Carbohydrate Polymer Technologies and Applications,
Journal Year:
2023,
Volume and Issue:
7, P. 100406 - 100406
Published: Dec. 10, 2023
The
extract
of
Citrus
aurantifolia
peel
has
been
encapsulated
into
alginate-gelatin-based
microbeads
using
an
external
ionotropic
gelation
method
to
apply
antibacterial
wound
dressings.
Such
variables,
like
the
alginate-gelatin
ratio,
quantity,
and
CaCl2
cross-linkers,
were
optimized
produce
a
good
yield,
well-distributed
size,
encapsulation
efficiency.
Antibacterial
efficacy
was
tested
against
both
S.
aureus
E.
coli.
Optimal
microbead
characteristics
obtained
at
alginate:gelatin
concentration
ratio
1.75%:0.25%
(w/v),
with
15
mg
2%
cross-linker.
These
conditions
resulted
in
82.94
±
1.056%
particle
sizes
between
1.080-1.244
µm,
efficiency
79.127
0.186%.
exhibited
almost
spherical
morphology
slightly
rough
surface.
release
mechanism
out
governed
by
diffusion
erosion
shells
following
Korsmeyer-Peppas
kinetic
model
(k=1.014
0.007/min).
Upon
immobilizing
on
gauze,
add-on
percentage
73.98%
observed.
Moreover,
gauze-immobilized
inhibited
coli
growth
inhibition
zones
11±1.48
12.56±4.89
mm,
respectively.
In
conclusion,
have
demonstrated
optimal
effective
coli,
showcasing
their
potential
as
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
96, P. 105689 - 105689
Published: April 21, 2024
In
the
last
few
years,
wound
healing
and
development
of
"ideal"
biomaterials
that
provide
quick
recovery
minimize
scarring
have
represented
one
most
important
priorities
researchers.
this
direction,
silk
fibroin
(SF)
scaffolds
gained
substantial
awareness,
as
a
promising
polymer
owing
to
their
increased
biocompatibility,
outstanding
mechanical
properties,
biodegradability,
especially
tensile
strength.
Furthermore,
SF
is
acknowledged
accelerate
process
by
encouraging
cell
growth
proliferation,
also
migration
different
types
cells
are
included
in
stages
process.
Therefore,
metal
oxide
nanoparticles
(NPs),
such
iron
(FeO),
copper
(CuO),
zinc
(ZnO),
or
magnesium
(MgO)
NPs,
been
extensively
researched
for
antimicrobial
properties
ability
enhance
tissue
regeneration
addition
SF.
When
introduced
within
scaffolds,
these
NPs
impart
enhanced
including
improved
scaffold
stability
durability.
Moreover,
presence
could
increase
biocompatibility
facilitating
adhesion,
migration,
ultimately
promoting
processes.
The
incorporation
other
natural
polymers
into
has
thus
emerged
favorable
method
therapeutic
potential
developed
biomaterial.
This
review
aims
an
overview
advancements
containing
applications.
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
7, P. 100497 - 100497
Published: April 6, 2024
Wound
care
poses
a
significant
global
challenge,
imposing
substantial
financial
strain
on
governments
across
the
globe.
The
exploration
of
wound
dressings
(WDs)
with
potential
to
enhance
healing
process
has
been
subject
extensive
research
and
scrutiny
for
an
extended
period.
Traditional
dressings,
such
as
bandages,
hydrogels,
foams,
fall
short
achieving
desired
(WH)
outcomes
due
their
limited
ability
accurately
address
dynamic
tissue
repair.
There
have
suggestions
create
sophisticated
WDs
capability
interact
wounds,
perceive
alterations
in
wound's
state
or
surroundings,
react
correspondingly.
This
proposal
encompasses
development
advanced
that
possess
interactive
features
improved
monitoring
response
changes
conditions.
These
innovative
incorporate
sensors
intelligent
materials
stimuli-responsive
self-healing
materials,
aiming
effectively
WH.
