Ameliorative effect of total ginsenosides from heat-treated fresh ginseng against cyclophosphamide-induced liver injury in mice DOI Creative Commons
Ping Tang,

Guangquan Ren,

Hongyang Zou

et al.

Current Research in Food Science, Journal Year: 2024, Volume and Issue: 8, P. 100734 - 100734

Published: Jan. 1, 2024

This study evaluated the effect of heat treatment on conversion ginsenoside and ameliorative heat-treated total (HG) from fresh ginseng cyclophosphamide (CTX)-induced liver injury. LC-MS analysis revealed that content rare ginsenosides increased markedly after treatment. HG significantly attenuated CTX-induced hepatic histopathological injury in mice. Western blotting showed untreated (UG) regulated Nrf2/HO-1 TLR4/MAPK pathways. Importantly, these results may be relevant to modulation intestinal flora. UG short-chain fatty acids (SCFAs)-producing bacteria Lactobacillus reduced LPS-producing Bacteroides Parabacteroides. These changes flora affected levels TNF-α, LPS SCFAs. In short, alleviated by regulating LPS-TLR4-MAPK pathway, was more effective. has potential a functional food can alleviate chemical

Language: Английский

Amelioration of Obesity‐Related Disorders in High‐Fat Diet‐Fed C57BL/6 Mice Following Fecal Microbiota Transplantation From DL‐Norvaline‐Dosed Mice DOI Open Access
Xin Li,

Bohan Sun,

Yanting Qin

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

ABSTRACT Fecal microbiota transplantation (FMT) could significantly alter the recipient's gut bacteria composition and attenuate obesity obesity‐related metabolic syndromes. DL‐norvaline is a nonproteinogenic amino acid possesses anti‐obesity potential. However, specific mechanisms by which might mediate beneficial effects of have not been completely elucidated. In this study, DL‐norvaline‐mediated FMT upregulated ( Clostridia_UCG_014 , Christensenellales Bacilli Ileibacterium Dubosiella Lactobacillus Muribaculaceae Bacteroidaceae ) downregulated harmful Tuzzerella Marinifilaceae ), further intestinal inflammation, oxidative stress, barrier were alleviated as well short chain fatty acids levels increased, thus alleviating glucose insulin metabolism, improving biochemical indexes energy metabolism decreasing body weight gain tissue weight. heat‐inactivated did demonstrate any those improvements in obese mice. Notably, both increased being signature alterations to marker caused DL‐norvaline. Therefore, transmissible via FMT. This study highlighted pivotal involvement development provided novel insight into underlying FMT, thereby potentially enhancing efficacy refinement utilization.

Language: Английский

Citations

2
Effects of polysaccharides from Fuzhuan brick tea on immune function and gut microbiota of cyclophosphamide-treated mice DOI

Yixuan Bai,

Ziqi Zeng,

Zhi Xie

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2022, Volume and Issue: 101, P. 108947 - 108947

Published: Jan. 10, 2022

Language: Английский

Citations

44
Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice DOI Creative Commons
Yunping Tang,

Qiuyan Pu,

Qiaoling Zhao

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 19, 2022

The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated this work. Results indicated that LF significantly enhanced the spleen thymus indices, promoted lymphocyte peritoneal macrophages proliferation, increased immune-related cytokines production serum. Moreover, could regulate flora composition, increasing abundance Lactobacillaceae Alistipes , inhibiting Erysipelotrichia Turicibacter Romboutsia Peptostreptococcaceae Faecalibaculum . These results positively correlated with characteristics. Overall, be useful as a new potential strategy to mitigate CTX immunosuppression microbiota disorders.

Language: Английский

Citations

40
Modulating the gut microbiota is involved in the effect of low-molecular-weight Glycyrrhiza polysaccharide on immune function DOI Creative Commons

Wangdi Song,

Yunyun Wang,

G. Li

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Nov. 10, 2023

Low molecular weight (6.5 kDa) Glycyrrhiza polysaccharide (GP) exhibits good immunomodulatory activity, however, the mechanism underlying GP-mediated regulation of immunity and gut microbiota remains unclear. In this study, we aimed to reveal mechanisms using cyclophosphamide (CTX)-induced immunosuppressed intestinal mucosal injury models. GP reversed CTX-induced structural damage increased number goblet cells, CD4+, CD8+ T lymphocytes, mucin content, particularly by maintaining balance helper lymphocyte 1/helper 2 (Th1/Th2). Moreover, alleviated immunosuppression down-regulating extracellular regulated protein kinases/p38/nuclear factor kappa-Bp50 pathways increasing short-chain fatty acids level secretion cytokines, including interferon-γ, interleukin (IL)-4, IL-2, IL-10, IL-22, transforming growth factor-β3 immunoglobulin (Ig) M, IgG secretory A. treatment total species diversity microbiota. Microbiota analysis showed that promoted proliferation beneficial bacteria, Muribaculaceae_unclassified, Alistipes, Lachnospiraceae_NK4A136_group, Ligilactobacillus, Clostridia_vadinBB60_group, reduced abundance Proteobacteria CTX-derived bacteria (Clostridiales_unclassified, Candidatus_Arthromitus, Firmicutes_unclassified, Clostridium). The studies fecal transplantation pseudo-aseptic model conformed is crucial in regulation. shows great potential as an immune enhancer a natural medicine for treating inflammatory diseases.

