Solar thermoplasmonic convection for sustainable removal of microplastics

Solar Energy Materials and Solar Cells, Год журнала: 2025, Номер 282, С. 113416 - 113416

Опубликована: Янв. 11, 2025

Язык: Английский

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Tracing the Footprint of Microplastics: Transport Mechanism, Degradation, and Remediation in Marine Environment

Water Air & Soil Pollution, Год журнала: 2025, Номер 236(2)

Опубликована: Янв. 24, 2025

Язык: Английский

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Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the toxicity of PLA in mice and potential mechanisms. To this end, our vivo vitro experiments demonstrated that after degradation digestive system, significant number PLA-MP-derived nanoparticles could penetrate blood–testis barrier (BTB) localize within spermatogenic microenvironment. Mice exposed to PLA-MPs long time exhibited toxicity, evidenced by decreased sperm concentration motility, increased deformity rates, disrupted sex hormone levels. Further analysis revealed impaired BTB, induced mitochondrial dysfunction testes, triggered oxidative stress through excessive ROS production from mitochondria, leading further testicular damage. Notably, nanoplastics internalized sheath structure sperm, causing dose-dependent impairments function. Transcriptome analyses indicated spermatogenesis inhibiting expression key mRNA involved process. Collectively, findings highlight toxic effect damaging BTB impairing function, which provides insights into toxicological implications microplastics mammalian fertility.

Язык: Английский

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Toxicological effects and mechanisms of renal injury induced by inhalation exposure to airborne nanoplastics

Journal of Hazardous Materials, Год журнала: 2025, Номер 488, С. 137393 - 137393

Опубликована: Янв. 30, 2025

Язык: Английский

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Low dose of micro-/nano-plastics mixture induced cardiac hypertrophy and reductive stress: the liver-heart crosstalk and hepatic-cardiac organoids-on-a-chip

Journal of Hazardous Materials, Год журнала: 2025, Номер 490, С. 137686 - 137686

Опубликована: Фев. 20, 2025

Язык: Английский

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An insight into nitrite-induced reproductive toxicity and the alleviation of injury by selenomethionine through activation of the Keap1/Nrf2 pathway in Procambarus clarkii

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141616 - 141616

Опубликована: Март 3, 2025

Язык: Английский

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Co-Exposure to Polystyrene Microplastics and Bisphenol A Contributes to the Formation of Liver Fibrosis in Mice through Inhibition of the BMAL1/E-Cad Signaling Pathway

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

The food safety risks posed by exposure to polystyrene microplastics (PS-MPs) and bisphenol A (BPA) have become an issue worldwide. However, the toxic effects of PS-MPs BPA coexposure on mammalian liver remain elusive. In this study, we found that synergistic AML12 cells mouse liver. Histopathological staining revealed excessive accumulation extracellular matrix in Co-exposure downregulated Bmal1 E-cad both vitro vivo. Additionally, Bmal1–/– liver-specific mice exhibited significantly reduced levels, with no significant reduction under coexposure. Notably, overexpression BMAL1 CLOCK enhanced luciferase activity driven gene intron region (containing E-box cis-element). These results demonstrated contributed development fibrosis inhibiting BMAL1/E-cad signaling pathway.

Язык: Английский

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The Nrf2-Keap1/ARE signaling pathway in aquatic animals

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142595 - 142595

Опубликована: Март 1, 2025

Язык: Английский

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High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations

Biosensors, Год журнала: 2025, Номер 15(4), С. 242 - 242

Опубликована: Апрель 11, 2025

Brain aging is a complex process regulated by genetic, environmental, and metabolic factors, increasing evidence suggests that environmental pollutants can significantly accelerate this interfering with oxidative stress, neuroinflammation, mitochondrial function-related signaling pathways. Traditional studies have focused on the direct damage of macromolecules (e.g., proteins, DNA), while central role senescence-associated small molecules ROS, PGE2, lactate) in early regulatory mechanisms has been long neglected. In study, we innovatively proposed cascade framework “small molecule imbalance-signaling pathway dysregulation-macromolecule collapse”, which reveals exacerbate dynamics brain through activation NLRP3 inflammatory vesicles inhibition HIF-1α. Meanwhile, to address technical bottleneck spatiotemporal monitoring, paper systematically reviews cutting-edge detection tools such as electrochemical sensors, genetically encoded fluorescent probes antioxidant quantum dots (AQDs). Among them, AQDs show unique advantages real-time monitoring ROS fluctuations intervention virtue their ultra-high specific surface area, controllable modification, free radical scavenging ability. By integrating multimodal techniques mechanism studies, work provides new perspective for analyzing pollutant-induced lays methodological foundation strategies based networks.

Язык: Английский

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Integrative bioinformatics analysis to identify ferroptosis-related genes in non-obstructive azoospermia

Journal of Assisted Reproduction and Genetics, Год журнала: 2024, Номер 41(8), С. 2145 - 2161

Опубликована: Июнь 20, 2024

Язык: Английский

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