Synergizing sustainable green nanotechnology and AI/ML for advanced nanocarriers: A paradigm shift in the treatment of neurodegenerative diseases

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 373 - 397

Опубликована: Ноя. 29, 2024

Язык: Английский

A Brief Review on Layered Double Hydroxides (LDH): Innovative Non‐Viral Carriers for Nucleic Acid Delivery

ChemistrySelect, Год журнала: 2025, Номер 10(16)

Опубликована: Апрель 1, 2025

Abstract Layered double hydroxides (LDHs) are emerging as versatile, nonviral vectors for gene delivery, offering significant potential in therapeutic applications. Their structure comprises positively charged metal hydroxide layers intercalated with anions, enabling efficient encapsulation of genetic materials like plasmids, small interfering RNA (siRNA), and messenger (mRNA). The anionic exchange capacity LDHs allows the controlled release nucleic acids, positioning them promising tools precision therapy. tunable composition enable optimization particle size, charge density, degradation rates to meet specific requirements. At cellular level, taken up via endocytosis, followed by intracellular trafficking, pH‐triggered material. This process protects acids from enzymatic ensures delivery cytoplasm or nucleus. They have successfully encapsulated siRNA effective silencing vitro vivo, downregulating disease‐associated genes conditions cystic fibrosis, muscular dystrophy, chronic viral infections. With their structural versatility, biocompatibility, acid poised revolutionize therapy personalized medicine, providing a safer alternative vectors. review highlights innovative carriers emphasizing structure, versatility targeted

Язык: Английский

Deciphering Convection Enhanced Delivery: A Paradigm Shift for Circumventing Glioblastoma Multiforme

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106398 - 106398

Опубликована: Ноя. 1, 2024

Язык: Английский