International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 132031 - 132031
Опубликована: Май 3, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2023, Номер 23, С. 100823 - 100823
Опубликована: Окт. 1, 2023
Wound care and treatment can be critical from a clinical standpoint. While different strategies for the management of skin wounds have been developed, limitations inherent in current approaches necessitate development more effective alternative strategies. Advances tissue engineering resulted novel promising accelerating wound healing. The use various biomaterials capable regeneration damaged is engineering. In this regard, cerium oxide nanoparticles (CeO
Язык: Английский
Процитировано
96
Biomimetics, Год журнала: 2023, Номер 8(5), С. 442 - 442
Опубликована: Сен. 20, 2023
The field of regenerative medicine is constantly advancing and aims to repair, regenerate, or substitute impaired unhealthy tissues organs using cutting-edge approaches such as stem cell-based therapies, gene therapy, tissue engineering. Nevertheless, incorporating artificial intelligence (AI) technologies has opened new doors for research in this field. AI refers the ability machines perform tasks that typically require human ways learning patterns data applying without being explicitly programmed. potential improve accelerate various aspects development, particularly, although not exclusively, when complex are involved. This review paper provides an overview context medicine, discusses its applications with a focus on personalized highlights challenges opportunities
Язык: Английский
Процитировано
64
Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153640 - 153640
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
35
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 965 - 992
Опубликована: Янв. 1, 2024
Abstract: Diabetic wounds pose a significant challenge to public health, primarily due insufficient blood vessel supply, bacterial infection, excessive oxidative stress, and impaired antioxidant defenses. The aforementioned condition not only places physical burden on patients' prognosis, but also amplifies the economic strain medical system in treating diabetic wounds. Currently, effectiveness of available treatments for is limited. However, there hope potential metal nanoparticles (MNPs) address these issues. MNPs exhibit excellent anti-inflammatory, antioxidant, antibacterial pro-angiogenic properties, making them promising solution In addition, stimulate expression proteins that promote wound healing serve as drug delivery systems small-molecule drugs. By combining with other biomaterials such hydrogels chitosan, novel dressings can be developed revolutionize treatment present article provides comprehensive overview research progress utilization Building upon this foundation, we summarize underlying mechanisms involved discuss application delivery. Furthermore, provide an extensive analysis discussion clinical implementation dressings, while highlighting future prospects utilizing management. conclusion, represent strategy healing. Future directions include biological nanomaterials synthesize new or physicochemical properties Synthetic contain play role all stages healing, stable physiological environment wound-healing process. Keywords: nanoparticles, wound, delivery, activity
Язык: Английский
Процитировано
33
Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 300 - 300
Опубликована: Фев. 21, 2024
Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to prolonged effect. Nanomaterials have emerged promising candidates in field wound due their unique properties versatile applications. New insights into interactions between nanomaterials microenvironments shed light on mechanisms underlying therapeutic effects. However, significantly minimal amount research has been carried out see these promote process. In this review, we provided an outline various types that studied for wounds infection prevention. Overall, utilization holds great promise continues evolve, providing new opportunities development effective efficient care therapies.
Язык: Английский
Процитировано
25
Advanced Industrial and Engineering Polymer Research, Год журнала: 2024, Номер unknown
Опубликована: Май 1, 2024
Bio-based polymers have garnered significant interest across the manufacturing industry, global economy, and various engineering disciplines such as packaging, tissue engineering, controlled drug delivery, wound dressing, textiles. In current era, bio-based polymers, notably polysaccharides, offer a promising platform for constructing intricate versatile structures in biomedical sector. These encompass applications regenerative medicine (TERM), delivery devices, coatings wearable sensors, thanks to their distinctive features inherent biocompatibility, flexibility, stretchability, mechanical strength, renewability, physiological activity, favorable biological environment. this review, we concise overview of diverse types polysaccharide-based composites, properties, interactions with specific cells tissues. The review encompasses recent progress scaffolds designed cartilage, skin, neural, vascular, cardiac, bone regeneration, employing both conventional modern techniques. Additionally, it delves into development other biodegradable including systems (DDSs), antibacterial on medical electronic devices healthcare Furthermore, also elucidates research directions future perspectives while emphasizing importance regulatory approvals commitment environmental sustainability. This well-organized critical is expected assist practitioners researchers gaining deeper understanding trends, challenges, potential solutions, thereby harnessing immense biomaterials system. utilization polysaccharides sector aligns principles nature, contributing reduction carbon dioxide emissions supporting Sustainable Development Goals United Nations.
