Updates on Biogenic Metallic and Metal Oxide Nanoparticles: Therapy, Drug Delivery and Cytotoxicity

Pharmaceutics, Год журнала: 2023, Номер 15(6), С. 1650 - 1650

Опубликована: Июнь 3, 2023

The ambition to combat the issues affecting environment and human health triggers development of biosynthesis that incorporates production natural compounds by living organisms via eco-friendly nano assembly. Biosynthesized nanoparticles (NPs) have various pharmaceutical applications, such as tumoricidal, anti-inflammatory, antimicrobials, antiviral, etc. When combined, bio-nanotechnology drug delivery give rise pharmaceutics with site-specific biomedical applications. In this review, we attempted summarize in brief types renewable biological systems used for metallic metal oxide NPs vital contribution biogenic carriers simultaneously. biosystem assembly further affects morphology, size, shape, structure produced nanomaterial. toxicity NPs, because their pharmacokinetic behavior vitro vivo, is also discussed, together some recent achievements towards enhanced biocompatibility, bioavailability, reduced side effects. Because large biodiversity, potential application extracts nanomedicine yet be explored.

Язык: Английский

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Silk fibroin-based scaffolds for wound healing applications with metal oxide nanoparticles

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 96, С. 105689 - 105689

Опубликована: Апрель 21, 2024

In the last few years, wound healing and development of "ideal" biomaterials that provide quick recovery minimize scarring have represented one most important priorities researchers. this direction, silk fibroin (SF) scaffolds gained substantial awareness, as a promising polymer owing to their increased biocompatibility, outstanding mechanical properties, biodegradability, especially tensile strength. Furthermore, SF is acknowledged accelerate process by encouraging cell growth proliferation, also migration different types cells are included in stages process. Therefore, metal oxide nanoparticles (NPs), such iron (FeO), copper (CuO), zinc (ZnO), or magnesium (MgO) NPs, been extensively researched for antimicrobial properties ability enhance tissue regeneration addition SF. When introduced within scaffolds, these NPs impart enhanced including improved scaffold stability durability. Moreover, presence could increase biocompatibility facilitating adhesion, migration, ultimately promoting processes. The incorporation other natural polymers into has thus emerged favorable method therapeutic potential developed biomaterial. This review aims an overview advancements containing applications.

Язык: Английский

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Stimuli-responsive chitosan-based nanocarriers for drug delivery in wound dressing applications: A review

Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер 7, С. 100497 - 100497

Опубликована: Апрель 6, 2024

Wound care poses a significant global challenge, imposing substantial financial strain on governments across the globe. The exploration of wound dressings (WDs) with potential to enhance healing process has been subject extensive research and scrutiny for an extended period. Traditional dressings, such as bandages, hydrogels, foams, fall short achieving desired (WH) outcomes due their limited ability accurately address dynamic tissue repair. There have suggestions create sophisticated WDs capability interact wounds, perceive alterations in wound's state or surroundings, react correspondingly. This proposal encompasses development advanced that possess interactive features improved monitoring response changes conditions. These innovative incorporate sensors intelligent materials stimuli-responsive self-healing materials, aiming effectively WH. In recent years, there advancement field WDs, introduction smart WDs. cutting-edge include biomechanical mobile injuries, self-removable progressive technology showcases revolutionize management treatment various types wounds. review aims provide overview chitosan nanoparticles (CS NPs) exhibit responsiveness stimuli. article discusses aspects these focusing characteristics applications scientific scholarly manner.

Язык: Английский

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Nano-Chitosan/Eucalyptus Oil/Cellulose Acetate Nanofibers: Manufacturing, Antibacterial and Wound Healing Activities

Membranes, Год журнала: 2023, Номер 13(6), С. 604 - 604

Опубликована: Июнь 15, 2023

Accelerated wound healing in infected skin is still one of the areas where current therapeutic tactics fall short, which highlights critical necessity for exploration new approaches. The present study aimed to encapsulate Eucalyptus oil a nano-drug carrier enhance its antimicrobial activity. Furthermore, vitro, and vivo studies novel nano-chitosan/Eucalyptus oil/cellulose acetate electrospun nanofibers were investigated. showed potent activity against tested pathogens highest inhibition zone diameter, MIC, MBC (15.3 mm, 16.0 μg/mL, 256 respectively) recorded Staphylococcus aureus. Data indicated three-fold increase encapsulated chitosan nanoparticle (43 mm diameter S. aureus). biosynthesized nanoparticles had 48.26 nm particle size, 19.0 mV zeta potential, 0.45 PDI. Electrospinning was conducted, physico-chemical biological properties revealed that synthesized homogenous, with thin (98.0 nm) significantly high vitro cytotoxic effect human normal melanocyte cell line (HFB4) proved an 80% viability using 1.5 mg/mL nanofibers. In safe efficiently enhanced wound-healing process through enhancing TGF-β, type I III collagen production. As conclusion, manufactured nanofiber effective potentiality use as dressing.

