Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review

Polymers, Год журнала: 2024, Номер 16(19), С. 2807 - 2807

Опубликована: Окт. 3, 2024

The extensive use of polymeric materials has resulted in significant environmental pollution, prompting the need for a deeper understanding their degradation processes and impacts. This review provides comprehensive analysis environment impact on health experimental animals. It identifies common polymers, delineates pathways, describes resulting products under different conditions. covers physical, chemical, biological mechanisms, highlighting complex interplay factors influencing these processes. Furthermore, it examines implications products, using animals as proxies assessing potential risks to human health. By synthesizing current research, focuses studies related small organisms (primarily rodents invertebrates, supplemented by fish mollusks) explore effects polymer living underscores urgency developing implementing effective waste management strategies. These strategies are crucial mitigating adverse impacts degradation, thus promoting more sustainable interaction between activities natural environment.

Язык: Английский

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The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity?

Toxicology, Год журнала: 2024, Номер 504, С. 153799 - 153799

Опубликована: Апрель 11, 2024

Язык: Английский

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Positively Charged Nanoplastics Destruct the Structure of the PCK1 Enzyme, Promote the Aerobic Gycolysis Pathway, and Induce Hepatic Tumor Risks

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

The production and weathering processes of nanoparticles (NPs) introduce charged functional groups on their surface. Previous studies have found that the surface charge properties NPs play a critical role in toxic effects mechanisms are generally attributed to different accumulations transmembrane potentials. Currently, we still lack sufficient knowledge about effects, owing unique structures these polymers. In this study, positively (PS-NH2, 50 nm) at 0.05-0.5 μg mL-1 promoted proliferation hepatic tumors oncogenic KrasG12V zebrafish larvae they also increased viability human hepatocellular carcinoma cells, whereas negatively (PS-COOH, did not. We present evidence indicating potential carcinogenicity PS-NH2 is related special polymer-molecular interactions caused by its positive charge. affinity PS-COOH chains for peptides typically enhances enzyme stability upregulates expression. However, strongly competes with hydrogen bonds first rate-limiting PCK1 gluconeogenesis, thus downregulating expression promoting aerobic glycolysis pathway, which most tumor cells prefer. This study indicates positive-charge modified environment may bring additional carcinogenic risks.

Язык: Английский

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Blood-brain barrier damage accelerates the accumulation of micro- and nanoplastics in the human central nervous system

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136028 - 136028

Опубликована: Окт. 2, 2024

Язык: Английский

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Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review

Cancers, Год журнала: 2024, Номер 16(21), С. 3703 - 3703

Опубликована: Ноя. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Язык: Английский

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Oral Exposure to Microplastics Affects the Neurochemical Plasticity of Reactive Neurons in the Porcine Jejunum

Nutrients, Год журнала: 2024, Номер 16(14), С. 2268 - 2268

Опубликована: Июль 14, 2024

Plastics are present in almost every aspect of our lives. Polyethylene terephthalate (PET) is commonly used the food industry. Microparticles can contaminate and drinks, posing a threat to consumers. The presented study aims determine effect microparticles PET on population neurons positive for selected neurotransmitters enteric nervous system jejunum histological structure. An amount 15 pigs were divided into three groups (control, receiving 0.1 g, 1 g/day/animal orally). After 28 days, fragments collected immunofluorescence examination. obtained results show that changes (injury apical parts villi, accumulations cellular debris mucus, eosinophil infiltration, hyperaemia) more pronounced higher dose microparticles. neuronal nitric oxide synthase-, substance P-positive neurons, depends examined plexus increase percentage galanin-positive decrease cocaine amphetamine-regulated transcript-, vesicular acetylcholine transporter-, vasoactive intestinal peptide-positive do not such relationships. shows potentially have neurotoxic pro-inflammatory effects, but there need further research mechanism this process possible effects.

Язык: Английский

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Mechanisms Underlying the Size-Dependent Neurotoxicity of Polystyrene Nanoplastics in Zebrafish

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Nanoplastics (NPs) are ubiquitous in the environment, posing significant threats to biological systems, including nervous across various trophic levels. Nevertheless, molecular mechanisms behind size-dependent neurotoxicity of NPs remain unclear. Here, we investigated 20 and 100 nm polystyrene (PS-NPs) zebrafish. Utilizing dynamics simulations complementary methods, discovered that PS-NPs initiated by promoting dimerization toll-like receptor 4/myeloid differentiation-2 (TLR4/MD-2) complex. This process involves binding hydrophobic pocket MD-2, which induced flipping Phe-126 toward dimer interface bending C-terminal domain TLR-4, bringing two domains into close proximity. Thereafter, astrocytes microglia were activated, initiating a cascade events include neuroinflammation, central system cell apoptosis, inhibition motor neuron development, ultimately alteration swimming behavior Further, elicited more severe than PS-NPs, attributed their higher accumulation brain as determined through 14C-labeled effective interaction with TLR4/MD-2 Overall, our study uncovers underlying NPs, merit attention during risk assessment regulation.

Язык: Английский

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Rethinking Depression—Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression’s Pathophysiology and Tailored Treatment

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2759 - 2759

Опубликована: Март 19, 2025

It is known that the effectiveness of drug treatment for depression, ammine deficit based, largely unsatisfactory. In this review, we examine proposal a precision therapy has emerged and received strong push by identification role inflammation in depression. However, psychiatry risks being caught reductionist trap searching molecular switch resets whole system switches off disease. This an illusion since human complex depression systemic variable disorder. study, show inadequacy paradigm, and, at same time, illustrate superiority paradigm centered on psychoneuroendocrineimmunology (PNEI). According to PNEI disease being, caused different sources working together: psychological, biological, behavioral. means knowing biological psychological history subject, identifying relational crisis factors, building personalized treatments targeting those factors with tools medicine psychology, which are not reducible combination drugs psychotherapy. Our presents shift both theoretical practical, enables clinicians assess patients experiencing unified way treat them integrated manner.

Язык: Английский

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Association between microplastics exposure and depressive symptoms in college students

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 295, С. 118142 - 118142

Опубликована: Апрель 1, 2025

Microplastics (MP) are pervasive environmental pollutants that have raised concerns regarding their potential health effects. However, limited studies investigated the relationship between MP exposure and depression, particularly in college students. Our study aims to examine association depressive symptoms A total of 1420 students from Jiangsu College Nursing, China, were included this cross-sectional study. Depressive assessed using Patient Health Questionnaire-2 (PHQ-2), was estimated based on daily airborne concentration drinking-water levels. Multivariate logistic regression models used estimate associations symptoms. The prevalence among 61.8 %. median (interquartile range) 17403.7 (14174.8-20995.9) particles/day. Airborne exhibited positive with symptoms, while no significant found Compared participants lowest quartile exposure, those highest had 38 % higher odds experiencing (odds ratio [OR] = 1.38, 95 CI: 1.21-1.57). When treated as a continuous variable, each 1000-particle increase associated 7.0 (OR 1.07, 1.04-1.10). Stratified analyses indicated stronger male freshmen. This suggests is contributing factor for

Язык: Английский

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Perinatal exposure to polystyrene nanoplastics alters socioemotional behaviors via the microbiota–gut–brain axis in adult offspring mice

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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