Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Arsenic has been ranked as the most hazardous substance by U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public concern worldwide owing to widespread existence of arsenic. Multi-omics is revolutionary technique data analysis providing an integrated view bioinformation comprehensively systematically understanding elaborate mechanism diseases. This study aimed at uncovering potential contribution liver-microbiota-gut axis in chronic inorganic exposure-triggered biotoxicity chickens based on multi-omics technologies. Forty Hy-Line W-80 laying hens were chronically exposed sodium arsenite with dose-dependent manner (administered drinking water containing 10, 20, or 30 mg/L arsenic, respectively) 42 d, followed transcriptomics, serum non-targeted metabolome, 16S ribosomal RNA gene sequencing accordingly. intervention induced serious chicken liver dysfunction, especially severe fibrosis, simultaneously altered ileal microbiota populations, impaired intestinal barrier, further drove enterogenous lipopolysaccharides translocation via portal vein circulation aggravating damage. Furtherly, injured disturbed bile acids (BAs) homoeostasis through strongly up-regulating BAs synthesis key rate-limiting enzyme CYP7A1, inducing excessive total accumulation, accompanied massive primary BA—chenodeoxycholic acid. Moreover, concentrations secondary BAs—ursodeoxycholic acid lithocholic markedly repressed, which might involve repressed dehydroxylation Ruminococcaceae Lachnospiraceae families. Abnormal metabolism turn promoted injury, ultimately perpetuating pernicious circle chickens. Notably, obvious depletion abundance four profitable microbiota, Christensenellaceae, Ruminococcaceae, Muribaculaceae, Faecalibacterium, correlated tightly this hepato-intestinal process Our demonstrates that exposure evokes disruption establishes scientific basis evaluating risk environmental pollutant

Язык: Английский

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Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers

The Science of The Total Environment, Год журнала: 2023, Номер 890, С. 164172 - 164172

Опубликована: Май 16, 2023

Язык: Английский

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Combined toxicity of polystyrene microplastics and perfluorobutane sulfonate on mouse liver: Impact on lipid metabolism and gut-liver axis disruption

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117904 - 117904

Опубликована: Фев. 20, 2025

Язык: Английский

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Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation

Tissue and Cell, Год журнала: 2025, Номер 93, С. 102748 - 102748

Опубликована: Янв. 18, 2025

Язык: Английский

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Thiacloprid Exposure Induces Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis in the Liver of Mauremys reevesii

Ecology and Evolution, Год журнала: 2025, Номер 15(2)

Опубликована: Фев. 1, 2025

ABSTRACT Among neonicotinoid insecticides, thiacloprid (THI) is extensively utilized in agricultural practices, which poses a potential toxicity risk to aquatic fauna. Turtles, integral ecosystems, have not yet been comprehensively assessed for their vulnerability THI exposure. In this study, we aimed evaluate the effects of on oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis turtles. We categorized Mauremys reevesii into three groups: control group two experimental groups exposed environmentally relevant (4.5 μg/mL) high (15 mg/mL) concentrations THI, respectively. Transcriptome analysis revealed that genes significantly associated with elimination superoxide radicals, organelle inner membrane functions, peroxiredoxin activity, apoptotic pathways were abundantly expressed high‐concentration group. Notably, exposure led marked increase glutathione peroxidase (GPX) dismutase (SOD) activities, whereas catalase (CAT) activity declined malondialdehyde (MDA) levels rose, indicating presence stress. Moreover, upregulated expression ER marker GRP78. Simultaneously, mRNA pivotal unfolded protein response genes, including AFT6, AFT4, IRE1α, CHOP, XBP1, eIF2α, elevated Furthermore, activated activities caspase‐3, caspase‐8, caspase‐9 enzymes liver tissue. The anti‐apoptotic gene Bcl‐2 was downregulated, pro‐apoptotic Bax caspase‐3 upregulated, leading an hepatic cells following Collectively, our study indicates can induce damage turtles through promotion ERS, apoptosis. These findings gain deeper understanding toxic keystone species thereby improving overall environmental impacts.

Язык: Английский

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Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 230, С. 123154 - 123154

Опубликована: Янв. 5, 2023

Язык: Английский

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Resveratrol Alleviates Liver Fibrosis Induced by Long-Term Inorganic Mercury Exposure through Activating the Sirt1/PGC-1α Signaling Pathway

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(28), С. 15985 - 15997

Опубликована: Июль 3, 2024

Liver disease has become an important risk factor for global health. Resveratrol (Res) is a natural polyphenol which widely found in foods and variety of biological activities. This study investigated the role microbiota-gut-liver axis Res relieving liver fibrosis induced by inorganic mercury exposure. Twenty-eight mice were divided into four groups (n = 7) treated with mercuric chloride and/or 24 weeks, respectively. The results showed that mitigated ileum injury restrained LPS alcohol entering body circulation. Network pharmacological molecular analyses alleviated oxidative stress, metabolism disorders, inflammation, hepatic stellate cell activation liver. In conclusion, alleviates via activating Sirt1/PGC-1α signaling pathway regulating microbial-gut-liver axis, particularly, increasing relative enrichment Bifidobacterium intestinal tract.

Язык: Английский

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Tire-wear particle leachate at environmentally relevant concentrations exert a hepatotoxic impact on the black-spotted frog by disrupting the gut–liver axis

Environmental Chemistry and Ecotoxicology, Год журнала: 2024, Номер 6, С. 380 - 389

Опубликована: Янв. 1, 2024

Язык: Английский

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The role of mitochondrial dynamics imbalance in hexavalent chromium-induced apoptosis and autophagy in rat testis

Chemico-Biological Interactions, Год журнала: 2023, Номер 374, С. 110424 - 110424

Опубликована: Фев. 26, 2023

Язык: Английский

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Flunitrazepam induces neurotoxicity in zebrafish through microbiota-gut-brain axis

The Science of The Total Environment, Год журнала: 2023, Номер 901, С. 165974 - 165974

Опубликована: Авг. 1, 2023

Язык: Английский

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