International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 27 - 27
Опубликована: Дек. 24, 2024
The
inflammatory
response
consists
of
two
stages:
priming
and
triggering.
triggering
stage
is
marked
by
the
activation
inflammasomes,
which
are
cytosolic
protein
complexes
acting
as
platforms
for
inflammation.
Inflammasomes
divided
into
canonical
noncanonical
categories.
Inflammatory
lung
diseases
such
asthma,
chronic
obstructive
pulmonary
disease
(COPD),
acute
respiratory
distress
syndrome
(ARDS),
injury,
fibrosis
arise
from
inflammation
damage.
While
role
inflammasomes
in
these
well
demonstrated,
recent
findings
emphasize
critical
roles
regulating
various
conditions.
Particularly,
new
studies
highlight
their
involvement
diseases.
This
review
delves
research
on
regulatory
human
caspase-4
murine
caspase-11,
development
diseases,
potential
targeting
treatments.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Targeted
regulation
of
pyroptosis
to
modulate
the
immune
landscape
has
emerged
as
a
novel
design
strategy
for
cancer
immunotherapy
and
anti‐inflammatory
therapy.
However,
acts
double‐edged
sword,
making
it
important
optimize
strategies
functional
materials
appropriately
activate
effective
disease
treatment.
This
paper
summarizes
discusses
structure,
pore
formation,
molecular
mechanisms
“executor”
Gasdermins,
well
events
preceding
following
these
processes.
Subsequently,
focus
is
on
reviewing
that
directly
regulate
Gasdermin
formation
target
those
indirectly
before
after
control
activity.
Finally,
advantages,
disadvantages,
future
prospects
designing
such
are
provided,
aiming
facilitate
precise
design,
pharmacological
investigation,
clinical
translation
pyroptosis‐related
materials.
Aging and Disease,
Год журнала:
2023,
Номер
14(6), С. 1981 - 1981
Опубликована: Янв. 1, 2023
Postoperative
cognitive
dysfunction
(POCD)
is
a
cluster
of
problems
that
may
arise
after
surgery.
POCD
symptoms
include
memory
loss,
focus
inattention,
and
communication
difficulties.
Inflammasomes,
intracellular
multiprotein
complexes
control
inflammation,
have
significant
role
in
the
development
POCD.
It
has
been
postulated
NLRP3
inflammasome
promotes
impairment
by
triggering
inflammatory
response
brain.
Nevertheless,
there
are
many
gaps
current
literature
to
understand
underlying
pathophysiological
mechanisms
develop
future
therapy.
This
review
article
underlines
limits
our
knowledge
about
(NOD-,
LRR-
pyrin
domain-containing
protein
3)
We
first
discuss
inflammasomes
their
types,
structures,
functions,
then
summarize
recent
evidence
inflammasome's
involvement
Next,
we
propose
hypothesis
suggests
multiple
organs,
including
local
surgical
sites,
blood
circulation,
other
peripheral
leading
systemic
inflammation
subsequent
neuronal
brain,
resulting
Research
directions
discussed,
analyses
more
clinical
animal
models
trials,
studies
types
involved
POCD,
investigations
into
whether
occur
at
site,
circulating
blood,
organs.
Finally,
potential
benefits
using
new
technologies
approaches
study
A
thorough
investigation
might
substantially
affect
practice.
Molecules,
Год журнала:
2023,
Номер
28(5), С. 2022 - 2022
Опубликована: Фев. 21, 2023
The
Artemisia
argyi
Lévl.
et
Van.
growing
in
the
surrounding
areas
of
Qichun
County
China
are
called
Qiai
(QA).
is
a
crop
that
can
be
used
both
as
food
and
traditional
folk
medicine.
However,
detailed
qualitative
quantitative
analyses
its
compounds
remain
scarce.
process
identifying
chemical
structures
complex
natural
products
streamlined
by
combining
UPLC-Q-TOF/MS
data
with
UNIFI
information
management
platform
embedded
Traditional
Medicine
Library.
For
first
time,
68
QA
were
reported
method
this
study.
simultaneous
quantification
14
active
components
using
UPLC-TQ-MS/MS
was
for
time.
Following
screening
activity
70%
methanol
total
extract
three
fractions
(petroleum
ether,
ethyl
acetate,
water),
it
discovered
acetate
fraction
enriched
flavonoids
such
eupatilin
jaceosidin
had
strongest
anti-inflammatory
activity,
while
water
chlorogenic
acid
derivatives
3,5-di-O-caffeoylquinic
antioxidant
antibacterial
activity.
results
provided
theoretical
basis
use
pharmaceutical
industries.
Phytochemical Analysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
Flavonoids
are
the
main
nonvolatile
component
responsible
for
anti-rheumatoid
arthritis
(RA)
synovitis
activities
of
Artemisia
argyi
Folium.
