Evidence-based Complementary and Alternative Medicine,
Год журнала:
2022,
Номер
2022, С. 1 - 11
Опубликована: Июль 30, 2022
The
lower
respiratory
tract
infection,
induced
by
influenza
virus,
coronaviruses,
and
syncytial
remains
a
serious
threat
to
human
health
that
can
cause
global
pandemic.
Thus,
finding
effective
chemicals
therapeutic
measures
advance
the
functional
restoration
of
after
infection
has
been
emphasis
studies
on
subjects.
Mosla
scabra
is
natural
medicinal
plant
used
for
treating
various
lung
gastrointestinal
diseases,
including
viral
cough,
chronic
obstructive
pulmonary
disease,
acute
gastroenteritis,
diarrhoea.
In
this
study,
antiviral
anti-inflammatory
effects
total
lignans
(MSTL)
extracted
from
were
investigated
in
A
virus
(IAV)-infected
mice
RAW
264.7
macrophages.
MSTL
could
not
only
protect
macrophages
against
IAV-induced
pyroptosis
but
also
lighten
inflammation
IAV
vivo
vitro.
network
pharmacology
analysis
revealed
differentially
expressed
genes,
mainly
involving
EGFR
tyrosine
kinase
inhibitor
resistance,
endocrine
HIF-1
signaling
pathway,
C-type
lectin
receptor
FOXO
contributed
alveolar
macrophage
dysfunction.
It
indicated
enhanced
function
improved
injury
mice.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 23, 2024
Traditional
Chinese
medicine
(TCM)
is
the
practical
experience
and
summary
of
nation
for
thousands
years.
It
shows
great
potential
in
treating
various
chronic
diseases,
complex
diseases
major
infectious
has
gradually
attracted
attention
people
all
over
world.
However,
due
to
complexity
prescription
action
mechanism
TCM,
development
TCM
industry
still
a
relatively
conservative
stage.
With
rise
artificial
intelligence
technology
fields,
many
scholars
began
apply
traditional
made
remarkable
progress.
This
paper
comprehensively
summarizes
important
role
from
aspects,
including
new
drug
discovery,
data
mining,
quality
standardization
medicine.
The
limitations
these
applications
are
also
emphasized,
lack
pharmacological
research,
database
problems
challenges
brought
by
human-computer
interaction.
Nevertheless,
opportunities
innovations
modernization
Integrating
into
comprehensive
application
expected
overcome
faced
further
promote
whole
industry.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Апрель 28, 2022
The
effect
of
a
drug
on
the
intestinal
flora
and
barrier
is
an
important
evaluation
index
for
safety
efficacy.
Chemical
synthetic
drugs
are
widely
used
due
to
their
advantages
fast
efficacy
low
doses,
but
they
prone
cause
resistance
inhibit
proton
pumps,
which
may
harm
health.
Traditional
Chinese
medicine
(TCM)
has
been
applied
clinically
thousands
years,
how
TCMs
regulate
health
achieve
effects
disease
treatment
become
hot
research
topic
that
needs
be
resolved.
This
paper
reviews
recent
microorganisms
mucosal
after
entering
intestine,
discusses
interaction
mechanisms
between
flora,
details
repair
provide
reference
development,
utilization,
modernization
TCM.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Март 10, 2022
Fuzi
is
a
famous
toxic
traditional
herbal
medicine,
which
has
long
been
used
for
the
treatment
of
various
diseases
in
China
and
many
other
Asian
countries
because
its
extraordinary
pharmacological
activities
high
toxicity.
Different
processing
methods
to
attenuate
toxicity
are
important
safe
clinical
use.
In
this
study,
desorption
electrospray
ionization
mass
spectrometry
imaging
(DESI-MSI)
with
metabolomics-combined
multivariate
statistical
analysis
approach
was
applied
investigate
series
Aconitum
alkaloids
explore
potential
metabolic
markers
understand
differences
between
raw
processed
different
steaming
time
points.
Moreover,
selected
were
visualized
by
DESI-MSI,
six
index
alkaloids'
contents
determined
through
HPLC.
The
results
indicated
visible
among
times,
4.0
h
proper
attenuation
efficacy
reservation.
A
total
42
identified
discriminate
those
steamed
8.0
h,
clearly
DESI-MSI.
transformation
from
diester-diterpenoid
monoester-diterpenoid
then
non-esterified
diterpene
hydrolysis
major
process
during
steaming.
DESI-MSI
combined
metabolomics
provides
an
efficient
method
visualize
changeable
rules
screen
wide
application
technique
could
help
identify
reveal
possible
chemical
transition
mechanism
"Paozhi"
processes
Fuzi.
It
also
easy
way
quality
control
ensures
safety
Chinese
medicine.
Journal of Pharmaceutical Analysis,
Год журнала:
2023,
Номер
13(12), С. 1496 - 1509
Опубликована: Авг. 17, 2023
Diabetes
cardiomyopathy
(DCM)
is
a
metabolic
disease
and
leading
cause
of
heart
failure
among
people
with
diabetes.
Mass
spectrometry
imaging
(MSI)
versatile
technique
capable
combining
the
molecular
specificity
mass
spatial
information
imaging.
In
this
study,
we
used
MSI
to
visualize
metabolites
in
rat
high
resolution
sensitivity.
