The Science of The Total Environment, Год журнала: 2024, Номер 955, С. 177076 - 177076
Опубликована: Окт. 30, 2024
Язык: Английский
Environment & Health, Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
2
The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170592 - 170592
Опубликована: Фев. 12, 2024
The expanded uses of bioplastics require understanding the potential health risks associated with their exposure. To address this issue, Drosophila melanogaster as a versatile terrestrial in vivo model was employed, and polylactic acid nanoplastics (PLA-NPLs), proxy for bioplastics, were tested material model. Effects determined larvae exposed 4 days to different concentrations (25, 100, 400 μg/mL) 463.9 ± 129.4 nm PLA-NPLs. Transmission electron microscopy (TEM) scanning microscope (SEM) approaches permitted detection PLA-NPLs midgut lumen larvae, interacting symbiotic bacteria. Enzymatic vacuoles observed carriers, collecting enabling crossing peritrophic membrane, finally internalizing into enterocytes. Although no toxic effects egg-to-adult survival, cell uptake causes cytological disturbances formation large vacuoles. translocation across intestinal barrier demonstrated by presence hemolymph. PLA-NPL exposure triggered damage, oxidative stress, DNA inflammation responses, evaluated via wide set marker genes. Collectively, these structural molecular interferences caused generated high levels stress damage hemocytes larvae. point out need further studies aiming deepen before adopting safe plastic alternative.
Язык: Английский
Процитировано
16
Environmental Chemistry Letters, Год журнала: 2024, Номер 22(3), С. 1185 - 1220
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
12
Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 133972 - 133972
Опубликована: Март 6, 2024
Язык: Английский
Процитировано
10
Environmental Chemistry Letters, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
1
Microbial Biotechnology, Год журнала: 2024, Номер 17(3)
Опубликована: Март 1, 2024
Abstract Global plastic waste accumulation has become omnipresent in public discourse and the focus of scientific research. Ranking as sixth most produced polymer globally, polyurethanes (PU) significantly contribute to environmental pollution due toxicity their building blocks, such diisocyanates. In this study, effects PU on soil microbial communities over 18 months were monitored revealing that it had marginal diversity. However, Streptomyces sp. PU10, isolated from PU‐contaminated soil, proved exceptional degradation a soluble polyester‐PU (Impranil) across range temperatures with 96% 10 g/L 48 h. Proteins involved metabolic changes occurring strain Impranil sole carbon source further investigated employing quantitative proteomics. The proposed mechanism implicated action three enzymes: polyester‐degrading esterase, urethane bond‐degrading amidase an oxidoreductase. Furthermore, proteome data revealed intermediates incorporated into PU10 metabolism via fatty acid pathway subsequently channelled polyketide biosynthesis. Most notably, production tri‐pyrrole undecylprodigiosin was confirmed paving way for establishing upcycling strategies bioactive metabolites using strains.
Язык: Английский
Процитировано
7
Environment International, Год журнала: 2024, Номер 191, С. 108949 - 108949
Опубликована: Авг. 15, 2024
Ageing is a nature process of microplastics that occurrs daily, and human beings are inevitably exposed to aged microplastics. However, systematic understanding ageing status its toxic effect currently still lacking. In this study, plastic cup lids-originated polypropylene (PP) were UV-photoaged until the carbonyl index (CI), canonical indicator for ageing, achieved 0.08, 0.17, 0.22 0.28. The adverse hepatic these PPs (aPPs) was evaluated in Balb/c mice (75 ng/mL water, about 200 particles/day) human-originated liver organoids (LOs, 50 particles/mL, ranged from 5.94 13.15 ng/mL) at low-dose equivalent exposure level. Low-dose PP could induce reductive stress both vitro vivo, by elevating NADH/NAD+ratio CI-dependent manner, together with hepatoxicity (indicated increased AST secretion cytotoxicity), disrupted genes encoding nutrients transporters NADH subunits accompanied restricted ATP supply, declined mitochondrial membrane potential complexI/IV activities, without significant increase MDA levels liver. These changes metabolism, representing circulatory panel increases lactate, triglyceride, Fgf21 levels, decreases pyruvate level, linked body weight gain but elevated contents following aPPs exposure. Additionally, assessing LOs, it found digestion drastically accelerated worsen energy supply upon mitochondria, "scattergun effect" induced formation micro- nano-plastics mixture toward NADH/NAD+imbalance.
Язык: Английский
Процитировано
6
Device, Год журнала: 2025, Номер unknown, С. 100725 - 100725
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Chemosphere, Год журнала: 2024, Номер 368, С. 143713 - 143713
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
The Science of The Total Environment, Год журнала: 2024, Номер 955, С. 177076 - 177076
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
0