Poultry Science,
Год журнала:
2024,
Номер
103(8), С. 103964 - 103964
Опубликована: Июнь 12, 2024
This
study
aimed
to
explore
the
impact
of
dietary
Bacillus
subtilis
fmbj
(BS)
supplementation
on
acute
intestinal
dysfunction
induced
by
lipopolysaccharide
(LPS)
in
broilers.
One
hundred
and
eighty
1-day-old
male
Arbor
Acres
broilers
were
randomly
divided
into
three
treatment
groups,
each
comprising
ten
replicates
6
birds.
On
d
20,
LPS-challenged
(LPS
group
LPS-BS
group)
LPS-unchallenged
(CON
received
intraperitoneal
injections
1
mg/kg
body
weight
LPS
solution
an
equivalent
volume
sterile
saline,
respectively.
Compared
CON
group,
disrupted
(P
<
0.05)
morphology
small
intestine
(jejunum
or
ileum),
exacerbated
serum,
intestinal,
mitochondrial
antioxidant
capacity,
oxidative
damage,
altered
expression
genes
proteins
related
antioxidants,
cell
adhesion,
function
jejunum.
The
exhibited
a
tendency
towards
improvement
morphology,
jejunum
when
compared
group.
In
conclusion,
BS
may
confer
protection
against
LPS-induced
enhancing
activation
SIRT1/PGC1α,
suggesting
its
potential
as
valuable
additive
for
poultry
industry.
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 370 - 370
Опубликована: Март 18, 2024
Lead
(Pb),
a
heavy
metal
environmental
pollutant,
poses
threat
to
the
health
of
humans
and
birds.
Inflammation
is
one
most
common
pathological
phenomena
in
case
illness
poisoning.
However,
underlying
mechanisms
inflammation
remain
unclear.
The
cerebellum
thalamus
are
important
parts
nervous
system.
To
date,
there
have
been
no
reports
Pb
inducing
animal
cerebellums
or
thalami.
Selenium
(Se)
can
relieve
Therefore,
we
aimed
explore
mechanism
by
which
Se
alleviates
toxicity
thalami
chickens
establishing
chicken
or/and
treatment
model.
Our
results
demonstrated
that
exposure
caused
inflammatory
damage
thalami,
evidenced
characteristics
inflammation,
decrease
anti-inflammatory
factors
(interleukin
(IL)-2
interferon-γ
(INF-γ)),
increase
pro-inflammatory
(IL-4,
IL-6,
IL-12β,
IL-17,
nitric
oxide
(NO)).
Moreover,
found
IL-2/IL-17–NO
pathway
took
part
Pb-caused
injury.
above
findings
were
reversed
supplementation
dietary
Se,
meaning
relieved
via
pathway.
In
addition,
an
up-regulated
oxidative
index
malondialdehyde
(MDA)
two
down-regulated
antioxidant
indices
(glutathione
(GSH)
total
capacity
(TAC))
recorded
after
received
stimulation,
indicating
excess
oxidant/antioxidant
imbalance
stress,
stress
mediated
GSH–IL-2
axis.
Interestingly,
inhibited
four
glutathione
peroxidase
(GPx)
family
members
(GPx1,
GPx2,
GPx3,
GPx4),
three
deiodinase
(Dio)
(Dio1,
Dio2,
Dio3),
fifteen
other
selenoproteins
(selenophosphate
synthetase
2
(SPS2),
selenoprotein
(Sel)H,
SelI,
SelK,
SelM,
SelO,
SelP1,
SelPb,
SelS,
SelT,
SelU,
(Sep)n1,
Sepw1,
Sepx1,
Sep15),
suggesting
reduced
resulted
involving
SPS2–GPx1–GSH
supplementation,
as
expected,
changes
mentioned
above,
improved
mitigated
chickens.
For
first
time,
discovered
SPS2–GPx1–GSH–IL-2/IL-17–NO
involved
complex
conclusion,
this
study
Pb-induced
This
offers
novel
insights
into
pollutant-caused
poisoning
provides
theoretical
basis
for
detoxification
effect
against
toxic
pollutants.
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 395 - 395
Опубликована: Март 26, 2024
Central
neurological
disorders
are
significant
contributors
to
morbidity,
mortality,
and
long-term
disability
globally
in
modern
society.
These
encompass
neurodegenerative
diseases,
ischemic
brain
traumatic
injury,
epilepsy,
depression,
more.
The
involved
pathogenesis
is
notably
intricate
diverse.
Ferroptosis
neuroinflammation
play
pivotal
roles
elucidating
the
causes
of
cognitive
impairment
stemming
from
these
diseases.
Given
concurrent
occurrence
ferroptosis
due
metabolic
shifts
such
as
iron
ROS,
well
their
critical
central
nervous
disorders,
investigation
into
co-regulatory
mechanism
has
emerged
a
prominent
area
research.
This
paper
delves
mechanisms
along
with
interrelationship.
It
specifically
emphasizes
core
molecules
within
shared
pathways
governing
neuroinflammation,
including
SIRT1,
Nrf2,
NF-κB,
Cox-2,
iNOS/NO·,
how
different
immune
cells
structures
contribute
dysfunction
through
mechanisms.
Researchers’
findings
suggest
that
mutually
promote
each
other
may
represent
key
factors
progression
disorders.
A
deeper
comprehension
common
pathway
between
cellular
holds
promise
for
improving
symptoms
prognosis
related
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 495 - 516
Опубликована: Фев. 21, 2024
During
skin
aging,
the
degeneration
of
epidermal
stem
cells
(EpiSCs)
leads
to
diminished
wound
healing
capabilities
and
disintegration.
This
study
tackles
this
issue
through
a
comprehensive
analysis
combining
transcriptomics
untargeted
metabolomics,
revealing
age-dependent
alterations
in
