Effects of scutellarin on the mechanism of cardiovascular diseases: a review
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
Cardiovascular
diseases
represent
a
significant
worldwide
problem,
jeopardizing
individuals’
physical
and
mental
wellbeing
as
well
their
quality
of
life
result
widespread
incidence
fatality.
With
the
aging
society,
occurrence
is
progressively
rising
each
year.
However,
although
drugs
developed
for
treating
have
clear
targets
proven
efficacy,
they
still
carry
certain
toxic
side
effect
risks.
Therefore,
finding
safe,
effective,
practical
treatment
options
crucial.
Scutellarin
primary
constituent
Erigeron
breviscapus
(Vant.)
Hand-Mazz.
This
article
aims
to
establish
theoretical
foundation
creation
use
secure,
productive,
logical
medications
in
curing
heart-related
illnesses.
Additionally,
examination
analysis
signal
pathway
its
associated
mechanisms
with
regard
employment
SCU
heart
will
impart
innovative
resolving
concepts
prevention
diseases.
Язык: Английский
Comparative pharmacokinetic study on phenolic acids and flavonoids in normal and microcirculation dysfunction rats plasma by UPLC-TQ/MS/MS after oral administration of Salvia miltiorrhiza stem-leaf extracts
Wei Zhou,
Chengjing Sun,
Ruo-Ying Fan
и другие.
Heliyon,
Год журнала:
2024,
Номер
10(10), С. e30910 - e30910
Опубликована: Май 1, 2024
According
to
the
Standard
of
Chinese
Medicinal
Materials
Shaanxi
Province
(2015
edition),
Язык: Английский
Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models
Acta Pharmacologica Sinica,
Год журнала:
2023,
Номер
45(3), С. 465 - 479
Опубликована: Ноя. 28, 2023
Язык: Английский
Integrated pharmacokinetic-pharmacodynamic modeling and metabolomic research on polyphenol-rich fraction of Thymus quinquecostatus Celak. Alleviating cerebral ischemia-reperfusion injury
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
330, С. 118229 - 118229
Опубликована: Апрель 25, 2024
Язык: Английский
The compatibility rationality of Sijunzi decoction based on integrated analysis of tissue distribution and excretion characteristics in spleen deficiency syndrome rats
Journal of Ethnopharmacology,
Год журнала:
2023,
Номер
319, С. 117376 - 117376
Опубликована: Окт. 31, 2023
Язык: Английский
Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway
Journal of Pharmaceutical Analysis,
Год журнала:
2023,
Номер
14(3), С. 435 - 438
Опубликована: Сен. 27, 2023
•
DZSM
improves
cognition
by
facilitating
LTP.
regulates
the
NMDA
receptor-mediated
Ca
2+
/CaMKII
pathway.
Flavonoids
and
caffeoyl
compounds
are
active
components
of
DZSM.
Scutellarin
is
promising
to
treat
cognitive
deficits.
Язык: Английский
Development and validation of a dried blood spots assay for metabolic profiling of ginsenosides using ultra-high performance liquid chromatography-mass spectrometry
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
329, С. 118136 - 118136
Опубликована: Апрель 6, 2024
Язык: Английский
Implementing an Integrated Strategy to Realize the Transformation "from Spectral Data to Structure": Rapid Chemical Profiling of Dengzhan Shengmai Capsule Using Ultra-High Performance Liquid Chromatography in Conjunction with Q-Exactive Hybrid Quadrupole Orbitrap High-Resolution Mass Spectrometry
Опубликована: Янв. 1, 2024
A
swift
post-acquisition
processing
approach
was
proposed
to
examine
untargeted
mass
spectrometry
data
derived
from
ultra-high
performance
liquid
chromatography
coupled
with
hybrid
quadrupole
orbitrap
(UHPLC/Orbitrap-MS).
Dengzhan
Shengmai
Capsule
(DZSM)
utilized
as
a
case
study
demonstrate
this
methodology.
The
DZSM
chromatographically
separated
within
60-minute
timeframe
on
C18
column
(1.8
μm,
2.1
×
100
mm)
using
gradient
elution
acetonitrile
containing
0.1%
formic
acid
and
water
acid.
analytical
process
encompassed
three
key
stages.
spectral
underwent
filtration
generate
projected
composition
table
by
recognizing
high-resolution
precursor
ions
through
rapid
effective
similarity
analysis
Microsoft
Access
2021
software.
Fragmentation
patterns
of
diverse
constituents
were
consolidated
examining
MS/MS
spectra
16
selected
reference
compounds.
Subsequently,
diagnostic
ion
database
formulated
based
the
structures
compounds
sourced
four
herbal
medicines
that
constitute
DZSM,
documented
in
literature.
identified
then
verified
filtering
together
scrutinizing
their
MS
spectra.
Ultimately,
total
267
Capsule.
This
investigation
introduces
an
methodology
for
quick
chemical
traditional
Chinese
medicine
formulations.
Язык: Английский
The mysteries of pharmacokinetics and in vivo metabolism of Oroxylum indicum (L.) Kurz: A new perspective from MSOP method
Heliyon,
Год журнала:
2024,
Номер
10(12), С. e33234 - e33234
Опубликована: Июнь 1, 2024
The
pharmacological
effects
of
flavonoids
in
Oroxylum
indicum
(L.)
Kurz
against
inflammation,
bacterial,
and
oxidation
have
been
well-documented.
Additionally,
it
is
commonly
consumed
as
tea.
However,
the
vivo
mechanism
its
main
compounds
has
not
well
elucidated.
In
this
study,
a
highly
selective
sensitive
UHPLC-Q-TOF-MS
method
combined
with
Mass
Spectrum-based
Orthogonal
Projection
(MSOP)
theory
four-step
analytical
strategy
was
established
validated
to
identify
metabolites
rats
following
oral
administration
extract.
Furthermore,
LC-MS/MS
developed
for
first
time
analyze
pharmacokinetics
ten
rats.
Notably,
total
47
were
identified
blood,
bile,
urine,
feces
samples.
maximum
plasma
concentration
(Cmax)
values
oroxin
A,
B,
baicalin,
chrysin,
baicalein,
scutellarein,
apigenin,
quercetin
oroxylin
A
isorhamnetin
2945.1
±
11.23
ng/mL,
3123.9
16.37
130.40
27.52
117.20
28.54
64.12
19.33
97.22
24.27
145.22
29.92
45.19
18.84
67.32
15.78
ng/mL
128.44
26.42
ng/mL.
double
peak
observed
drug-time
curve
due
enterohepatic
recirculation.
This
study
demonstrated
that
MSOP
provided
more
technical
support
identification
flavonoid
complex
system
than
traditional
methods.
Язык: Английский