We
optimized
air
flow-assisted
desorption
electrospray
ionization
(AFADESI)-MSI
platform
detect
wide
range
metabolites,
then
matrix-assisted
laser
(MALDI)-MSI
for
increasing
coverage
improving
localization
resolution.
AFADESI-MSI
detected
214
149
positive
negative
analyses
sections,
respectively,
while
MALDI-MSI
61
analysis.
Our
study
revealed
heterogenous
profile
DCM
model,
over
105
region-specific
changes
levels
metabolite
classes,
including
carbohydrates,
amino
acids,
nucleotides,
their
derivatives,
fatty
glycerol
phospholipids,
carnitines,
metal
ions.
The
repeated
oral
administration
ferulic
acid
during
20
weeks
significantly
improved
most
disorders
model.
findings
provide
novel
insights
into
mechanisms
underlying
potential
as
therapeutic
agent
treating
condition.
Food Chemistry X,
Год журнала:
2023,
Номер
19, С. 100860 - 100860
Опубликована: Сен. 3, 2023
The
quality
and
safety
of
edible
crops
are
key
links
inseparable
from
human
health
nutrition.
In
the
era
rapid
development
artificial
intelligence,
using
it
to
mine
multi-source
information
on
provides
new
opportunities
for
industrial
market
supervision
crops.
This
review
comprehensively
summarized
applications
data
combined
with
machine
learning
in
evaluation
Multi-source
can
provide
more
comprehensive
rich
a
single
source,
as
integrate
different
information.
Supervised
unsupervised
is
applied
analysis
achieve
requirements
Emphasized
advantages
disadvantages
techniques
methods,
problems
that
need
be
overcome,
promising
directions
were
proposed.
To
monitor
real-time,
methods
must
innovated.
Acta Pharmacologica Sinica,
Год журнала:
2022,
Номер
43(12), С. 3096 - 3111
Опубликована: Окт. 13, 2022
Natural
products
(NPs)
and
their
structural
analogs
represent
a
major
source
of
novel
drug
development
for
disease
prevention
treatment.
The
new
drugs
from
NPs
includes
two
crucial
aspects.
One
is
the
discovery
medicinal
plants/microorganisms,
other
evaluation
in
vivo
at
various
physiological
pathological
states.
heterogeneous
spatial
distribution
plants/microorganisms
or
can
provide
valuable
information
development.
However,
few
molecular
imaging
technologies
detect
thousands
compounds
simultaneously
on
label-free
basis.
Over
last
decades,
mass
spectrometry
(MSI)
methods
have
progressively
improved
diversified,
thereby
allowing
applications
NP
research.
Because
MSI
allows
mapping
production
numerous
molecules
situ
without
labeling,
it
provides
visualization
tool
Therefore,
we
focused
this
mini-review
summarizing
technology
discovering
plants
evaluating
preclinical
studies
perspective
research
(R&D).
Additionally,
briefly
reviewed
factors
that
should
be
carefully
considered
to
obtain
desired
results.
Finally,
future
R&D
proposed.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 31, 2025
Spatial
metabolomics
is
an
emerging
technology
that
integrates
mass
spectrometry
imaging
(MSI)
with
metabolomics,
offering
a
novel
visual
perspective
for
traditional
analysis.
This
enables
in-depth
analysis
in
three
dimensions:
qualitative,
quantitative,
and
localization
of
metabolites.
precisely
reflects
the
characteristics
metabolic
network
changes
metabolites
within
entire
tissues
or
specific
micro-regions.
It
provides
detailed
understanding
pharmacodynamic
material
basis
mechanisms
action.
These
capabilities
suggest
spatial
can
offer
significant
technical
support
studying
complex
pathophysiology
mental
disorders.
Although
underlying
disorders
have
been
reviewed
multiple
times,
this
paper
comprehensive
comparison
between
metabolomics.
also
summarizes
latest
progress
challenges
applying
to
study
Chinese
medicine.
Frontiers in Plant Science,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 21, 2025
Ziziphi
Spinosae
Semen
(ZSS),
a
medicinal
food,
is
one
of
the
most
popular
Chinese
herbs,
known
for
its
rich
bioactive
ingredients,
such
as
terpenoids
and
flavonoids.
The
content
these
ingredients
in
ZSS
varies
with
age.
However,
distribution
throughout
developmental
phases
ZSS-white
maturity
(S1),
firm
ripening
(S2),
full
(S3)-and
within
specific
tissues
like
cotyledon,
endosperm,
radicle,
has
not
yet
been
determined.
This
research
aimed
to
analyze
spatial
key
quality
markers
elucidate
metabolite
characteristics
growth
stages.
Utilizing
matrix-assisted
laser
desorption/ionization-mass
spectrometry
imaging
(MALDI-MSI),
25
were
identified
visualized
ZSS,
including
three
terpenoids,
seven
flavonoids,
four
alkaloids,
eleven
amino
acids.
MALDI
images
revealed
distinct
variations
across
different
regions
Moreover,
matured,
area
significantly
increased,
encompassing
six
two
ion
imagery,
Principal
Component
Analysis
(PCA)
coupled
Orthogonal
Partial
Least
Squares
Discriminant
(OPLS-DA)
effectively
differentiated
samples
from
various
periods.
Additionally,
nine
major
potential
ZSS.
demonstrates
that
components
change
during
growth.
analysis
provided
by
MALDI-MSI
offers
an
experimental
basis
understanding
accumulation
maturation
