Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, acts double‐edged sword, making it important optimize strategies functional materials appropriately activate effective disease treatment. This paper summarizes discusses structure, pore formation, molecular mechanisms “executor” Gasdermins, well events preceding following these processes. Subsequently, focus is on reviewing that directly regulate Gasdermin formation target those indirectly before after control activity. Finally, advantages, disadvantages, future prospects designing such are provided, aiming facilitate precise design, pharmacological investigation, clinical translation pyroptosis‐related materials.

Язык: Английский

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Regulatory roles of noncanonical inflammasomes in kidney diseases

International Immunopharmacology, Год журнала: 2025, Номер 157, С. 114787 - 114787

Опубликована: Май 3, 2025

Язык: Английский

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Analysis of Acupoint Selection and Combination for Gouty Arthritis Treated with Moxibustion Based on Data Mining

Medical Acupuncture, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Язык: Английский

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Bridging the Gap: Investigating the Link between Inflammasomes and Postoperative Cognitive Dysfunction

Aging and Disease, Год журнала: 2023, Номер 14(6), С. 1981 - 1981

Опубликована: Янв. 1, 2023

Postoperative cognitive dysfunction (POCD) is a cluster of problems that may arise after surgery. POCD symptoms include memory loss, focus inattention, and communication difficulties. Inflammasomes, intracellular multiprotein complexes control inflammation, have significant role in the development POCD. It has been postulated NLRP3 inflammasome promotes impairment by triggering inflammatory response brain. Nevertheless, there are many gaps current literature to understand underlying pathophysiological mechanisms develop future therapy. This review article underlines limits our knowledge about (NOD-, LRR- pyrin domain-containing protein 3) We first discuss inflammasomes their types, structures, functions, then summarize recent evidence inflammasome's involvement Next, we propose hypothesis suggests multiple organs, including local surgical sites, blood circulation, other peripheral leading systemic inflammation subsequent neuronal brain, resulting Research directions discussed, analyses more clinical animal models trials, studies types involved POCD, investigations into whether occur at site, circulating blood, organs. Finally, potential benefits using new technologies approaches study A thorough investigation might substantially affect practice.

Язык: Английский

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UPLC-MS Analysis, Quantification of Compounds, and Comparison of Bioactivity of Methanol Extract and Its Fractions from Qiai (Artemisia argyi Lévl. et Van.)

Molecules, Год журнала: 2023, Номер 28(5), С. 2022 - 2022

Опубликована: Фев. 21, 2023

The Artemisia argyi Lévl. et Van. growing in the surrounding areas of Qichun County China are called Qiai (QA). is a crop that can be used both as food and traditional folk medicine. However, detailed qualitative quantitative analyses its compounds remain scarce. process identifying chemical structures complex natural products streamlined by combining UPLC-Q-TOF/MS data with UNIFI information management platform embedded Traditional Medicine Library. For first time, 68 QA were reported method this study. simultaneous quantification 14 active components using UPLC-TQ-MS/MS was for time. Following screening activity 70% methanol total extract three fractions (petroleum ether, ethyl acetate, water), it discovered acetate fraction enriched flavonoids such eupatilin jaceosidin had strongest anti-inflammatory activity, while water chlorogenic acid derivatives 3,5-di-O-caffeoylquinic antioxidant antibacterial activity. results provided theoretical basis use pharmaceutical industries.

Язык: Английский

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Screening Anti–Rheumatoid Arthritis Synovitis Effective Ingredients of Total Flavonoid From Artemisia argyi Folium Based on Spectrum–Effect Relationship

Phytochemical Analysis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Flavonoids are the main nonvolatile component responsible for anti-rheumatoid arthritis (RA) synovitis activities of Artemisia argyi Folium. However, effective ingredient remains unidentified. Spectrum-effect relationships analysis was a reliable and efficient strategy herbal discovery.

