Polyphenols and Neurodegenerative Diseases: Potential Effects and Mechanisms of Neuroprotection

Molecules, Год журнала: 2023, Номер 28(14), С. 5415 - 5415

Опубликована: Июль 14, 2023

The increase in people’s longevity has, consequently, led to more brain involvement and neurodegenerative diseases, which can become complicated lead chronic degenerative thereby presenting greater public health problems. Medicinal plants have been used since ancient times contain high concentrations of molecules, including polyphenols. It has proven that polyphenols, are present various natural sources provide curative effects against diseases disorders through neuroprotective effects. These mainly attributed their ability cross the blood–brain barrier, eliminate reactive oxygen species, cause chelation metal ions. Polyphenols concentration neurotrophic factors bind directly membrane receptors these factors, modulate activate signaling cascades allow plasticity, survival, proliferation, growth neuronal cells, allowing for better learning, memory, cognition. Moreover, polyphenols no serious adverse side resulting from consumption.

Язык: Английский

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Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS

Heliyon, Год журнала: 2021, Номер 7(5), С. e06986 - e06986

Опубликована: Май 1, 2021

In order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water (WESB) Shaggy bindweed (Convulvulus betonicifolia Mill. Subs), some putative methods such as DPPH· scavenging activity, ABTS•+ effect, ferric ions (Fe3+) reduction method, cupric (Cu2+) reducing capacity, ferrous (Fe2+) binding activities were separately performed. Also, ascorbic acid, α-tocopherol BHT used standard compounds. Additionally, phenolic compounds that responsible for abilities EESB WESB screened by liquid chromatography-high resolution mass spectrometry (LC-HRMS). At same concentration, demonstrated effective when compared standards. addition, IC50 values 1.946 μg/mL against acetylcholinesterase (AChE), 0.815 α-glycosidase 0.675 α-amylase enzymes.

Язык: Английский

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Phenolic Bioactives From Plant-Based Foods for Glycemic Control

Frontiers in Endocrinology, Год журнала: 2022, Номер 12

Опубликована: Янв. 18, 2022

Plant-based foods containing phenolic bioactives have human health protective functions relevant for combating diet and lifestyle-influenced chronic diseases, including type 2 diabetes (T2D). The molecular structural features of dietary allow antioxidant countering oxidative stress-induced metabolic breakdown commonly associated with T2D. In addition to properties, diverse plant therapeutic functional activities such as improving insulin sensitivity, reducing hepatic glucose output, inhibiting activity key carbohydrate digestive enzymes, modulating absorption in the bloodstream, thereby subsequently post-prandial glycemic control. These properties direct implications benefits management Therefore, plant-based that are rich excellent sources targets improve overall control by managing hyperglycemia stress, which major contributing factors T2D pathogenesis. However, studies array foods, concentration composition their bioactivity can vary widely between different species, parts, among varieties/genotypes due environmental growing conditions, post-harvest storage, food processing steps. This has allowed advances innovative strategies screen optimize whole processed derived ingredients based on bioactive linked anti-hyperglycemic effective integration into focused solutions. this review, pre-harvest influence bioactive-linked derivation extracts potential highlighted discussed. Additionally, novel bioprocessing enhance bioavailability phenolics plant-derived targeting optimum also advanced.

Язык: Английский

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Phytochemical profile and antioxidant capacity, α-amylase and α-glucosidase inhibitory activities of Oxalis pes-caprae extracts in alloxan-induced diabetic mice

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 160, С. 114393 - 114393

Опубликована: Фев. 10, 2023

Diabetes and its complications are closely correlated with chronic hyperglycemia, causing severe oxidative stress leading to glycation reaction formation of advanced end products. However, medicinal plants still a source inspiration for the discovery new treatments several diseases, including diabetes. The present study was aimed evaluate antioxidant antidiabetic properties Oxalis pes-caprae flowers extract in alloxan-induced diabetic mice. phytochemical activities both aqueous methanolic extracts were assessed by in-vitro testing such as free radical scavenging assays (DPPH ABTS+), ferrous ions (Fe2+) chelating activity reducing power assay. Additionally, detection Amadori products used determine antiglycation potential. α-glucosidase α-amylase inhibitory assessment employed effect, while mice measure in-vivo antioxidants carbohydrates enzymes. effect on body weight blood glucose level extract-treated also investigated. Among tested extract, richest phenolic compounds which is directly related their remarkable antioxidant, enzyme activity. oral administration two doses (150 mg/kg 250 mg/kg) daily 3 weeks resulted hypoglycemic compared reference drug, glibenclamide (10 mg/kg). Furthermore, shown significantly increase glycolysis enzymes liver, kidney spleen mice, control group. Therefore, effectively exhibited effects indicated studies, confirming protective hyperglycemia damage.

Язык: Английский

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Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies

Current Topics in Medicinal Chemistry, Год журнала: 2023, Номер 23(8), С. 589 - 617

Опубликована: Янв. 9, 2023

Abstract: A sedentary lifestyle has evoked a high risk of cardiovascular (CV) disease, diabetes, and obesity, all them with morbimortality rates common denominator, hypertension. Numerous pharmacological drugs have been used for the treatment However, side effects associated use existing therapies triggered demand plant-based medications. In this connection, aim review was to provide an in-depth analysis plant-derived bioactives effective management Phyto-constituents from leaves, bark, stem, roots, seeds, fruits medicinal plants grown in our differ-ent regions globe highly searched. Among them, polyphenols (e.g., flavonoids as quercetin, anthocyanins cyanidin, tannins ellagic acid, stilbenes resveratrol, lignans honokiol others hydroxytyrosol or curcumin), organosulfur compounds (e.g. s-allyl cysteine allicin), fatty acids α-lipoic DHA oleic acid), alkaloids berberine tetran-drine) some terpenes intensively investigated hypertension, ability being stated controlling blood pressure related health problems both vivo vitro studies. Some activities presented by these bioactive are reducing oxidative stress, renin-angiotensin system control, SIRT1 activation, regulating platelet aggregation COX activity, anti-atherogenic effects, anti-inflammatory properties, vasorelaxa-tion other results that translate into prevention control The knowledge is important developing countries where traditional medicine majority, but it can also give rise new approaches hypertension therapy.