However,
effective
ingredient
remains
unidentified.
Spectrum-effect
relationships
analysis
was
a
reliable
and
efficient
strategy
herbal
discovery.
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5900 - 5900
Опубликована: Дек. 13, 2024
Quercetin
is
a
natural
polyphenolic
flavonoid
widely
found
in
plants,
fruits,
and
vegetables,
has
been
reported
to
play
pharmacological
roles
numerous
pathogenic
conditions.
The
anti-inflammatory
effects
of
quercetin
various
inflammatory
conditions
diseases
have
well-documented.
However,
its
regulatory
role
noncanonical
inflammasome
activation
not
yet
demonstrated.
This
study
investigated
the
caspase-11
inflammasome-activated
responses
macrophages
mouse
model
acute
lethal
sepsis.
protected
J774A.1
from
lipopolysaccharide
(LPS)-induced
cell
death
inflammasome-induced
pyroptosis.
It
significantly
decreased
production
mRNA
expression
pro-inflammatory
cytokines,
such
as
interleukin
(IL)-1β,
IL-18,
IL-6,
but
tumor
necrosis
factor
(TNF)-α,
molecules,
nitric
oxide
(NO)
inducible
NO
synthase
cells.
Mechanistically,
strongly
suppressed
autoproteolysis
secretion
proteolysis
gasdermin
D
did
inhibit
direct
binding
LPS.
In
vivo,
revealed
that
increased
survival
rate
mice
with
sepsis
serum
levels
cytokines
without
causing
significant
toxicity.
conclusion,
this
highlights
quercetin-mediated
action
through
novel
mechanism
targets
macrophages,
suggesting
promising
agent
medicine.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 14372 - 14372
Опубликована: Сен. 21, 2023
Among
the
plants
that
exhibit
significant
or
established
pharmacological
activity,
genus
Artemisia
L.
deserves
special
attention.
This
comprises
over
500
species
belonging
to
largest
Asteraceae
family.
Our
study
aimed
at
providing
a
comprehensive
evaluation
of
phytochemical
composition
ethanol
extracts
five
different
(collected
from
southwest
Russian
Federation)
and
their
antimicrobial
nematocide
activity
as
follows:
A.
annua
cv.
Novichok.,
dracunculus
Smaragd,
santonica
Citral,
abrotanum
Euxin,
scoparia
Tavrida.
The
using
methods
gas
chromatography–mass
spectrometry
(GC–MS)
high-performance
liquid
chromatography–quadrupole
time-of-flight
mass
(HPLC–MS/MS)
allowed
establishing
profile.
obtained
data
on
extracts’
were
used
predict
antibacterial
antifungal
against
phytopathogenic
microorganisms
nematocidal
free-living
soil
nematode
Caenorhabditis
elegans.
major
compounds
found
in
monoterpenes,
sesquiterpenes,
flavonoids,
flavonoid
glycosides,
coumarins,
phenolic
acids.
began
manifest
concentration
150
µg/mL.
Smaragd
extract
had
selective
effect
Gram-positive
R.
iranicus
B.
subtilis
bacteria,
whereas
Tavrida
Gram-negative
tumefaciens
X.
arboricola
bacteria
solani,
solani
F.
graminearum
fungi.
Novichok,
Citral
range
31.3–1000
µg/mL
caused
death
nematodes.
It
was
Novichok
affects
UNC-63
protein,
molecular
target
which
is
nicotine
receptor
N-subtype.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 14, 2023
Cecropin
AD
(CAD),
a
renowned
antimicrobial
peptide,
has
shown
promising
potential
in
treating
various
bacterial
infections.
This
study
investigates
the
protective
effects
of
CAD
against
lipopolysaccharide
(LPS)-induced
intestinal
adversities
chickens.
Sixty
SPF-grade
chicks
were
divided
into
groups
and
exposed
to
different
dosages
CAD,
followed
by
LPS
administration.
The
assessed
impact
on
mucosal
injury
markers,
oxidative
stress,
inflammation.
significantly
increased
Diamine
oxidase
(DAO)
D-lactate
(D-LA)
levels,
both
indicators
injury.
treatment
substantially
attenuated
these
elevations,
particularly
at
higher
dosages.
Additionally,
markedly
reduced
stress
tissues,
as
normalized
antioxidant
levels
decreased
reactive
oxygen
species.
Histological
analysis
supported
findings,
showing
better-preserved
villi
structures
CAD-treated
groups.
Furthermore,
IL-6
IL-8
expression
post-LPS
stimulation
effectively
regulated
NLRP3
inflammasome
pathway,
decreasing
associated
factors
like
NLRP3,
Caspase-1,
IL-1b,
IL-18.
demonstrates
CAD's
therapeutic
alleviating
LPS-induced
injuries.
are
primarily
attributed
its
anti-inflammatory
antioxidative
actions
modulation
pathway.