Effects of Lycium barbarum Polysaccharides on Immunity and Metabolic Syndrome Associated with the Modulation of Gut Microbiota: A Review DOI Creative Commons

Cui Cao,

Zhongfu Wang, Guiping Gong

и другие.

Foods, Год журнала: 2022, Номер 11(20), С. 3177 - 3177

Опубликована: Окт. 12, 2022

Lycium barbarum polysaccharides (LBPs) have attracted increasing attention due to their multiple pharmacological activities and physiological functions. Recently, both in vitro vivo studies demonstrated that the biological effects of dietary LBPs are related regulation gut microbiota. Supplementation with could modulate composition microbial communities, simultaneously influence levels active metabolites, thus exerting beneficial on host health. Interestingly, diverse chemical structures may enrich or reduce certain specific intestinal microbes. The present review summarizes extraction, purification, structural types microbiome derived metabolites. Furthermore, health promoting bidirectional immunity (e.g., immune enhancement inflammation suppression) metabolic syndrome obesity, type 2 diabetes, nonalcoholic fatty liver disease) by targeting microbiota also discussed based types. contents presented this might help better understand benefits provide a scientific basis further clarify structure–function relationship LBPs.

Язык: Английский

Effects of polysaccharides from Fuzhuan brick tea on immune function and gut microbiota of cyclophosphamide-treated mice DOI

Yixuan Bai,

Ziqi Zeng,

Zhi Xie

и другие.

The Journal of Nutritional Biochemistry, Год журнала: 2022, Номер 101, С. 108947 - 108947

Опубликована: Янв. 10, 2022

Язык: Английский

Процитировано

44
Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice DOI Creative Commons
Yunping Tang,

Qiuyan Pu,

Qiaoling Zhao

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Май 19, 2022

The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated this work. Results indicated that LF significantly enhanced the spleen thymus indices, promoted lymphocyte peritoneal macrophages proliferation, increased immune-related cytokines production serum. Moreover, could regulate flora composition, increasing abundance Lactobacillaceae Alistipes , inhibiting Erysipelotrichia Turicibacter Romboutsia Peptostreptococcaceae Faecalibaculum . These results positively correlated with characteristics. Overall, be useful as a new potential strategy to mitigate CTX immunosuppression microbiota disorders.

Язык: Английский

Процитировано

42
Modulating the gut microbiota is involved in the effect of low-molecular-weight Glycyrrhiza polysaccharide on immune function DOI Creative Commons

Wangdi Song,

Yunyun Wang,

G. Li

и другие.

Gut Microbes, Год журнала: 2023, Номер 15(2)

Опубликована: Ноя. 10, 2023

Low molecular weight (6.5 kDa) Glycyrrhiza polysaccharide (GP) exhibits good immunomodulatory activity, however, the mechanism underlying GP-mediated regulation of immunity and gut microbiota remains unclear. In this study, we aimed to reveal mechanisms using cyclophosphamide (CTX)-induced immunosuppressed intestinal mucosal injury models. GP reversed CTX-induced structural damage increased number goblet cells, CD4+, CD8+ T lymphocytes, mucin content, particularly by maintaining balance helper lymphocyte 1/helper 2 (Th1/Th2). Moreover, alleviated immunosuppression down-regulating extracellular regulated protein kinases/p38/nuclear factor kappa-Bp50 pathways increasing short-chain fatty acids level secretion cytokines, including interferon-γ, interleukin (IL)-4, IL-2, IL-10, IL-22, transforming growth factor-β3 immunoglobulin (Ig) M, IgG secretory A. treatment total species diversity microbiota. Microbiota analysis showed that promoted proliferation beneficial bacteria, Muribaculaceae_unclassified, Alistipes, Lachnospiraceae_NK4A136_group, Ligilactobacillus, Clostridia_vadinBB60_group, reduced abundance Proteobacteria CTX-derived bacteria (Clostridiales_unclassified, Candidatus_Arthromitus, Firmicutes_unclassified, Clostridium). The studies fecal transplantation pseudo-aseptic model conformed is crucial in regulation. shows great potential as an immune enhancer a natural medicine for treating inflammatory diseases.

Язык: Английский

Процитировано

39
New insights into bee pollen: Nutrients, phytochemicals, functions and wall-disruption DOI
Jiangtao Qiao, Yu Zhang, Éric Haubruge

и другие.

Food Research International, Год журнала: 2024, Номер 178, С. 113934 - 113934

Опубликована: Янв. 4, 2024

Язык: Английский

Процитировано

13
Dendrobium officinale leaf polysaccharide has a dual effect of alleviating the syndromes of immunosuppressed mice and modulating immune system of normal mice DOI Creative Commons
Jingrui Li, Wenyang Tao, Wanyi Zhou

и другие.

Journal of Functional Foods, Год журнала: 2024, Номер 113, С. 105974 - 105974

Опубликована: Янв. 10, 2024

This study aimed to explore the immunomodulatory activity of Dendrobium officinale leaf polysaccharide (DOLP) in both immunosuppressed and normal mice. The data showed that DOLP significantly reversed thymic splenic damage mice, regulated their peripheral blood cells (PLT, etc.), immune-related cytokines (TNF-α, INF-γ IL-6) immunoglobulins (IgA, IgG IgM) production, increased relative abundance beneficial bacteria (Lactobacillus Bifidobacterium, etc.) while decreased pathogenic (Desulfovibrio, etc.). In INF-γ, IL-6), gut microbiota diversity, (unclassified_f_Lachnospiraceae_NK4A136_group, results indicated could exert immune modulating effects on mice by parameters microbiota. These findings provide new insights into immune-modulating a solid basis for thorough utilization DOLP.

