Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms

Nature Nanotechnology, Год журнала: 2024, Номер 19(9), С. 1354 - 1365

Опубликована: Июнь 7, 2024

Язык: Английский

---

Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(5), С. 4186 - 4202

Опубликована: Апрель 30, 2024

As environmental plastic waste degrades, it creates an abundance of diverse microplastic particles. Consequently, microplastics contaminate drinking water and many staple food products, meaning the oral ingestion is important exposure route for human population. Microplastics have long been considered inert, however their ability to promote microbial dysbiosis as well gut inflammation dysfunction suggests they are more noxious than first thought. More alarmingly, there evidence permeating from throughout body, with adverse effects on immune nervous systems. Coupled now-accepted role gut-brain axis in neurodegeneration, these findings support hypothesis that this ubiquitous pollutant contributing rising incidence neurodegenerative diseases, like Alzheimer’s disease Parkinson’s disease. This comprehensive narrative review explores consequences gut-brain-axis by considering current gastrointestinal uptake disruption, activation, translocation neurological effects. now a permanent feature global environment, understanding gut, brain, whole body will facilitate critical further research inform policy changes aimed at reducing any consequences.

Язык: Английский

---

Polystyrene microplastics impair brown and beige adipocyte function via the gut microbiota-adipose tissue crosstalk in high-fat diet mice

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138225 - 138225

Опубликована: Апрель 1, 2025

Язык: Английский

---

The influence of microplastics on hypertension-associated cardiovascular injury via the modulation of gut microbiota

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 125760 - 125760

Опубликована: Янв. 1, 2025

Язык: Английский

---

Microplastic effects on mouse colon in normal and colitis conditions: A literature review

PeerJ, Год журнала: 2025, Номер 13, С. e18880 - e18880

Опубликована: Фев. 10, 2025

Background Taking into account the global spread of microplastic (MP) pollution, problem MP impact on human health is relevant. enters organism predominantly with water and food, mostly detected in large intestine. Therefore, connection between pollution increase colitis an important question. In order to assess toxic pathogenetic effects MP, experimental studies were actively conducted during recent years, mainly laboratory mice. Objectives The aim our review was summarize systematize data effect mice colon under normal conditions role development intestinal diseases. This manuscript could be relevant for ecologists, biologists, physicians dealing problems related anthropogenic environmental changes inflammatory bowel Survey Methodology search based PubMed about original healthy colitis. Results colon, can cause oxidative stress, increased permeability, immune cell infiltration, production proinflammatory factors, decreased mucus production. affects proliferation, apoptosis, differentiation epithelial cells, expression tight junction components glycocalyx, membrane transport, signaling pathways, metabolome, microflora composition. acute chronic colitis, consumption leads a more pronounced pathological process course. Conclusions may one factors contributing humans. However, further research needed.

Язык: Английский

---

Microplastics Accumulation in Fibrotic Intestinal Tissue of Crohn's Disease Patients

Environmental Research, Год журнала: 2025, Номер unknown, С. 121077 - 121077

Опубликована: Фев. 1, 2025

Язык: Английский

---

Organ-Specific Effects of Polystyrene Nanoplastics on Deltamethrin-Induced Toxicity in Mice: Mitigated Hepatorenal Oxidative Damage But Increased Enteric Toxicity

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер 73(9), С. 5092 - 5101

Опубликована: Фев. 24, 2025

This study investigates the combined effects of polystyrene nanoplastics (PS-NPs) and deltamethrin (DEL) on mice, focusing their different impacts among organs. Mice were exposed to PS-NPs and/or DEL for 30 days. Results showed that alleviated DEL-induced oxidative damage in liver kidney by reducing its accumulation due decreased bioaccessibility. Conversely, increased intestine, leading enhanced susceptibility enteric infections caused bacteria, viruses, parasites, as indicated transcriptomic analysis. delayed excretion gastrointestinal motility, evidenced altered neurotransmitter levels, thereby contributing greater intestinal DEL. Moreover, 16S rDNA sequencing revealed tended decrease beneficial bacteria increase pathogenic gut microbiota, further heightening upon coexposure. The findings this shed new light complex health risks associated with coexposure pesticides.

Язык: Английский

---

Doxycycline degradation by Enterobacter cloacae HS-08: A comparative analysis of biodegradation and bio-electrodegradation approaches with toxicity implications

Journal of Environmental Management, Год журнала: 2025, Номер 381, С. 125212 - 125212

Опубликована: Апрель 7, 2025

Язык: Английский

---

Microplastics and Nanoplastics as Environmental Contaminants of Emerging Concern: Potential Hazards for Human Health

Sustainability, Год журнала: 2024, Номер 16(19), С. 8704 - 8704

Опубликована: Окт. 9, 2024

With nearly 40% of the total plastics produced being used for packaging, up to five trillion plastic bags are consumed in world annually. The inadequate disposal waste and its persistence has become a serious challenge/risk environment, health, well-being living creatures, including humans. natural degradation is extremely slow; large pieces may break down into microplastics (MPs) (1 μm–5 mm) or nanoplastics (NPs) (<1000 nm) after protracted physical, chemical, and/or biological degradations. A brief overview transport micro- aquatic, terrestrial, atmospheric environments presented. Details provided on exposure routes these materials their entry humans other biota through ingestion, inhalation, dermal contact. greatest concern cumulative impact heterogeneous secondary MPs NPs planetary human health. Inhaled have been shown affect upper respiratory tract, lower alveoli; prolonged can lead chronic inflammatory changes systemic disease. These also autoimmune diseases health conditions, atherosclerosis malignancy. Sustainable mitigation strategies reduce MPs/NPs include source reduction, material substitution, filtration purification, transformation value-added materials, technological innovations, etc. Multidisciplinary collaborations across fields medicine, public environmental science, economics, policy required help limit detrimental effects widespread environment.

Язык: Английский

---

Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Ноя. 25, 2024

Microplastics (MPs), defined as plastic particles smaller than 5 mm, are increasingly recognized environmental contaminants with potential health risks. These emerge breakdown products of larger plastics and omnipresent in marine, freshwater, terrestrial ecosystems. They primarily composed polymers such polyethylene, polypropylene, polystyrene, additives that enhance their performance. MPs also adsorb harmful chemicals like persistent organic pollutants heavy metals, posing risks to human health. Human exposure occurs mainly through ingestion inhalation, detected food products, water, even the air. have been shown accumulate gastrointestinal tract, disrupting gut microbiome, causing dysbiosis-a imbalance between beneficial bacteria. This disruption has linked various issues, including disorders, systemic inflammation, chronic diseases. Furthermore, gut-brain axis may be affected, neuroinflammatory consequences. As research continues unravel impacts MP exposure, understanding mechanisms accumulation broader implications on is crucial. review highlights effects health, emphasizing impact microbiome. We discuss connections cardiometabolic inflammatory diseases, disorders related Gut-Brain Axis. By synthesizing latest research, this work sheds light silent yet pervasive threat posed by underscores importance further studies understand fully.

Язык: Английский

---