A Brief Review on Layered Double Hydroxides (LDH): Innovative Non‐Viral Carriers for Nucleic Acid Delivery

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)

Published: April 1, 2025

Abstract Layered double hydroxides (LDHs) are emerging as versatile, nonviral vectors for gene delivery, offering significant potential in therapeutic applications. Their structure comprises positively charged metal hydroxide layers intercalated with anions, enabling efficient encapsulation of genetic materials like plasmids, small interfering RNA (siRNA), and messenger (mRNA). The anionic exchange capacity LDHs allows the controlled release nucleic acids, positioning them promising tools precision therapy. tunable composition enable optimization particle size, charge density, degradation rates to meet specific requirements. At cellular level, taken up via endocytosis, followed by intracellular trafficking, pH‐triggered material. This process protects acids from enzymatic ensures delivery cytoplasm or nucleus. They have successfully encapsulated siRNA effective silencing vitro vivo, downregulating disease‐associated genes conditions cystic fibrosis, muscular dystrophy, chronic viral infections. With their structural versatility, biocompatibility, acid poised revolutionize therapy personalized medicine, providing a safer alternative vectors. review highlights innovative carriers emphasizing structure, versatility targeted

Language: Английский

Synergizing sustainable green nanotechnology and AI/ML for advanced nanocarriers: A paradigm shift in the treatment of neurodegenerative diseases

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 373 - 397

Published: Nov. 29, 2024

Language: Английский

Deciphering Convection Enhanced Delivery: A Paradigm Shift for Circumventing Glioblastoma Multiforme

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106398 - 106398

Published: Nov. 1, 2024

Language: Английский