In
recent
years,
there
advancement
field
WDs,
introduction
smart
WDs.
cutting-edge
include
biomechanical
mobile
injuries,
self-removable
progressive
technology
showcases
revolutionize
management
treatment
various
types
wounds.
review
aims
provide
overview
chitosan
nanoparticles
(CS
NPs)
exhibit
responsiveness
stimuli.
article
discusses
aspects
these
focusing
characteristics
applications
scientific
scholarly
manner.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1650 - 1650
Published: June 3, 2023
The
ambition
to
combat
the
issues
affecting
environment
and
human
health
triggers
development
of
biosynthesis
that
incorporates
production
natural
compounds
by
living
organisms
via
eco-friendly
nano
assembly.
Biosynthesized
nanoparticles
(NPs)
have
various
pharmaceutical
applications,
such
as
tumoricidal,
anti-inflammatory,
antimicrobials,
antiviral,
etc.
When
combined,
bio-nanotechnology
drug
delivery
give
rise
pharmaceutics
with
site-specific
biomedical
applications.
In
this
review,
we
attempted
summarize
in
brief
types
renewable
biological
systems
used
for
metallic
metal
oxide
NPs
vital
contribution
biogenic
carriers
simultaneously.
biosystem
assembly
further
affects
morphology,
size,
shape,
structure
produced
nanomaterial.
toxicity
NPs,
because
their
pharmacokinetic
behavior
vitro
vivo,
is
also
discussed,
together
some
recent
achievements
towards
enhanced
biocompatibility,
bioavailability,
reduced
side
effects.
Because
large
biodiversity,
potential
application
extracts
nanomedicine
yet
be
explored.
Membranes,
Journal Year:
2023,
Volume and Issue:
13(6), P. 604 - 604
Published: June 15, 2023
Accelerated
wound
healing
in
infected
skin
is
still
one
of
the
areas
where
current
therapeutic
tactics
fall
short,
which
highlights
critical
necessity
for
exploration
new
approaches.
The
present
study
aimed
to
encapsulate
Eucalyptus
oil
a
nano-drug
carrier
enhance
its
antimicrobial
activity.
Furthermore,
vitro,
and
vivo
studies
novel
nano-chitosan/Eucalyptus
oil/cellulose
acetate
electrospun
nanofibers
were
investigated.
showed
potent
activity
against
tested
pathogens
highest
inhibition
zone
diameter,
MIC,
MBC
(15.3
mm,
16.0
μg/mL,
256
respectively)
recorded
Staphylococcus
aureus.
Data
indicated
three-fold
increase
encapsulated
chitosan
nanoparticle
(43
mm
diameter
S.
aureus).
biosynthesized
nanoparticles
had
48.26
nm
particle
size,
19.0
mV
zeta
potential,
0.45
PDI.
Electrospinning
was
conducted,
physico-chemical
biological
properties
revealed
that
synthesized
homogenous,
with
thin
(98.0
nm)
significantly
high
vitro
cytotoxic
effect
human
normal
melanocyte
cell
line
(HFB4)
proved
an
80%
viability
using
1.5
mg/mL
nanofibers.
In
safe
efficiently
enhanced
wound-healing
process
through
enhancing
TGF-β,
type
I
III
collagen
production.
As
conclusion,
manufactured
nanofiber
effective
potentiality
use
as
dressing.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(13), P. 2831 - 2831
Published: June 27, 2023
A
silver-containing
gel
based
on
polyvinyl
alcohol
and
aryloxycyclotriphosphazene
containing
β-carboxyethenylphenoxy
p-formylphenoxy
groups
has
been
developed.
Phosphazene
was
synthesized
via
the
Doebner
reaction
from
hexakis[(4-formyl)phenoxy]cyclotriphosphazene
malonic
acid
characterized
by
1H,
13C,
31P
NMR
spectroscopy
MALDI-TOF
mass
spectrometry.
