophilic
hydrophobic
molecules.
The
review
explores
synthesis,
structural
configurations,
stimuli‐responsive
nature
nanogels,
highlighting
their
adaptability
targeted
including
across
challenging
barriers
like
blood–brain
barrier.
Furthermore,
paper
delves
into
applications
particularly
delivery
systems,
demonstrating
potential
revolutionize
these
fields.
Despite
promising
preclinical
results,
challenges
remain
translating
technologies
clinical
practice,
issues
related
stability,
scalability,
regulatory
approval.
concludes
by
discussing
future
perspectives,
emphasizing
need
further
research
optimize
ultimately
aiming
enhance
efficacy
safety
settings.
ACS Polymers Au,
Год журнала:
2024,
Номер
4(6), С. 463 - 486
Опубликована: Авг. 20, 2024
In
recent
years,
numerous
applications
of
hydrogels
using
polysaccharides
have
evolved,
benefiting
from
their
widespread
availability,
excellent
biodegradability,
biocompatibility,
and
nonpoisonous
nature.
These
natural
polymers
are
typically
sourced
renewable
materials
or
manufacturing
processes,
contributing
collaboratively
to
waste
management
demonstrating
the
potential
for
enhanced
enduring
sustainability.
field
novel
bioactive
molecule
carriers
biotherapeutics,
attracting
attention
due
inherent
properties
adaptable
chemical
structures.
offer
versatile
matrices
with
a
range
architectures
mechanical
properties,
while
retaining
bioactivity
incorporated
biomolecules.
However,
conventional
polysaccharide-based
suffer
inadequate
toughness
large
swelling
which
prohibit
efficacy
in
real-world
applications.
This
review
offers
insights
into
latest
advancements
development
diverse
biotherapeutic
administrations,
either
standalone
conjunction
other
drug
delivery
systems,
pharmaceutical
biomedical
fields.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(5), С. 1307 - 1316
Опубликована: Янв. 1, 2024
In
this
work,
we
constructed
an
antibiotic-free
polysaccharide-based
hydrogel
dressing
(ATB)
with
near-infrared
light-actuated
on-demand
botanicals
release
and
hyperthermia
for
the
synergistic
treatment
of
wound
infections.
Molecules,
Год журнала:
2024,
Номер
29(3), С. 715 - 715
Опубликована: Фев. 4, 2024
Porous
materials
are
widely
used
as
an
effective
strategy
for
the
solubilization
of
insoluble
drugs.
In
order
to
improve
solubility
and
bioavailability
low
water-solubility
drugs,
it
is
necessary
prepare
porous
materials.
Mannitol
one
most
popular
excipients
in
food
drug
formulations.
this
study,
mannitol
was
investigated
a
carrier
water
Its
fabrication,
loading,
release
mechanisms
were
investigated.
fabricated
using
co-spray–antisolvent
process
utilizing
polyvinylpyrrolidone
K30
(PVP
K30)
template
agent.
particles
prepared
by
changing
proportion
agent,
spraying
with
mannitol,
eluting
ethanol
regulate
their
pore
structure.
subsequent
studies,
morphology
characteristics
determined
systematically.
Furthermore,
curcumin
ibuprofen,
two
poorly
water-soluble
loaded
into
profiles
analyzed.
The
results
study
indicated
that
can
be
PVP
amount
agent
adjusted
control
structure
mannitol.
When
added
amounts
1%,
3%,
5%,
size
increased
167.80%,
95.16%,
163.98%,
respectively,
compared
raw
Molecular
docking
revealed
drugs
adsorbents
adhere
each
other
force
interaction.
cumulative
dissolution
ibuprofen-loaded
reached
69%
70%,
respectively.
mechanism
ibuprofen
from
drug-loaded
suitable
Korsmeyer–Peppas
kinetic
model.
summary,
method
proved
fabricating
rapidly,
had
remarkable
effect
on
solubilization.
obtained
conducive
development
Biocatalysis and Agricultural Biotechnology,
Год журнала:
2024,
Номер
58, С. 103223 - 103223
Опубликована: Май 11, 2024
Exploring
secondary
outputs,
specifically
leftover
materials
from
steam
distillation
of
Rosmarinus
tournefortii
de
Noé,
as
agents
for
reducing
metals
introduces
a
novel
approach
to
eco-friendly
nanomaterial
production.
This
concept
aligns
with
the
creation
environmentally
conscious
nanoparticles,
showcasing
potential
across
various
fields,
notably
biomedicine.
The
paper
seamlessly
fits
into
this
context.
By
utilizing
R.
successful
synthesis
silver
nanoparticles
(AgNPs)
was
achieved,
yielding
nanoscale
variations
influenced
by
plant's
by-products.
Beyond
structural
aspects,
investigating
biomedical
applications,
focusing
on
antioxidant
and
antimicrobial
properties.
Consistently
observing
∼94.9–97.3%
scavenging
inhibition
in
water
residues
at
different
concentrations
enhanced
efficacy
against
Gram-negative
Gram-positive
bacteria
Rhodotorula
glutinis
yeast
due
these
residues.
Moreover,
thorough
examination
using
density
functional
theory
unveiled
robust
interaction
between
clusters
specific
biomolecules
found
within
residues,
namely
homoplantaginin,
protocatechuic
acid-glycoside,
caffeic,
rosmarinic
acids
(ranging
130.62
357.05
kcal/mol).
These
compounds
enhance
Ag+
ions
contribute
enduring
stability
AgNPs
(ζ
values:
-22.8
mV
-17.2
mV).
Furthermore,
study
recognizes
challenges
finding
alternative
surface
modification
explores
intricate
toxicity
mechanisms
emphasizing
their
interactions
inflammation.
Introducing
promising
nanomedicine
approaches
involving
acid
inflammatory
bowel
disease
rheumatoid
arthritis,
highlighting
rosemary
by-products
derived
innovative
therapeutic
interventions
diverse
conditions.
