Visible-Light-Responsive Novel Ru(II)-Metallo-Antibiotics with Potential Antibiofilm and Antibacterial Activity

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28118 - 28133

Опубликована: Май 24, 2024

Growing challenges with antibiotic resistance pose immense in combating microbial infections and biofilm prevention on medical devices. Lately, antibacterial photodynamic therapy (aPDT) is now emerging as an alternative to overcome this problem. Herein, we synthesized characterized four Ru(II)-complexes, viz., [Ru(ph-tpy)(bpy)Cl]PF6 (Ru1), [Ru(ph-tpy)(dpq)Cl]PF6 (Ru2), [Ru(ph-tpy)(dppz)Cl]PF6 (Ru3), [Ru(ph-tpy)(dppn)Cl]PF6 (Ru4) (where 4′-phenyl-2,2′:6′,2″-terpyridine = ph-tpy; 2,2′-bipyridine bpy; dipyrido[3,2-f:2′,3′-h]quinoxaline dpq; dipyrido[3,2-a:2′,3′-c]phenazine dppz; Benzo[I]dipyrido[3,2-a:2′,3′-c]phenazine dppn), among which Ru2–Ru4 are novel. Octahedral geometry of the complexes a RuN5Cl core was evident from crystal structure Ru2. Ru1–Ru4 showed MLCT absorption band 450–600 nm region, useful for aPDT performances. Further, optimum triplet excited state energy excellent photostability made them good photosensitizers aPDT. demonstrated enhanced antimicrobial activity visible-light exposure (400–700 nm, 10 J cm–2), confirmed using different assays. Mechanistic studies revealed that inhibition bacterial growth due generation oxidative stress (via NADH oxidation ROS generation) upon treatment Ru2–Ru4, resulting destruction wall. Ru2 performed best killing performance against both Gram-negative (Escherichia coli) Gram-positive (Bacillus subtilis) bacteria when exposed light. coated polydimethylsiloxane (PDMS) disk, long-term reusability durable antibiofilm properties. Molecular docking efficient interaction FabH (regulates fatty acid biosynthesis E. PgaB (gives structural stability helps formation coli), probable downregulation. In vivo healthy Wistar rats biocompatibility This study shows these lead (Ru2–Ru4) can be used potent agents low concentrations toward eradication (PDT).

Язык: Английский

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Red and NIR light-triggered enhancement of anticancer and antibacterial activities of dinuclear Co(ii)-catecholate complexes

Dalton Transactions, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Photoactive complexes of bioessential 3d metals, activable within the phototherapeutic window (650-900 nm), have gained widespread interest due to their therapeutic potential. Herein, we report synthesis, characterization, and light-enhanced anticancer antibacterial properties four new dinuclear Co(II) complexes: [Co(phen)(cat)]2 (Co-1), [Co(dppz)(cat)]2 (Co-2), [Co(phen)(esc)]2 (Co-3), [Co(dppz)(esc)]2 (Co-4). In these complexes, phen (1,10-phenanthroline) dppz (dipyrido[3,2-a:2',3'-c]phenazine) act as neutral N,N-donor ligands, while cat2- esc2- serve O,O-donor catecholate ligands derived from catechol (1,2-dihydroxybenzene) esculetin (6,7-dihydroxy coumarin). Their high-spin paramagnetic nature dimeric identity in solution were confirmed by magnetic susceptibility, UV-visible, emission, mass spectral data. Co-1-Co-4 exhibited an absorption band 600-850 nm range, originating a charge transfer transition. The electrically demonstrated sufficient stability both dark under irradiated conditions. Co-2 Co-4 notable toxicity towards A549 lung carcinoma cells, with potency increasing significantly brief (5 min) exposure 660 (red) 808 (NIR) laser light (IC50 ∼ 8.9 14.9 μM). Notably, normal NIH-3T3 fibroblast cells was minimal. Cellular assays highlighted that induced cell death followed apoptotic pathway, primarily mitochondrial damage. also significant against Gram-(+) S. aureus Gram-(-) P. aeruginosa, effectiveness enhanced upon irradiation (MIC 15-142 increase efficacies attributed generation cytotoxic singlet oxygen (1O2) species red/NIR exposure. NIR produced more pronounced effects compared nm. This study is first on cobalt exhibiting red light-triggered enhancement activities, illuminating path for development long-wavelength absorbing efficacy.

