Synergistic antidepressant-like effects of biotics and n-3 polyunsaturated fatty acids on dopaminergic pathway through the brain-gut axis in rats exposed to chronic mild stress DOI Creative Commons
Hyunji Cho, Yongsoon Park

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 29, 2024

Abstract Probiotics, postbiotics, and n-3 polyunsaturated fatty acids (PUFA) have antidepressant-like effects. However, the underlying mechanisms of dopaminergic pathway are unclear. The present study investigated hypothesis that probiotics postbiotics combined with PUFA synergistically improve depression by modulating through brain-gut axis. Rats were randomly divided into seven groups: non-chronic mild stress (CMS) n-6 PUFA, CMS probiotics, PUFA. improved depressive behaviors, decreased blood concentrations corticosterone, interferon-γ, interleukin-1β, increased brain gut short chain dopamine. Moreover, expression glucocorticoid receptor, tyrosine hydroxylase, occludin; l-type amino acid transporter 1 dopamine receptor (DR) D1; DRD2. phosphorylated protein kinase A/protein A cAMP response element-binding protein/cAMP in brain, however, supplementation There was synergistic effect on behaviors blood, gut. no significant difference pathways between observed. In conclusion, effects axis rats exposed to CMS.

Язык: Английский

Gut microbiome and frailty: insight from genetic correlation and mendelian randomization DOI Creative Commons
Guanghui Cui, Shaojie Li, Hui Ye

и другие.

Gut Microbes, Год журнала: 2023, Номер 15(2)

Опубликована: Ноя. 21, 2023

Observational studies have shown that the gut microbiome is associated with frailty. However, whether these associations underlie causal effects remains unknown. Thus, this study aimed to assess genetic correlation and relationships between genetically predicted frailty using linkage disequilibrium score regression (LDSC) Mendelian Randomization (MR). Summary statistics for were obtained from a genome-wide association (GWAS) meta-analysis of MiBioGen consortium (N = 18,340). GWAS meta-analysis, including UK Biobank TwinGene 175,226). We used LDSC MR analyses estimate causality Our findings indicate suggestive Christensenellaceae R-7 Moreover, we found evidence twelve genus-level microbes on at least two methods. There was no horizontal pleiotropy or heterogeneity in analysis. This provides potential several More population-based observational animal experiments are required clarify underlying mechanisms.

Язык: Английский

Процитировано

27
Mechanisms for the biological activity of Gastrodia elata Blume and its constituents: A comprehensive review on sedative-hypnotic, and antidepressant properties DOI
Haibo Zhou,

Sheng-ze Lu,

Zhong-shun Yu

и другие.

Phytomedicine, Год журнала: 2023, Номер 123, С. 155251 - 155251

Опубликована: Ноя. 28, 2023

Язык: Английский

Процитировано

22
Repeated ( S )-ketamine administration ameliorates the spatial working memory impairment in mice with chronic pain: role of the gut microbiota–brain axis DOI Creative Commons

Yubin Jiang,

Xingming Wang,

Jiawei Chen

и другие.

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 8, 2024

Chronic pain is commonly linked with diminished working memory. This study explores the impact of anesthetic (S)-ketamine on spatial memory in a chronic constriction injury (CCI) mouse model, focusing gut microbiome. We found that multiple doses (S)-ketamine, unlike single dose, counteracted reduced spontaneous alteration percentage (%SA) Y-maze test, without affecting mechanical or thermal sensitivity. Additionally, repeated treatments improved abnormal composition microbiome (β-diversity), as indicated by fecal 16S rRNA analysis, and increased levels butyrate, key – brain axis mediator. Protein analysis showed these also corrected upregulated histone deacetylase 2 (HDAC2) downregulated brain-derived neurotrophic factor (BDNF) hippocampi CCI mice. Remarkably, microbiota transplantation from mice treated repeatedly to restored %SA hippocampal BDNF Butyrate supplementation alone %SA, BDNF, HDAC2 Furthermore, TrkB receptor antagonist ANA-12 negated beneficial effects impairment These results indicate administration ameliorates mice, mediated axis, primarily through enhancement signaling butyrate.

Язык: Английский

Процитировано

9
The role of symbiotic fungi in the life cycle of Gastrodia elata Blume (Orchidaceae): a comprehensive review DOI Creative Commons
Jiajia Liu,

Xiaoqi Yang,

Haiyang Yu

и другие.