Язык: Английский
Процитировано
22
Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 327 - 327
Опубликована: Фев. 26, 2024
Bacterial infections are major problems in wound care due to their impact on the retarded process of healing, leading chronic wounds. Most presently utilized dressing products exhibit poor antimicrobial properties. Wound dressings formulated from chitosan have been reported be effective for treating infected wounds, resulting antibacterial properties chitosan. The chitosan-based can further enhanced by incorporating metallic nanoparticles into them, such as silver, zinc, titanium, etc. incorporation silver has widely explored design dressings. promotes accelerated wound-healing processes activity. healing these metal-based is via regulation re-epithelialization and inflammation without affecting viability normal cells. However, there few reports that evaluate infectious animal models prove efficacy. vivo toxicity still needs addressed, revealing need preclinical clinical trials. fabrication incorporated with not fully explored, especially wounds requiring immediate treatment. possible interactions between scaffolds result synergistic effects understood studied. This review provides a comprehensive report outcomes materials loaded managing
Язык: Английский
Процитировано
21
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 27, 2024
Abstract The development of innovative wound dressing materials is crucial for effective care. It’s an active area research driven by a better understanding chronic pathogenesis. Addressing care properly clinical challenge, but there growing demand advancements in this field. synergy medicinal plants and nanotechnology offers promising approach to expedite the healing process both acute wounds facilitating appropriate progression through various phases. Metal nanoparticles play increasingly pivotal role promoting efficient preventing secondary bacterial infections. Their small size high surface facilitate enhanced biological interaction penetration at site. Specifically designed topical drug delivery, these enable sustained release therapeutic molecules, such as growth factors antibiotics. This targeted ensures optimal cell-to-cell interactions, proliferation, vascularization, fostering controlled healing. Nanoscale scaffolds have significant attention due their attractive properties, including delivery capacity, porosity area. They mimic Extracellular matrix (ECM) hence biocompatible. In response alarming rise antibiotic-resistant, biohybrid nanofibrous dressings are gradually replacing conventional antibiotic systems. emerging class comprises biopolymeric nanofibers with inherent antibacterial nature-derived compounds, biofunctional agents. Nanotechnology, diminutive nanomaterials, nanoscaffolds, nanofibers, biomaterials harnessed aimed review article discusses effects loaded on healing, (in vivo vitro) mechanical outcomes. Graphical
Язык: Английский
Процитировано
19
Burns & Trauma, Год журнала: 2025, Номер 13
Опубликована: Янв. 1, 2025
Abstract Effective wound management and treatment are crucial in clinical practice, yet existing strategies often fall short fully addressing the complexities of skin healing. Recent advancements tissue engineering have introduced innovative approaches, particularly through use nanobiomaterials, to enhance healing process. In this context, titanium dioxide nanoparticles (TiO2 NPs) garnered attention due their excellent biological properties, including antioxidant, anti-inflammatory, antimicrobial properties. Furthermore, these can be modified therapeutic benefits. Scaffolds dressings containing TiO2 NPs demonstrated promising outcomes accelerating enhancing regeneration. This review paper covers process, properties that make them suitable for promoting healing, methods synthesizing NPs, scaffolds application potential toxicity NPs.
Язык: Английский
Процитировано
3
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 256, С. 128458 - 128458
Опубликована: Ноя. 26, 2023
Язык: Английский
Процитировано
27