Advances in prebiotic carbohydrate–based targeted delivery: Overcoming gastrointestinal challenges for bioactive ingredients DOI
Yunzhen Zhang,

Jian He,

Hong Zeng

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 466, P. 142210 - 142210

Published: Nov. 26, 2024

Language: Английский

Development, Optimization, and Characterization of Polymeric Micelles to Improve Dasatinib Oral Bioavailability: Hep G2 Cell Cytotoxicity and In Vivo Pharmacokinetics for Targeted Liver Cancer Therapy DOI Creative Commons
R. Shaikh, Sankha Bhattacharya, Suprit D. Saoji

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39632 - e39632

Published: Oct. 22, 2024

The efficacy of dasatinib (DAS) in treating hepatocellular carcinoma (HCC) is hindered by its poor bioavailability, limiting clinical potential. In this study, we explored the use TPGS-Soluplus micelles as an innovative drug delivery platform to enhance DAS solubility, stability, and therapeutic impact. A series copolymers were synthesized, varying D-α-tocopheryl polyethylene glycol succinate (TPGS) forms (1000, 2000, 3500) adjusting TPGS Soluplus weight ratios (1:1, 1:2, 1:3). Our goal was identify optimal formulation with highest entrapment efficiency, smallest particle size, enhanced loading. TPGS1000-Soluplus copolymer, a DAS-to-polymer ratio 1:30 demonstrated superior performance, achieving efficiency 64.479 ± 1.45 % loading 5.05 1.01 %. DAS-loaded (DAS-PMs) exhibited notably small size nm controlled release kinetics, 85.60 5.4 released over 72 h. Cellular uptake studies using Hep G2 cells revealed significantly absorption DAS-PMs compared free DAS, reflected lower IC50 values MTT assays at 24 48 Pharmacokinetic analysis further highlighted benefits DAS-PMs, AUC0-∞ 2.16 times higher mean residual time (MRT) 1.3 longer than statistically significant improvement (p < 0.01). These findings suggest that offer promising strategy for improving bioavailability HCC treatment, presenting potential new avenue patients limited options. This could delivery, potentially leading improved outcomes liver cancer therapy.

Language: Английский

Citations

8
Corchorus Olitorius (Jute) Fiber Enforced Sustainable Polymeric Dressing Material for Antimicrobial Activity DOI Creative Commons

Gupta Swati Sanjaykumar,

Rishabha Malviya, Dhanalekshmi Unnikrishnan Meenakshi

et al.

Medicine in Novel Technology and Devices, Journal Year: 2025, Volume and Issue: unknown, P. 100352 - 100352

Published: Feb. 1, 2025

Language: Английский

Citations

0
Stimuli‐Responsive Core‐Shell Electrospun Nanofibers for Drug Delivery: A Mini‐Review DOI Creative Commons

Songpei Xie,

Jing Zhang,

Chase Orf

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

ABSTRACT Core‐shell nanofibers have the potential to surpass traditional monolithic electrospun in drug delivery, due their ability encapsulate sensitive therapeutics within core, protect them from degradation, and enable controlled release profiles through shell. When designed be stimuli‐responsive, these evolve “smart” delivery platforms for advanced therapeutic applications. This mini‐review examines recent advancements fabrication applications of stimuli‐responsive core‐shell nanofibers. Key techniques, such as coaxial electrospinning, single‐nozzle electrospinning using water‐in‐oil or oil‐in‐water emulsions immiscible blends (e.g., polyethylene oxide chitosan; polyvinylpyrrolidone polyvinylidene), needleless post‐fabrication coating methods, are discussed along with respective advantages limitations. Additionally, review also explores how can engineered respond stimuli like near‐infrared (NIR) light, ultrasound, temperature, pH changes. Representative examples illustrate reduce initial burst release, on‐demand chemodrug implement photothermal therapy against cancer cells. At end, we offer perspectives on challenges, opportunities, new directions future development.

