Food Chemistry, Год журнала: 2024, Номер 466, С. 142210 - 142210
Опубликована: Ноя. 26, 2024
Язык: Английский
Heliyon, Год журнала: 2024, Номер 10(21), С. e39632 - e39632
Опубликована: Окт. 22, 2024
The efficacy of dasatinib (DAS) in treating hepatocellular carcinoma (HCC) is hindered by its poor bioavailability, limiting clinical potential. In this study, we explored the use TPGS-Soluplus micelles as an innovative drug delivery platform to enhance DAS solubility, stability, and therapeutic impact. A series copolymers were synthesized, varying D-α-tocopheryl polyethylene glycol succinate (TPGS) forms (1000, 2000, 3500) adjusting TPGS Soluplus weight ratios (1:1, 1:2, 1:3). Our goal was identify optimal formulation with highest entrapment efficiency, smallest particle size, enhanced loading. TPGS1000-Soluplus copolymer, a DAS-to-polymer ratio 1:30 demonstrated superior performance, achieving efficiency 64.479 ± 1.45 % loading 5.05 1.01 %. DAS-loaded (DAS-PMs) exhibited notably small size nm controlled release kinetics, 85.60 5.4 released over 72 h. Cellular uptake studies using Hep G2 cells revealed significantly absorption DAS-PMs compared free DAS, reflected lower IC50 values MTT assays at 24 48 Pharmacokinetic analysis further highlighted benefits DAS-PMs, AUC0-∞ 2.16 times higher mean residual time (MRT) 1.3 longer than statistically significant improvement (p < 0.01). These findings suggest that offer promising strategy for improving bioavailability HCC treatment, presenting potential new avenue patients limited options. This could delivery, potentially leading improved outcomes liver cancer therapy.
Язык: Английский
Процитировано
9
Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
ABSTRACT Core‐shell nanofibers have the potential to surpass traditional monolithic electrospun in drug delivery, due their ability encapsulate sensitive therapeutics within core, protect them from degradation, and enable controlled release profiles through shell. When designed be stimuli‐responsive, these evolve “smart” delivery platforms for advanced therapeutic applications. This mini‐review examines recent advancements fabrication applications of stimuli‐responsive core‐shell nanofibers. Key techniques, such as coaxial electrospinning, single‐nozzle electrospinning using water‐in‐oil or oil‐in‐water emulsions immiscible blends (e.g., polyethylene oxide chitosan; polyvinylpyrrolidone polyvinylidene), needleless post‐fabrication coating methods, are discussed along with respective advantages limitations. Additionally, review also explores how can engineered respond stimuli like near‐infrared (NIR) light, ultrasound, temperature, pH changes. Representative examples illustrate reduce initial burst release, on‐demand chemodrug implement photothermal therapy against cancer cells. At end, we offer perspectives on challenges, opportunities, new directions future development.
Язык: Английский
Процитировано
0
Medicine in Novel Technology and Devices, Год журнала: 2025, Номер unknown, С. 100352 - 100352
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Pharmacology & Translational Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
IFMBE proceedings, Год журнала: 2025, Номер unknown, С. 65 - 75
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nanomedicine, Год журнала: 2024, Номер 19(6), С. 459 - 481
Опубликована: Янв. 15, 2024
Aim: Encapsulating epigallocatechin-3-gallate (EGCG) in pH-sensitive polymeric nanoparticles for targeted delivery of drugs could revolutionize colorectal cancer treatment. Materials & methods: Nanoparticles were synthesized to release at colon pH. Dynamic light scattering measured their average diameter and ζ-potential, while differential scanning calorimetry x-ray diffraction assessed EGCG encapsulation. Results: The showed stability bioavailability the gastrointestinal tract, efficiently encapsulating releasing over 93% pH 7.2. They enhanced cytotoxicity against HT-29 cells demonstrated antibacterial properties, increasing apoptosis cell cycle arrest. Conclusion: study underscores potential enhancing therapy, aiming minimize side effects improve therapeutic outcomes.
Язык: Английский
Процитировано
3
International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 125135 - 125135
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
3
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 495 - 511
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
2
Molecules, Год журнала: 2023, Номер 28(20), С. 7215 - 7215
Опубликована: Окт. 22, 2023
This work aimed to study the influence of polybutylene succinate (PBS) content on physical, thermal, mechanical, and chemical properties obtained polylactic acid (PLA)/PBS composite fibers. PLA/PBS blend fibers were prepared by a simple melt-blown process capable yielding nanofibers. Morphological analysis revealed that fiber size was irregular discontinuous in length. Including PBS affected distribution, had smoother surface with increased amounts added PBS. Differential scanning calorimetry (DSC) crystallization temperature PLA sheet (105.8 °C) decreased increasing addition levels down 91.7 °C at 10 wt.% suggests may affect crystallization, which is consistent X-ray diffraction crystallinity (19.2%) up 28.1% wt% Moreover, adding tensile while % elongation break significantly decreased.
Язык: Английский
Процитировано
2