Язык: Английский

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Quercetin Ameliorates Acute Lethal Sepsis in Mice by Inhibiting Caspase-11 Noncanonical Inflammasome in Macrophages

Molecules, Год журнала: 2024, Номер 29(24), С. 5900 - 5900

Опубликована: Дек. 13, 2024

Quercetin is a natural polyphenolic flavonoid widely found in plants, fruits, and vegetables, has been reported to play pharmacological roles numerous pathogenic conditions. The anti-inflammatory effects of quercetin various inflammatory conditions diseases have well-documented. However, its regulatory role noncanonical inflammasome activation not yet demonstrated. This study investigated the caspase-11 inflammasome-activated responses macrophages mouse model acute lethal sepsis. protected J774A.1 from lipopolysaccharide (LPS)-induced cell death inflammasome-induced pyroptosis. It significantly decreased production mRNA expression pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-18, IL-6, but tumor necrosis factor (TNF)-α, molecules, nitric oxide (NO) inducible NO synthase cells. Mechanistically, strongly suppressed autoproteolysis secretion proteolysis gasdermin D did inhibit direct binding LPS. In vivo, revealed that increased survival rate mice with sepsis serum levels cytokines without causing significant toxicity. conclusion, this highlights quercetin-mediated action through novel mechanism targets macrophages, suggesting promising agent medicine.

Язык: Английский

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Five Different Artemisia L. Species Ethanol Extracts’ Phytochemical Composition and Their Antimicrobial and Nematocide Activity

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 14372 - 14372

Опубликована: Сен. 21, 2023

Among the plants that exhibit significant or established pharmacological activity, genus Artemisia L. deserves special attention. This comprises over 500 species belonging to largest Asteraceae family. Our study aimed at providing a comprehensive evaluation of phytochemical composition ethanol extracts five different (collected from southwest Russian Federation) and their antimicrobial nematocide activity as follows: A. annua cv. Novichok., dracunculus Smaragd, santonica Citral, abrotanum Euxin, scoparia Tavrida. The using methods gas chromatography–mass spectrometry (GC–MS) high-performance liquid chromatography–quadrupole time-of-flight mass (HPLC–MS/MS) allowed establishing profile. obtained data on extracts’ were used predict antibacterial antifungal against phytopathogenic microorganisms nematocidal free-living soil nematode Caenorhabditis elegans. major compounds found in monoterpenes, sesquiterpenes, flavonoids, flavonoid glycosides, coumarins, phenolic acids. began manifest concentration 150 µg/mL. Smaragd extract had selective effect Gram-positive R. iranicus B. subtilis bacteria, whereas Tavrida Gram-negative tumefaciens X. arboricola bacteria solani, solani F. graminearum fungi. Novichok, Citral range 31.3–1000 µg/mL caused death nematodes. It was Novichok affects UNC-63 protein, molecular target which is nicotine receptor N-subtype.

Язык: Английский

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Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome

Immunobiology, Год журнала: 2023, Номер 228(6), С. 152758 - 152758

Опубликована: Ноя. 1, 2023

Язык: Английский

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Protective role of Cecropin AD against LPS-induced intestinal mucosal injury in chickens

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Дек. 14, 2023

Cecropin AD (CAD), a renowned antimicrobial peptide, has shown promising potential in treating various bacterial infections. This study investigates the protective effects of CAD against lipopolysaccharide (LPS)-induced intestinal adversities chickens. Sixty SPF-grade chicks were divided into groups and exposed to different dosages CAD, followed by LPS administration. The assessed impact on mucosal injury markers, oxidative stress, inflammation. significantly increased Diamine oxidase (DAO) D-lactate (D-LA) levels, both indicators injury. treatment substantially attenuated these elevations, particularly at higher dosages. Additionally, markedly reduced stress tissues, as normalized antioxidant levels decreased reactive oxygen species. Histological analysis supported findings, showing better-preserved villi structures CAD-treated groups. Furthermore, IL-6 IL-8 expression post-LPS stimulation effectively regulated NLRP3 inflammasome pathway, decreasing associated factors like NLRP3, Caspase-1, IL-1b, IL-18. demonstrates CAD's therapeutic alleviating LPS-induced injuries. are primarily attributed its anti-inflammatory antioxidative actions modulation pathway.

Язык: Английский

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