Language: Английский

Citations

0
Innovative Immunotherapy and Its Transformative Impact on Gastric Adenocarcinoma: A Comprehensive Review of the Disease’s Origins, Epidemiology, Classification, Diagnosis, and Treatment Options DOI

Upasana Upasana,

Abhishek Kanugo, Sankha Bhattacharya

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
pH-Sensitive Nanoparticles of Epigallocatechin-3-Gallate in Enhanced Colorectal Cancer Therapy DOI
Sankha Bhattacharya, Preeti C. Sangave, Sateesh Belemkar

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(6), P. 459 - 481

Published: Jan. 15, 2024

Aim: Encapsulating epigallocatechin-3-gallate (EGCG) in pH-sensitive polymeric nanoparticles for targeted delivery of drugs could revolutionize colorectal cancer treatment. Materials & methods: Nanoparticles were synthesized to release at colon pH. Dynamic light scattering measured their average diameter and ζ-potential, while differential scanning calorimetry x-ray diffraction assessed EGCG encapsulation. Results: The showed stability bioavailability the gastrointestinal tract, efficiently encapsulating releasing over 93% pH 7.2. They enhanced cytotoxicity against HT-29 cells demonstrated antibacterial properties, increasing apoptosis cell cycle arrest. Conclusion: study underscores potential enhancing therapy, aiming minimize side effects improve therapeutic outcomes.

Language: Английский

Citations

3
Synthetic fibers and their composites for biomedical applications DOI

J. Arulmozhivarman,

L. Rajeshkumar,

Madheswaran Dinesh Kumar

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 495 - 511

Published: Jan. 1, 2024

Language: Английский

Citations

2
Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals DOI

Hadeer M. Morsy,

Mohamed Y. Zaky, Nour Y. S. Yassin

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125135 - 125135

Published: Dec. 1, 2024

Language: Английский

Citations

2
Effect of Polybutylene Succinate Additive in Polylactic Acid Blend Fibers via a Melt-Blown Process DOI Creative Commons

Benchamaporn Tangnorawich,

Areerut Magmee,

Nanjaporn Roungpaisan

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7215 - 7215

Published: Oct. 22, 2023

This work aimed to study the influence of polybutylene succinate (PBS) content on physical, thermal, mechanical, and chemical properties obtained polylactic acid (PLA)/PBS composite fibers. PLA/PBS blend fibers were prepared by a simple melt-blown process capable yielding nanofibers. Morphological analysis revealed that fiber size was irregular discontinuous in length. Including PBS affected distribution, had smoother surface with increased amounts added PBS. Differential scanning calorimetry (DSC) crystallization temperature PLA sheet (105.8 °C) decreased increasing addition levels down 91.7 °C at 10 wt.% suggests may affect crystallization, which is consistent X-ray diffraction crystallinity (19.2%) up 28.1% wt% Moreover, adding tensile while % elongation break significantly decreased.

Language: Английский

Citations

2
Modeling the Impact of Deforestation on Global Warming using System Dynamics DOI Creative Commons

Balpreet Singh,

Valerie Reddy, K. Ramakrishna Reddy

et al.

E3S Web of Conferences, Journal Year: 2024, Volume and Issue: 581, P. 01023 - 01023

Published: Jan. 1, 2024

This study aims to analyze the evolving dynamics of environmental sustainability via a thorough investigation deforestation, atmospheric carbon levels, ecological equilibrium, and global climate trends. A conclusion reached is that positive association exists between deforestation increasing temperatures, shown by twenty percent rise in CO2 emissions. The loss forests has markedly contributed imbalance, leading detrimental impacts on biodiversity, with total increase fifteen habitat damage. Initiatives aimed at reducing have resulted major 10% decrease absorption rates, emphasizing forest regeneration diminishing sequestration capabilities. focus degradation ecosystems, illustrating collective struggle, 12% reduction coverage 15% warming indices. These discoveries enhance knowledge changes may impact future systems. Furthermore, they provide crucial direction for policy-makers establish basis further research initiatives.

Language: Английский

Citations

0
Advances in prebiotic carbohydrate–based targeted delivery: Overcoming gastrointestinal challenges for bioactive ingredients DOI
Yunzhen Zhang,

Jian He,

Hong Zeng

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 466, P. 142210 - 142210

Published: Nov. 26, 2024

Language: Английский

Citations

0