All Life,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: July 4, 2024
The
present
study
investigated
the
effect
of
Gastrodia
elata
extracts
(GE)
on
chronic
electric
foot-shock
stress
(cEFS)-induce
anxiety-like
behaviors
in
male
C57BL/6
mice.
Mice
were
administered
GE
(200
or
400
mg/kg/day,
oral),
and
then
exposed
to
cEFS
(0.6
mA
intensity,
1
s
every
5
interval,
3
min
duration)
for
seven
days.
treatment
ameliorates
behavior
induced
by
cEFS,
which
determined
with
elevated
plus
maze
test
open
field
test.
decreased
dopamine
serotonin
levels
brain
both
reversed
treatment.
increased
corticosterone
serum
number
c-fos
positive
cells
brain,
downregulated
These
results
suggested
that
regulating
serotonin,
serum.
Gut Microbes,
Journal Year:
2023,
Volume and Issue:
15(2)
Published: Nov. 21, 2023
Observational
studies
have
shown
that
the
gut
microbiome
is
associated
with
frailty.
However,
whether
these
associations
underlie
causal
effects
remains
unknown.
Thus,
this
study
aimed
to
assess
genetic
correlation
and
relationships
between
genetically
predicted
frailty
using
linkage
disequilibrium
score
regression
(LDSC)
Mendelian
Randomization
(MR).
Summary
statistics
for
were
obtained
from
a
genome-wide
association
(GWAS)
meta-analysis
of
MiBioGen
consortium
(N
=
18,340).
GWAS
meta-analysis,
including
UK
Biobank
TwinGene
175,226).
We
used
LDSC
MR
analyses
estimate
causality
Our
findings
indicate
suggestive
Christensenellaceae
R-7
Moreover,
we
found
evidence
twelve
genus-level
microbes
on
at
least
two
methods.
There
was
no
horizontal
pleiotropy
or
heterogeneity
in
analysis.
This
provides
potential
several
More
population-based
observational
animal
experiments
are
required
clarify
underlying
mechanisms.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 8, 2024
Chronic
pain
is
commonly
linked
with
diminished
working
memory.
This
study
explores
the
impact
of
anesthetic
(S)-ketamine
on
spatial
memory
in
a
chronic
constriction
injury
(CCI)
mouse
model,
focusing
gut
microbiome.
We
found
that
multiple
doses
(S)-ketamine,
unlike
single
dose,
counteracted
reduced
spontaneous
alteration
percentage
(%SA)
Y-maze
test,
without
affecting
mechanical
or
thermal
sensitivity.
Additionally,
repeated
treatments
improved
abnormal
composition
microbiome
(β-diversity),
as
indicated
by
fecal
16S
rRNA
analysis,
and
increased
levels
butyrate,
key
–
brain
axis
mediator.
Protein
analysis
showed
these
also
corrected
upregulated
histone
deacetylase
2
(HDAC2)
downregulated
brain-derived
neurotrophic
factor
(BDNF)
hippocampi
CCI
mice.
Remarkably,
microbiota
transplantation
from
mice
treated
repeatedly
to
restored
%SA
hippocampal
BDNF
Butyrate
supplementation
alone
%SA,
BDNF,
HDAC2
Furthermore,
TrkB
receptor
antagonist
ANA-12
negated
beneficial
effects
impairment
These
results
indicate
administration
ameliorates
mice,
mediated
axis,
primarily
through
enhancement
signaling
butyrate.
Frontiers in Plant Science,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 8, 2024
Blume,
a
fully
mycoheterotrophic
perennial
plant
of
the
family
Orchidaceae,
is
traditional
Chinese
herb
with
medicinal
and
edible
value.
Interestingly,
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 31, 2023
The
World
Health
Organization
declared
that
COVID-19
is
no
longer
a
public
health
emergency
of
global
concern
on
May
5,
2023.
Post-COVID
disorders
are,
however,
becoming
more
common.
Hence,
there
lies
growing
need
to
develop
safe
and
effective
treatment
measures
manage
post-COVID
disorders.
Investigating
the
use
TCM
medicinal
foods
in
long-term
therapy
illnesses
may
be
beneficial
given
contemporary
research's
emphasis
development
foods.The
for
highlighted
this
review.
Following
discussion
history
"Medicine
Food
Homology"
theory,
pathophysiological
effects
will
briefly
reviewed.
An
analysis
their
functions
treating
then
provided
before
offering
some
insight
into
potential
directions
future
research
application.TCM
can
different
aspects
management
efficient
choice
because
they
are
typically
milder
nature
than
chronic
drug
use.