Язык: Английский

Процитировано

10
Amelioration of Obesity‐Related Disorders in High‐Fat Diet‐Fed C57BL/6 Mice Following Fecal Microbiota Transplantation From DL‐Norvaline‐Dosed Mice DOI Open Access
Xin Li,

Bohan Sun,

Yanting Qin

и другие.

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

ABSTRACT Fecal microbiota transplantation (FMT) could significantly alter the recipient's gut bacteria composition and attenuate obesity obesity‐related metabolic syndromes. DL‐norvaline is a nonproteinogenic amino acid possesses anti‐obesity potential. However, specific mechanisms by which might mediate beneficial effects of have not been completely elucidated. In this study, DL‐norvaline‐mediated FMT upregulated ( Clostridia_UCG_014 , Christensenellales Bacilli Ileibacterium Dubosiella Lactobacillus Muribaculaceae Bacteroidaceae ) downregulated harmful Tuzzerella Marinifilaceae ), further intestinal inflammation, oxidative stress, barrier were alleviated as well short chain fatty acids levels increased, thus alleviating glucose insulin metabolism, improving biochemical indexes energy metabolism decreasing body weight gain tissue weight. heat‐inactivated did demonstrate any those improvements in obese mice. Notably, both increased being signature alterations to marker caused DL‐norvaline. Therefore, transmissible via FMT. This study highlighted pivotal involvement development provided novel insight into underlying FMT, thereby potentially enhancing efficacy refinement utilization.

Язык: Английский

Процитировано

2
Lactiplantibacillus plantarum improves the growth performance and meat quality of broilers by regulating the cecal microbiota and metabolites DOI Creative Commons
Yu Liu, Zhisheng Wang,

Xi Wu

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Янв. 28, 2025

Gut microbiota can digest and ferment feed into metabolites to influence the meat quality. Probiotics are used regulate gut microbiota. In this study, a total of 360 broilers were assigned 4 treatments (10 per cage): control (Con), low dose Lactiplantibacillus plantarum HW1 (Lp_L), medium Lp (Lp_M) high (Lp_H) for 42-day experimental period. Results showed that improved growth performance, carcass traits, breast quality, also influenced fatty acids composition, including decrease n-6PUFA/n-3PUFA, increase C18:3n3, ∑n-3PUFA PUFA/SFA. The lipid metabolism-related gene expressions in liver increased expression AMPK , CPT-1α PPARα ATGL decreased PPARγ SREBP-1c ACC FAS LPL SCD . Moreover, abundances microbiota, such as Synergistaceae Synergistes by treatments. Functional prediction indicated pathways, pancreatic secretion spliceosome enriched Untargeted metabolomics revealed altered content metabolites, 6-ketomyristic acid indole-3-acetamide. These pathways metabolism. Correlation analyses potential interactions between performance well ( etc.) (6-ketomyristic acid, etc.). Overall, our data show significantly traits quality regulating acids, metabolites.

Язык: Английский

Процитировано

1
Sulfated modification enhances the modulatory effect of yam polysaccharide on gut microbiota in cyclophosphamide-treated mice DOI
Rong Huang, Jianhua Xie, Xuan Liu

и другие.

Food Research International, Год журнала: 2021, Номер 145, С. 110393 - 110393

Опубликована: Май 14, 2021

Язык: Английский

Процитировано

54
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice DOI Creative Commons
Xingwei Xiang, Huizhen Zheng, Rui Wang

и другие.

Marine Drugs, Год журнала: 2021, Номер 19(8), С. 456 - 456

Опубликована: Авг. 11, 2021

The intestinal flora is recognized as a significant contributor to the immune system. In this research, protective effects of oyster peptides on regulation and microbiota were investigated in mice treated with cyclophosphamide. results showed that restored indexes thymus, spleen liver, stimulated cytokines secretion promoted relative mRNA levels Th1/Th2 (IL-2, IFN-γ, IL-4 IL-10). Occludin, Claudin-1, ZO-1, Mucin-2 up-regulated, NF-κB signaling pathway was also activated after administration. Furthermore, treatment reduced proportion Firmicutes/Bacteroidetes, increased abundance Alistipes, Lactobacillus, Rikenell content short-chain fatty acids, reversed composition microflora similar normal mice. conclusion, effectively ameliorated cyclophosphamide-induced damage modified gut structure mice, might be utilized beneficial ingredient functional foods for regulation.

Язык: Английский

Процитировано

53
Polysaccharides From the Roots of Millettia Speciosa Champ Modulate Gut Health and Ameliorate Cyclophosphamide-Induced Intestinal Injury and Immunosuppression DOI Creative Commons
Xiaogang Chen, Wenjing Sun, Baichang Xu

и другие.

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Окт. 21, 2021

Cyclophosphamide (CTX), a common anticancer drug, can cause variety of side effects such as immunosuppression and intestinal mucosal injury. Polysaccharides are the major bioactive components roots Millettia Speciosa Champ have gained attention for their immunomodulatory activity. This study was designed to evaluate effect polysaccharide (MSCP) on CTX-induced mice possible mechanism. The results showed that MSCP attenuated decrease in body weight immune organ indices promoted secretion immune-related cytokines (IL-2, IL-4, IL-10, TNF-α, IgG). Meanwhile, restored morphology, increased ratio villus height/crypt depth (V/C), improved number goblet cells mucins expression. At mRNA level, activated TLRs/MyD88/NF-κB p65 pathway enhanced expression genes related integrity (Occludin1, Claudin1, MUC-2). In addition, prebiotic microbial community diversity, regulated relative abundance dominant microbiota from phylum level genus gut dysbiosis, short-chain fatty acid production mice. Based present findings, may modulate response depending enhancing health, suggesting holds promise promising immunostimulant functional foods drugs.

Язык: Английский

Процитировано

53