Frontiers in Plant Science, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

Blume, a fully mycoheterotrophic perennial plant of the family Orchidaceae, is traditional Chinese herb with medicinal and edible value. Interestingly,

Язык: Английский

Процитировано

8
TCM “medicine and food homology” in the management of post-COVID disorders DOI Creative Commons
C. Y. Ng,

H. Bun,

Yan Zhao

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Авг. 31, 2023

The World Health Organization declared that COVID-19 is no longer a public health emergency of global concern on May 5, 2023. Post-COVID disorders are, however, becoming more common. Hence, there lies growing need to develop safe and effective treatment measures manage post-COVID disorders. Investigating the use TCM medicinal foods in long-term therapy illnesses may be beneficial given contemporary research's emphasis development foods.The for highlighted this review. Following discussion history "Medicine Food Homology" theory, pathophysiological effects will briefly reviewed. An analysis their functions treating then provided before offering some insight into potential directions future research application.TCM can different aspects management efficient choice because they are typically milder nature than chronic drug use. These findings also applied post-disease similar respiratory

Язык: Английский

Процитировано

13
Whey protein isolate attenuates depression-like behavior developed in a mouse model of breast tumor DOI
Shufang Xia, Gusonghan Maitiniyazi, Yuan Liu

и другие.

Food Research International, Год журнала: 2023, Номер 169, С. 112849 - 112849

Опубликована: Апрель 18, 2023

Язык: Английский

Процитировано

11
Discovery of seed germinating fungi (Mycetinis scorodonius) from Gastrodia elata Bl. f. glauca S. chow in Changbai Mountain and examination of their germination ability DOI Creative Commons
Xinyu Yang, Yugang Gao, Zhaochun Li

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 28, 2024

Abstract Multi-generational asexual reproduction of Gastrodia elata Bl. will cause seedling species degeneration. Sexual seed is an effective method to solve the problem The development seeds cannot be separated from germination fungus. However, there are few strains fungus in production, and also degradation application for many years. It very important sexual isolate more new excellent origin. This study used f. glauca S. chow vegetative propagation corms capture its symbiotic fungus, comprehensively identified by colony morphology, ITS, sporocarps regeneration function, compared growth characteristics ability with other ( Mycena purpureofusca , dendrobii osmundicola ). was isolated named GYGL-1. After comprehensive identification, GYGL-1 Mycetinis scorodonius . Compared has fast speed, vigorous growth, high seeds. Innovated isolation obtained regenerated discovered that a function germinating seeds, enriching resource library

Язык: Английский

Процитировано

4
Amino acid metabolites profiling in unpredictable chronic mild stress-induced depressive rats and the protective effects of Gastrodia elata Blume and Gastrodin DOI

Crystal Ngofi Zumbi,

Hailey Hei Tung Choi,

Huai‐Syuan Huang

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 337, С. 118906 - 118906

Опубликована: Окт. 11, 2024

Язык: Английский

Процитировано

4
Antidepressant effect of carvedilol on streptozotocin-induced diabetic peripheral neuropathy mice by altering gut microbiota DOI
Weifeng Wu, Chao Zeng,

Caineng Wu

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 730, С. 150374 - 150374

Опубликована: Июль 9, 2024

Язык: Английский

Процитировано

3
Synbiotic yacon juice fermented by Lactiplantibacillus plantarum QS7T attenuates dextran sodium sulfate‐induced ulcerative colitis in mice DOI Open Access
Gu Gong, Rui Li,

Shuang Cui

и другие.

Journal of Food Science, Год журнала: 2025, Номер 90(3)

Опубликована: Март 1, 2025

ABSTRACT Ulcerative colitis (UC) is a prevalent inflammatory bowel disease associated with abnormal immune responses to commensal bacteria. The study investigated the effects of synbiotic yacon juice fermented by Lactiplantibacillus plantarum QS7T (FYJ) on ameliorating UC and modulating gut microbiota in dextran sodium sulfate (DSS)‐induced mouse model. FYJ intervention significantly improved body weight colon length, reduced activity index histopathological scores, effectively alleviated tissue damage compared treatments L. suspension or alone. Additionally, DSS‐induced led significant decrease occludin mRNA expression an upregulation genes encoding pro‐inflammatory cytokines, which were normalized treatment. These accompanied inhibition TLR4/MyD88/NF‐κB signaling pathway. Moreover, treatment reversed alternations community beta diversity composition. In conclusion, could reduce intestinal mucosal inflammation, repair colonic mucosa, improve physiological status mice, possibly through regulation pathway Practical Application restores imbalance thereby preserving immunity barrier integrity. insights derived from this are expected provide novel perspective potential application as functional food agent for treating UC.

Язык: Английский

Процитировано

0