These
findings
also
applied
post-disease
similar
respiratory
Journal of Food Science,
Journal Year:
2025,
Volume and Issue:
90(3)
Published: March 1, 2025
ABSTRACT
Ulcerative
colitis
(UC)
is
a
prevalent
inflammatory
bowel
disease
associated
with
abnormal
immune
responses
to
commensal
bacteria.
The
study
investigated
the
effects
of
synbiotic
yacon
juice
fermented
by
Lactiplantibacillus
plantarum
QS7T
(FYJ)
on
ameliorating
UC
and
modulating
gut
microbiota
in
dextran
sodium
sulfate
(DSS)‐induced
mouse
model.
FYJ
intervention
significantly
improved
body
weight
colon
length,
reduced
activity
index
histopathological
scores,
effectively
alleviated
tissue
damage
compared
treatments
L.
suspension
or
alone.
Additionally,
DSS‐induced
led
significant
decrease
occludin
mRNA
expression
an
upregulation
genes
encoding
pro‐inflammatory
cytokines,
which
were
normalized
treatment.
These
accompanied
inhibition
TLR4/MyD88/NF‐κB
signaling
pathway.
Moreover,
treatment
reversed
alternations
community
beta
diversity
composition.
In
conclusion,
could
reduce
intestinal
mucosal
inflammation,
repair
colonic
mucosa,
improve
physiological
status
mice,
possibly
through
regulation
pathway
Practical
Application
restores
imbalance
thereby
preserving
immunity
barrier
integrity.
insights
derived
from
this
are
expected
provide
novel
perspective
potential
application
as
functional
food
agent
for
treating
UC.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 29, 2025
Microorganisms
are
one
of
the
most
promising
biomarkers
for
cancer,
and
relationship
between
microorganisms
lung
cancer
occurrence
development
provides
significant
potential
pulmonary
nodule
(PN)
diagnosis
from
a
microbiological
perspective.
This
study
aimed
to
analyze
salivary
microbiota
features
patients
with
PN
assess
as
non-invasive
biomarker.
We
collected
saliva
smples
153
40
controls.
Using
16
S
rRNA
gene
sequencing,
differences
in
α-
β-diversity
community
composition
group
controls
were
analyzed.
Subsequently,
specific
microbial
variables
selected
using
six
models
trained
on
features.
The
evaluated
metrics,
such
area
under
receiver
operating
characteristic
curve
(AUC),
identify
best-performing
model.
Furthermore,
Bayesian
optimization
algorithm
was
used
optimize
this
Finally,
SHapley
Additive
exPlanations
(SHAP)
interpretability
framework
interpret
output
optimal
model
biomarkers.
Significant
observed
Although
predominant
genera
consistent
groups,
disparities
their
relative
abundances.
By
leveraging
random
forest
algorithm,
ten
identified
incorporated
into
models,
which
effectively
facilitated
diagnosis.
XGBoost
demonstrated
best
performance.
Further
resulted
Optimization-based
(BOXGB)
Based
BOXGB
model,
an
online
microbiota-based
prediction
platform
developed.
Lastly,
SHAP
analysis
suggested
Defluviitaleaceae_UCG-011,
Aggregatibacter,
Oribacterium,
Bacillus,
Prevotalla
proved
biomarker,
expanding
clinical
diagnostic
approaches
PN.
Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107730 - 107730
Published: April 1, 2025
This
review
examines
the
multifaceted
roles
of
medicinal
plant
natural
products
in
influencing
gut
microbiota
and
their
subsequent
impact
on
various
organ
systems
through
established
axes,
including
gut-brain,
gut-liver,
gut-heart,
gut-lung,
gut-kidney
axes.
Medicinal
have
exhibited
diverse
pharmacological
activities,
modulation
composition,
enhancement
metabolic
processes,
alleviation
inflammation
oxidative
stress.
Evidence
suggests
that
these
components
can
ameliorate
conditions
such
as
neurological
disorders,
syndrome,
chronic
kidney
disease
by
restoring
microbial
balance
improving
barrier
integrity.
Furthermore,
highlights
potential
to
foster
beneficial
communities
improve
health,
which
may
lead
reduced
severity
inflammation.
By
comprehensively
analyzing
current
literature,
this
provides
a
foundation
for
future
research
aim
at
exploring
therapeutic
applications
prevention
treatment.
The
findings
underscore
need
further
studies
elucidate
underlying
mechanisms
action
validate
clinical
efficacy
managing
modulation.