The
study
of
using
scanning
electron
microscopy
showed
that
contains
open
pores
can
absorb
wound
exudate.
maximum
water
absorption
capacity
272%,
which
reached
after
80
min
testing.
antimicrobial
activity
obtained
evaluated
diffusion
method.
found
to
inhibit
growth
main
microorganisms
in
contact
with
skin:
bacteria
S.
aureus,
P.
aeruginosa,
E.
coli,
B.
subtilis,
epidermidis,
C.
stationis
fungus
albicans.
wound-healing
effect
vivo
a
decrease
area
rabbit
hind
limb
91.43%
(p
<
0.05)
10th
day
observation
content
C-reactive
protein
blood
serum
1.3
times
0.05).
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
7, P. 100474 - 100474
Published: March 5, 2024
Berberine,
a
naturally
occurring
isoquinoline
plant
alkaloid
molecule,
finds
application
in
traditional
medicine
due
to
its
extensive
pharmacological
effects
but
it
cannot
be
clinically
exploited
fullest
as
possesses
poor
water
solubility
and
bioavailability.
In
order
address
this
issue,
we
have
synthesized
berberine
loaded
chitosan
nanoparticles
(BCNPs)
using
DMSO
surfactant
polymer
modified
ionic
complexation
approach
optimized
the
process
utilizing
central
composite
design.
The
BCNPs
were
empirically
assessed
for
various
parameters
such
particle
size
distribution,
zeta
potential,
drug
encapsulation
efficiency,
surface
morphology
established
methodologies.
additionally
in-vitro
antibacterial
activity,
antioxidant
anti-inflammatory
sustained
release
behavior
techniques.
Experimental
results
showed
that
at
concentration
of
0.05%
(w/v)
1%
(v/v)
successfully
generated
with
spherical
shape
ranging
from
20
60
nm
exhibited
stabilizing
potential
26.1
mV.
Additionally,
they
had
high
effectiveness
94.01%.
Sustained
was
observed
74.30%
released
48
h,
respectively
BCNPs.
antimicrobial
assays
reveal
exhibit
superior
against
all
bacterial
strains
compared
alone
determined
by
agar
well
diffusion
method.
also
substantial
rise
DPPH
activity
greater
percentage
protection
berberine.
summary,
our
research
suggests
nanocarrier
can
enhance
facilitate
development
novel
naturally-derived
antioxidants
compounds.
This
study
will
further
provide
an
insight
into
future
natural
discovery.
AAPS PharmSciTech,
Journal Year:
2024,
Volume and Issue:
25(3)
Published: March 5, 2024
Abstract
Modern
drug
carrier
technologies,
such
as
microemulsions
with
small
droplet
sizes
and
high
surface
areas,
improve
the
ability
of
low
water
solubility
active
ingredients
to
permeate
localize.
The
goal
this
study
was
create
microemulsion
formulations
for
wound
healing
that
contained
both
fusidic
acid
(FA),
an
antibacterial
agent,
benzocaine
(BNZ),
a
local
anesthetic.
Studies
on
characterization
were
carried
out,
including
viscosity,
size,
zeta
potential.
drug-loaded
had
stable
structure
–3.014
±
1.265
mV
potential
19.388
0.480
nm
size.
In
in
vitro
release
ex
vivo
permeability
studies,
compared
Fucidin
cream
oily
BNZ
solution.
According
from
solution
showed
similar
profile
(
p
>
0.05),
while
FA
higher
<
0.001).
presented
lower
permeation
0.05)
ingredients,
other
hand,
provided
accumulation
control
preparations.
Moreover,
according
results
activity,
indicated
dose-dependent
highest
activity
at
concentrations.
To
best
our
knowledge,
developed
BNZ-
FA-loaded
would
be
promising
candidate
new
opportunities
thanks
present
which
have
solubility,
single
formulation
achieved
than
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