Development and validation of a dried blood spots assay for metabolic profiling of ginsenosides using ultra-high performance liquid chromatography-mass spectrometry DOI

Mengge Shi,

Han Han, Li Yang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118136 - 118136

Published: April 6, 2024

Language: Английский

Effects of scutellarin on the mechanism of cardiovascular diseases: a review DOI Creative Commons
Xinyu Zhang, Tong Yin,

Yincang Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Cardiovascular diseases represent a significant worldwide problem, jeopardizing individuals’ physical and mental wellbeing as well their quality of life result widespread incidence fatality. With the aging society, occurrence is progressively rising each year. However, although drugs developed for treating have clear targets proven efficacy, they still carry certain toxic side effect risks. Therefore, finding safe, effective, practical treatment options crucial. Scutellarin primary constituent Erigeron breviscapus (Vant.) Hand-Mazz. This article aims to establish theoretical foundation creation use secure, productive, logical medications in curing heart-related illnesses. Additionally, examination analysis signal pathway its associated mechanisms with regard employment SCU heart will impart innovative resolving concepts prevention diseases.

Language: Английский

Citations

3
Comparative pharmacokinetic study on phenolic acids and flavonoids in normal and microcirculation dysfunction rats plasma by UPLC-TQ/MS/MS after oral administration of Salvia miltiorrhiza stem-leaf extracts DOI Creative Commons
Wei Zhou,

Chengjing Sun,

Ruo-Ying Fan

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e30910 - e30910

Published: May 1, 2024

According to the Standard of Chinese Medicinal Materials Shaanxi Province (2015 edition),

Language: Английский

Citations

2
Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models DOI
Jun Wu, Miao Zhao,

Yuchen Jin

et al.

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 45(3), P. 465 - 479

Published: Nov. 28, 2023

Language: Английский

Citations

4
Integrated pharmacokinetic-pharmacodynamic modeling and metabolomic research on polyphenol-rich fraction of Thymus quinquecostatus Celak. Alleviating cerebral ischemia-reperfusion injury DOI
Xiaoyun Liu, Xueyang Ren,

Ruiwen Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 330, P. 118229 - 118229

Published: April 25, 2024

Language: Английский

Citations

1
The compatibility rationality of Sijunzi decoction based on integrated analysis of tissue distribution and excretion characteristics in spleen deficiency syndrome rats DOI
Bangjian Dong, Ying Peng, Mengyue Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117376 - 117376

Published: Oct. 31, 2023

Language: Английский

Citations

3
Implementing an Integrated Strategy to Realize the Transformation "from Spectral Data to Structure": Rapid Chemical Profiling of Dengzhan Shengmai Capsule Using Ultra-High Performance Liquid Chromatography in Conjunction with Q-Exactive Hybrid Quadrupole Orbitrap High-Resolution Mass Spectrometry DOI

Yehan Cai,

Yuqian Lin,

Wanping Zhou

et al.

Published: Jan. 1, 2024

A swift post-acquisition processing approach was proposed to examine untargeted mass spectrometry data derived from ultra-high performance liquid chromatography coupled with hybrid quadrupole orbitrap (UHPLC/Orbitrap-MS). Dengzhan Shengmai Capsule (DZSM) utilized as a case study demonstrate this methodology. The DZSM chromatographically separated within 60-minute timeframe on C18 column (1.8 μm, 2.1 × 100 mm) using gradient elution acetonitrile containing 0.1% formic acid and water acid. analytical process encompassed three key stages. spectral underwent filtration generate projected composition table by recognizing high-resolution precursor ions through rapid effective similarity analysis Microsoft Access 2021 software. Fragmentation patterns of diverse constituents were consolidated examining MS/MS spectra 16 selected reference compounds. Subsequently, diagnostic ion database formulated based the structures compounds sourced four herbal medicines that constitute DZSM, documented in literature. identified then verified filtering together scrutinizing their MS spectra. Ultimately, total 267 Capsule. This investigation introduces an methodology for quick chemical traditional Chinese medicine formulations.

Language: Английский

Citations

0
The mysteries of pharmacokinetics and in vivo metabolism of Oroxylum indicum (L.) Kurz: A new perspective from MSOP method DOI Creative Commons
Xia Zhang, Yuan Zhang, Na Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e33234 - e33234

Published: June 1, 2024

The pharmacological effects of flavonoids in Oroxylum indicum (L.) Kurz against inflammation, bacterial, and oxidation have been well-documented. Additionally, it is commonly consumed as tea. However, the vivo mechanism its main compounds has not well elucidated. In this study, a highly selective sensitive UHPLC-Q-TOF-MS method combined with Mass Spectrum-based Orthogonal Projection (MSOP) theory four-step analytical strategy was established validated to identify metabolites rats following oral administration extract. Furthermore, LC-MS/MS developed for first time analyze pharmacokinetics ten rats. Notably, total 47 were identified blood, bile, urine, feces samples. maximum plasma concentration (Cmax) values oroxin A, B, baicalin, chrysin, baicalein, scutellarein, apigenin, quercetin oroxylin A isorhamnetin 2945.1 ± 11.23 ng/mL, 3123.9 16.37 130.40 27.52 117.20 28.54 64.12 19.33 97.22 24.27 145.22 29.92 45.19 18.84 67.32 15.78 ng/mL 128.44 26.42 ng/mL. double peak observed drug-time curve due enterohepatic recirculation. This study demonstrated that MSOP provided more technical support identification flavonoid complex system than traditional methods.

Language: Английский

Citations

0
Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway DOI Creative Commons

Congyu Ma,

Ning Sheng, Jun Wu

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2023, Volume and Issue: 14(3), P. 435 - 438

Published: Sept. 27, 2023

• DZSM improves cognition by facilitating LTP. regulates the NMDA receptor-mediated Ca 2+ /CaMKII pathway. Flavonoids and caffeoyl compounds are active components of DZSM. Scutellarin is promising to treat cognitive deficits.

Language: Английский

Citations

1
Development and validation of a dried blood spots assay for metabolic profiling of ginsenosides using ultra-high performance liquid chromatography-mass spectrometry DOI

Mengge Shi,

Han Han, Li Yang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118136 - 118136

Published: April 6, 2024

Language: Английский

Citations

0