Язык: Английский

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Growth years and post-harvest processing methods have critical roles on the contents of medicinal active ingredients of Scutellaria baicalensis

Industrial Crops and Products, Год журнала: 2020, Номер 158, С. 112985 - 112985

Опубликована: Ноя. 1, 2020

Язык: Английский

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Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

Frontiers in Pharmacology, Год журнала: 2020, Номер 11

Опубликована: Апрель 8, 2020

Atherosclerosis is a chronic multifactorial disease characterized by mainly changes of blood lipids profile and inflammation in vessel wall. The cardiovascular based on atherosclerosis currently the leading cause mortality developed countries. Therefore timely prevention therapy are able to reduce risk development its clinical manifestations. Anti-atherosclerotic activity medicinal plants appears their multiple effects such as anti-inflammatory, antioxidant, anti-atherogenic, hypotensive, lipid-lowering, anti-thrombotic. Moreover, most pleiotropic anti-atherosclerotic action. In addition, plants-derived pharmacological substances and/or compounds relative safety fewer side that allows considering them one potential effective agents. direct effect some was confirmed trials carotid IMT progression during long-term medication with plants. This review attempted determine current status databases PubMed Scopus (until November, 2019) investigate possessing experimental studies.

Язык: Английский

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LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

Molecules, Год журнала: 2021, Номер 26(9), С. 2469 - 2469

Опубликована: Апрель 23, 2021

Kınkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on biological activities chemical composition of this plant. In study, phytochemical composition; metabolic enzyme inhibition; antidiabetic, anticholinergic, antioxidant were assessed. order to evaluate activity evaporated ethanolic extract (EEFS) lyophilized water (WEFS) kınkor stellata), putative methods such DPPH· scavenging activity, ABTS•+ ferric ions (Fe3+) reduction method, cupric (Cu2+) reducing capacity, ferrous (Fe2+)-binding separately performed. Furthermore, ascorbic acid, BHT, α-tocopherol standard compounds. Additionally, main phenolic compounds that responsible for abilities ethanol extracts determined by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol demonstrated effective when compared standards. Moreover, IC50 values 1.772 μg/mL acetylcholinesterase (AChE), 33.56 ± 2.96 α-glycosidase, 0.639 α-amylase respectively.

Язык: Английский

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Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa

Bulletin of the National Research Centre/Bulletin of the National Research Center, Год журнала: 2021, Номер 45(1)

Опубликована: Окт. 21, 2021

Abstract Background Withania somnifera (L.) Dunal ( W. ) is a herb commonly known by its English name as Winter Cherry. Africa indigenous to many medicinal plants and natural products. However, there inadequate documentation of plants, including , in Africa. There is, therefore, need for comprehensive compilation research outcomes this reviewed plant used traditional medicine different regions Methodology Scientific articles publications were scooped sourced from high-impact factor journals filtered with relevant keywords on . databases, GBIF, PubMed, NCBI, Google Scholar, Research Gate, Science Direct, SciFinder, Web Science, accessed identify the most influential recent breakthroughs published contexts ethnography, ethnomedicinal uses, phytochemistry, pharmacology, commercialization Results This critical review covers usage demonstrate use elsewhere prevent or alleviate several pathophysiological conditions, cardiovascular, neurodegenerative, reproductive impotence, well other chronic diseases. Conclusion reportedly safe administration ethnomedicine confirmed safety status. The significance commercializing drug development herein thoroughly covered provide much-needed highlights towards cultivations economic benefit

Язык: Английский

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Efficacy and Safety of Mulberry Twig Alkaloids Tablet for the Treatment of Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy, and Parallel Controlled Clinical Trial

Diabetes Care, Год журнала: 2021, Номер 44(6), С. 1324 - 1333

Опубликована: Апрель 8, 2021

OBJECTIVE This study aimed to evaluate the efficacy and safety of mulberry twig alkaloids (Sangzhi [SZ-A]) in treatment type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS was a multicenter, randomized, double-blind, double-dummy, parallel controlled noninferiority clinical trial that conducted for 24 weeks. A total 600 patients were randomly allocated SZ-A group (n = 360) or acarbose 240). The primary end point change glycosylated hemoglobin (HbA1c) compared with baseline. In addition, adverse events (AEs), severe AEs (SAEs), treatment-related (TAEs), gastrointestinal disorders (GDs) monitored. RESULTS After weeks, HbA1c –0.93% (95% CI –1.03 –0.83) (–10.2 mmol/mol [–11.3 –9.1]) –0.87% (–0.99 –0.76) (–9.5 [–10.8 –8.3]) groups, respectively, least squares mean difference –0.05% –0.18 0.07) (–0.5 [–2.0 0.8]) between two no significant on basis covariance analysis (P > 0.05). incidence TAEs GDs significantly lower than < 0.01), but differences SAEs groups observed CONCLUSIONS exhibited equivalent hypoglycemic effects T2D. Nevertheless, following treatment, suggesting good safety.

Язык: Английский

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