Language: Английский

Citations

38
New insights into bee pollen: Nutrients, phytochemicals, functions and wall-disruption DOI
Jiangtao Qiao, Yu Zhang, Éric Haubruge

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 178, P. 113934 - 113934

Published: Jan. 4, 2024

Language: Английский

Citations

13
Structural characterization of the exopolysaccharide produced by Bacillus amyloliquefaciens JM033 and evaluation of its ability to regulate immunity and intestinal flora DOI
Hongxuan Li, Yubo Zhang, Yaping Zheng

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141052 - 141052

Published: Feb. 20, 2025

Language: Английский

Citations

1
Sulfated modification enhances the modulatory effect of yam polysaccharide on gut microbiota in cyclophosphamide-treated mice DOI
Rong Huang, Jianhua Xie, Xuan Liu

et al.

Food Research International, Journal Year: 2021, Volume and Issue: 145, P. 110393 - 110393

Published: May 14, 2021

Language: Английский

Citations

52
Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice DOI Creative Commons
Xingwei Xiang, Huizhen Zheng, Rui Wang

et al.

Marine Drugs, Journal Year: 2021, Volume and Issue: 19(8), P. 456 - 456

Published: Aug. 11, 2021

The intestinal flora is recognized as a significant contributor to the immune system. In this research, protective effects of oyster peptides on regulation and microbiota were investigated in mice treated with cyclophosphamide. results showed that restored indexes thymus, spleen liver, stimulated cytokines secretion promoted relative mRNA levels Th1/Th2 (IL-2, IFN-γ, IL-4 IL-10). Occludin, Claudin-1, ZO-1, Mucin-2 up-regulated, NF-κB signaling pathway was also activated after administration. Furthermore, treatment reduced proportion Firmicutes/Bacteroidetes, increased abundance Alistipes, Lactobacillus, Rikenell content short-chain fatty acids, reversed composition microflora similar normal mice. conclusion, effectively ameliorated cyclophosphamide-induced damage modified gut structure mice, might be utilized beneficial ingredient functional foods for regulation.

Language: Английский

Citations

52
Polysaccharides From the Roots of Millettia Speciosa Champ Modulate Gut Health and Ameliorate Cyclophosphamide-Induced Intestinal Injury and Immunosuppression DOI Creative Commons
Xiaogang Chen, Wenjing Sun, Baichang Xu

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 21, 2021

Cyclophosphamide (CTX), a common anticancer drug, can cause variety of side effects such as immunosuppression and intestinal mucosal injury. Polysaccharides are the major bioactive components roots Millettia Speciosa Champ have gained attention for their immunomodulatory activity. This study was designed to evaluate effect polysaccharide (MSCP) on CTX-induced mice possible mechanism. The results showed that MSCP attenuated decrease in body weight immune organ indices promoted secretion immune-related cytokines (IL-2, IL-4, IL-10, TNF-α, IgG). Meanwhile, restored morphology, increased ratio villus height/crypt depth (V/C), improved number goblet cells mucins expression. At mRNA level, activated TLRs/MyD88/NF-κB p65 pathway enhanced expression genes related integrity (Occludin1, Claudin1, MUC-2). In addition, prebiotic microbial community diversity, regulated relative abundance dominant microbiota from phylum level genus gut dysbiosis, short-chain fatty acid production mice. Based present findings, may modulate response depending enhancing health, suggesting holds promise promising immunostimulant functional foods drugs.

Language: Английский

Citations

52
Ascorbic Acid Derivative 2-O-β-d-Glucopyranosyl-l-Ascorbic Acid from the Fruit of Lycium barbarum Modulates Microbiota in the Small Intestine and Colon and Exerts an Immunomodulatory Effect on Cyclophosphamide-Treated BALB/c Mice DOI
Kaiyin Huang,

Yamei Yan,

Dan Chen

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2020, Volume and Issue: 68(40), P. 11128 - 11143

Published: Aug. 21, 2020

2-O-β-d-Glucopyranosyl-l-ascorbic acid (AA-2βG) is a natural and stable ascorbic derivative isolated from the fruits of Lycium barbarum. In our present study, cyclophosphamide (Cy) was used to make BALB/c mice immunosuppressive AA-2βG intervene mice. It found that Cy treatment resulted in series changes on basic immune indexes including decrease thymus spleen levels pro-inflammatory cytokines destruction leucocyte proportion balance, accompanied with weight loss, reduction colon length, hepatic function markers. However, all these were reversed varying degrees by intervention. Notably, could significantly change both mouse colonic small-intestinal microbiota. The key responsive taxa Muribaculaceae, Ruminococcaceae, Oscillibacter, Rikenella, Helicobacter, Negativibacillus, Alistipes, Roseburia, small intestine Anaerotruncus, Paenibacillus. results demonstrated modulate microbiota exert an immunomodulatory effect. Further studies should focus degradation pathways interaction between Muribaculaceae.

Language: Английский

Citations

51