Environmental Research, Год журнала: 2024, Номер 250, С. 118506 - 118506
Опубликована: Фев. 20, 2024
Язык: Английский
Environment International, Год журнала: 2022, Номер 171, С. 107662 - 107662
Опубликована: Ноя. 26, 2022
Exposure to micro- and nanoplastics (MNPs) is inevitable due their omnipresence in the environment. A growing body of studies has advanced our understanding potential toxicity MNPs but knowledge gaps still exist regarding adverse effects on cardiovascular system underlying mechanisms, particularly humans. Here, we reviewed up-to-date data published past 10 years MNP-driven mechanisms. Forty-six articles concerning ADME (absorption, distribution, aggregation behaviors) circulatory animals human cells were analyzed summarized. The results showed that affected cardiac functions caused (micro)vascular sites. Direct included abnormal heart rate, function impairment, pericardial edema, myocardial fibrosis. On sites, induced hemolysis, thrombosis, blood coagulation, vascular endothelial damage. main mechanisms oxidative stress, inflammation, apoptosis, pyroptosis, interaction between multiple cellular components. Cardiovascular was determined by properties (type, size, surface, structure) MNPs, exposure dose duration, protein presence, life stage, sex, species tested organisms, as well with other environmental contamination. limited quantitative information MNPs' lack guidelines for MNP cardiotoxicity testing makes risk assessment health impossible. Furthermore, future directions research are recommended enable more realistic assessment.
Язык: Английский
Процитировано
152
The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 168946 - 168946
Опубликована: Дек. 2, 2023
Язык: Английский
Процитировано
124
The Science of The Total Environment, Год журнала: 2023, Номер 903, С. 166766 - 166766
Опубликована: Сен. 2, 2023
Язык: Английский
Процитировано
73
Advanced Science, Год журнала: 2023, Номер 10(19)
Опубликована: Май 5, 2023
Abstract Exposure to micro‐ and nanoplastics (MNPs) is common because of their omnipresence in environment. Recent studies have revealed that MNPs may cause atherosclerosis, but the underlying mechanism remains unclear. To address this bottleneck, ApoE −/− mice are exposed 2.5–250 mg kg −1 polystyrene (PS‐NPs, 50 nm) by oral gavage with a high‐fat diet for 19 weeks. It found PS‐NPs blood aorta mouse exacerbate artery stiffness promote atherosclerotic plaque formation. activate phagocytosis M1‐macrophage aorta, manifesting as upregulation macrophage receptor collagenous structure (MARCO). Moreover, disrupt lipid metabolism increase long‐chain acyl carnitines (LCACs). LCAC accumulation attributed PS‐NP‐inhibited hepatic carnitine palmitoyltransferase 2. PS‐NPs, well LCACs alone, aggravate via upregulating MARCO oxidized low‐density lipoprotein‐activated foam cells. Finally, synergistic effects on increasing total cholesterol cells found. Overall, study indicates PS‐NP‐induced atherosclerosis MARCO. This offers new insight into mechanisms MNP‐induced cardiovascular toxicity, highlights combined endogenous metabolites system, which warrant further study.
Язык: Английский
Процитировано
49
Particle and Fibre Toxicology, Год журнала: 2023, Номер 20(1)
Опубликована: Ноя. 22, 2023
Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, have raised concerns regarding their potential risks to health, particularly neurotoxicity. This study aimed investigate the deleterious effects of polystyrene (PS-NPs, 50 nm) understand mechanisms inducing Parkinson's disease (PD)-like neurodegeneration, along with exploring preventive strategies.
Язык: Английский
Процитировано
46
Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 134054 - 134054
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
37
Environmental Health Perspectives, Год журнала: 2024, Номер 132(4)
Опубликована: Апрель 1, 2024
Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much these end up in oceans or landfills leading to a substantial accumulation environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled ingested by both animals and humans. A growing body evidence indicates MPs cross gut barrier enter lymphatic systemic circulation tissues such as lungs, liver, kidney, brain. The impacts mixed exposure on tissue function through metabolism remains largely unexplored.
Язык: Английский
Процитировано
31
The Science of The Total Environment, Год журнала: 2024, Номер 924, С. 171681 - 171681
Опубликована: Март 13, 2024
Nanoplastics, arising from the fragmentation of plastics into environmental pollutants and specialized commercial applications, such as cosmetics, have elicited concerns due to their potential toxicity. Evidence suggests that oral ingestion nanoplastics smaller than 100 nm may penetrate brain induce neurotoxicity. However, comprehensive research in this area has been hampered by technical challenges associated with detection synthesis nanoplastics. This study aimed bridge gap successfully synthesizing fluorescent polystyrene (PSNPs, 30–50 nm) through incorporation IR-813 validating them using various analytical techniques. We administered PSNPs orally (10 20 mg/kg/day) mice observed they reached tissues induced cognitive dysfunction, measured spatial fear memory tests, while locomotor social behaviors remained unaffected. In vitro studies (200 μg/mL) demonstrated a predominant uptake microglia over astrocytes or neurons, leading microglial activation, evidenced immunostaining cellular markers morphological analysis. Transcriptomic analysis indicated altered gene expression microglia, highlighting neuroinflammatory responses contribute deficits. To further explore neurotoxic effects mediated we endogenous neuronal activity multi-electrode array cultured hippocampal neurons. The application conditioned media exposed suppressed activity, which was reversed inhibitors activation. Our findings offer detailed insights mechanisms damage brain, particularly emphasizing risk factors impairment neurodegenerative diseases.
Язык: Английский
Процитировано
29
The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170739 - 170739
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
24
Environment International, Год журнала: 2024, Номер 185, С. 108523 - 108523
Опубликована: Март 1, 2024
Microplastics (MPs) are inevitably oxidized in the environment, and their potential toxicity to organisms has attracted wide attention. However, neurotoxicity mechanism of polyethylene (Ox-PE) MPs remain unclear. Herein, we prepared low-density (Ox-LDPE) established a model exposure by continuously orally gavage C57BL/6 J mice with LDPE-MPs/Ox-LDPE-MPs for 28 days or without oral administration Lactobacillus plantarum DP189 galactooligosaccharides (DP189&GOS). The experimental results indicated that LDPE-MPs Ox-LDPE-MPs caused several adverse effects mice, mainly manifested behavioral changes, disruption intestinal blood–brain barrier (BBB), simultaneous oxidative stress, inflammatory reactions, pathological damage brain intestines. Brain transcriptomic analysis revealed cholinergic synaptic signaling pathways, which affect cognitive function, were significantly disrupted after Ox-LDPE-MPs. Real-time quantitative polymerase chain reaction Western Blotting further demonstrated critical genes (Slc5a7, Chat Slc18a3) proteins (Chat pathway down-regulated These alterations lead reduced acetylcholine concentration, causes dysfunction mice. Importantly, DP189&GOS interventions effectively mitigated MPs-induced microbiota alteration, improved BBB integrity, attenuated stress response, also saw rebound release acetylcholine. exert neurotoxic on inducing responses, dysregulation pathways mouse brain. That probiotic supplementation is effective attenuating Overall, this study reveals mechanisms improvement measures, necessary assess risks plastic contaminants human health.
Язык: Английский
Процитировано
24