Язык: Английский

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New insights into biomaterials for wound dressings and care: Challenges and trends

Progress in Organic Coatings, Год журнала: 2023, Номер 187, С. 108118 - 108118

Опубликована: Дек. 1, 2023

Язык: Английский

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Wound Gel with Antimicrobial Effects Based on Polyvinyl Alcohol and Functional Aryloxycyclotriphosphazene

Polymers, Год журнала: 2023, Номер 15(13), С. 2831 - 2831

Опубликована: Июнь 27, 2023

A silver-containing gel based on polyvinyl alcohol and aryloxycyclotriphosphazene containing β-carboxyethenylphenoxy p-formylphenoxy groups has been developed. Phosphazene was synthesized via the Doebner reaction from hexakis[(4-formyl)phenoxy]cyclotriphosphazene malonic acid characterized by 1H, 13C, 31P NMR spectroscopy MALDI-TOF mass spectrometry. The study of using scanning electron microscopy showed that contains open pores can absorb wound exudate. maximum water absorption capacity 272%, which reached after 80 min testing. antimicrobial activity obtained evaluated diffusion method. found to inhibit growth main microorganisms in contact with skin: bacteria S. aureus, P. aeruginosa, E. coli, B. subtilis, epidermidis, C. stationis fungus albicans. wound-healing effect vivo a decrease area rabbit hind limb 91.43% (p < 0.05) 10th day observation content C-reactive protein blood serum 1.3 times 0.05).

Язык: Английский

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Synthesis and evaluation of berberine loaded chitosan nanocarrier for enhanced in-vitro antioxidant and anti-inflammatory potential

Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер 7, С. 100474 - 100474

Опубликована: Март 5, 2024

Berberine, a naturally occurring isoquinoline plant alkaloid molecule, finds application in traditional medicine due to its extensive pharmacological effects but it cannot be clinically exploited fullest as possesses poor water solubility and bioavailability. In order address this issue, we have synthesized berberine loaded chitosan nanoparticles (BCNPs) using DMSO surfactant polymer modified ionic complexation approach optimized the process utilizing central composite design. The BCNPs were empirically assessed for various parameters such particle size distribution, zeta potential, drug encapsulation efficiency, surface morphology established methodologies. additionally in-vitro antibacterial activity, antioxidant anti-inflammatory sustained release behavior techniques. Experimental results showed that at concentration of 0.05% (w/v) 1% (v/v) successfully generated with spherical shape ranging from 20 60 nm exhibited stabilizing potential 26.1 mV. Additionally, they had high effectiveness 94.01%. Sustained was observed 74.30% released 48 h, respectively BCNPs. antimicrobial assays reveal exhibit superior against all bacterial strains compared alone determined by agar well diffusion method. also substantial rise DPPH activity greater percentage protection berberine. summary, our research suggests nanocarrier can enhance facilitate development novel naturally-derived antioxidants compounds. This study will further provide an insight into future natural discovery.

Язык: Английский

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Polysaccharide-based polyelectrolyte multilayers fabricated via layer-by-layer approach: From preparation to applications

Progress in Organic Coatings, Год журнала: 2024, Номер 196, С. 108720 - 108720

Опубликована: Авг. 2, 2024

Язык: Английский

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Novel Microemulsion Containing Benzocaine and Fusidic Acid Simultaneously: Formulation, Characterization, and In Vitro Evaluation for Wound Healing

AAPS PharmSciTech, Год журнала: 2024, Номер 25(3)

Опубликована: Март 5, 2024

Abstract Modern drug carrier technologies, such as microemulsions with small droplet sizes and high surface areas, improve the ability of low water solubility active ingredients to permeate localize. The goal this study was create microemulsion formulations for wound healing that contained both fusidic acid (FA), an antibacterial agent, benzocaine (BNZ), a local anesthetic. Studies on characterization were carried out, including viscosity, size, zeta potential. drug-loaded had stable structure –3.014 ± 1.265 mV potential 19.388 0.480 nm size. In in vitro release ex vivo permeability studies, compared Fucidin cream oily BNZ solution. According from solution showed similar profile ( p > 0.05), while FA higher < 0.001). presented lower permeation 0.05) ingredients, other hand, provided accumulation control preparations. Moreover, according results activity, indicated dose-dependent highest activity at concentrations. To best our knowledge, developed BNZ- FA-loaded would be promising candidate new opportunities thanks present which have solubility, single formulation achieved than Graphical

Язык: Английский

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Fabrication and characterization of porous pectin-based aerogels for drug delivery

Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер 7, С. 100499 - 100499

Опубликована: Апрель 10, 2024

Aerogels are renowned for their exceptional characteristics such as high porosity and ultra-low density. Among these, pectin aerogels, offering biodegradability, low toxicity, versatility, prominent candidates innovative biomedical materials. This study focused on synthesizing pectin-based aerogels carriers ibuprofen diclofenac sodium. Hydrogels were formed by combining a methoxy with calcium chloride solution, followed dehydration drying using either supercritical carbon dioxide (scCO2) or freeze-drying. Comparative analysis showed scCO2-dried exhibited slightly less shrinkage (0.27%) than freeze-dried counterparts. Both types mesoporous characteristics. However, demonstrated higher specific surface area, pore volume, smaller diameter. FTIR spectra indicated no interaction between the drugs aerogels. The loading of in scCO2-dried, at 90, 95, 100 bar 60.0%, 59.9%, 52.1%, respectively, solution sodium was 38.37%. At bar, ibuprofen-loaded released 90.0%, 84.0%, 75.5%, respectively. release sodium-loaded, 88.4%. Korsmeyer-Peppas model fitted both sodium, indicating is mainly driven diffusion.

Язык: Английский

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