Язык: Английский

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Ruthenium (II) polypyridyl complexes as two-photon absorbers and sensitizers: Design, structure-properties relationships and applications

Coordination Chemistry Reviews, Год журнала: 2024, Номер 518, С. 216050 - 216050

Опубликована: Июль 7, 2024

This review addresses recent advancements in understanding multiphoton excitation of ruthenium polypyridyl complexes, highlighting their relevance the fields molecular materials and bio-medical applications. Emphasis is placed on two-photon absorption excited photoluminescence for which these complexes meet several requirements as sensitizers. Alongside appealing one-photon properties, are photostable under can exhibit noticeable cross-sections near-infrared (NIR) region. Moreover, presence atom favors spin–orbit coupling, facilitating rapid efficient population triplet states, thereby extending emission lifetimes, or uncaging reactions, according to structural characteristics. Indeed, offer great versatility terms functionalization, enabling property fine-tuning. also outlines forthcoming challenges prospects field through representative examples area materials, bio-imaging phototherapies.

Язык: Английский

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Emerging Trends in Dissolving-Microneedle Technology for Antimicrobial Skin-Infection Therapies

Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1188 - 1188

Опубликована: Сен. 8, 2024

Skin and soft-tissue infections require significant consideration because of their prolonged treatment duration propensity to rapidly progress, resulting in severe complications. The primary challenge stems from the involvement drug-resistant microorganisms that can form impermeable biofilms, as well possibility infection extending deep into tissues, thereby complicating drug delivery. Dissolving microneedle patches are an innovative transdermal drug-delivery system effectively enhances penetration through stratum corneum barrier, increasing concentration at site infection. They offer highly efficient, safe, patient-friendly alternatives conventional topical formulations. This comprehensive review focuses on recent advances emerging trends dissolving-microneedle technology for antimicrobial skin-infection therapy. Conventional antibiotic microneedles compared with those based agents, such quorum-sensing inhibitors, peptides, antimicrobial-matrix materials. also highlights potential incorporating chemodynamic, nanoenzyme antimicrobial, photodynamic, photothermal antibacterial therapies. explores advantages various therapies emphasizes combined application improve efficacy microneedles. Finally, this analyzes druggability different discusses possible future developments.

Язык: Английский

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Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 29, 2025

The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Photodynamic transition metal complexes leveraging unique properties metals enhance aPDT activity are next-generation PS. review provides an overview metal-based PS Based on structures, these metal-PS could be mainly classified as metal-tetrapyrrole derivatives, ruthenium complexes, iridium and zinc complexes. based other such silver, cobalt, rhenium also presented. Finally, we summarize advantages shortcomings metal- PS, conclude some critical aspects impacting their performances give perspective future development.

Язык: Английский

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X-Ray-Sensitive Drug Delivery Model Based on Citrate-Modified Tb-Doped Hydroxyapatite Nanoparticles for Photopharmacology and Photodynamic Therapy

Опубликована: Янв. 1, 2025

Язык: Английский

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Recent Developments in Antimicrobial and Antiviral Agents Based on Natural/Synthetic Polymers and Dendrimers: Design and Therapeutic Applications

Macromolecular Chemistry and Physics, Год журнала: 2024, Номер 225(17)

Опубликована: Май 28, 2024

Abstract This review article explores the recent innovations in field of antimicrobial and antiviral macromolecules. With rising challenge antibiotic resistance, as well overuse antibiotics, there is a growing demand for efficient solutions to combat microbial viral infections. The development new effective agents highlighted. designed give comprehensive view literature focusing on few examples combating infections each section. A brief description naturally occurring organic‐based materials that exhibit and/or activities presented, polysaccharides, peptides, proteins. Synthetic are divided into subsections including polymers, dendrimers, nanomaterials. synthesis applications inorganic such polyphosphazenes polysiloxanes, tin‐, germanium‐ gallium‐based emphasized this review. Organometallic macromolecules also described, their examined. Overall, provides overview advancements design macromolecules, offering valuable insights potential biomedical research drug‐resistant microorganisms viruses.

Язык: Английский

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Preparation of MPN@Zein-PpIX Membrane and Its Antibacterial Properties

ACS Omega, Год журнала: 2024, Номер 9(27), С. 29274 - 29281

Опубликована: Июнь 27, 2024

For antibacterial purposes, a photothermal and photodynamic membrane was prepared through electrospinning. We used zein as the substrate introduced Protoporphyrin IX (PpIX) into protein structure. Then, we electrospinning technology to weave modified fiber finally metallic polyphenol network (MPN) coating on surface form final membrane: MPN@Zein-PpIX. investigated properties of assessed its activity with in vitro agar plate counting methods. The MPN@Zein-PpIX exhibited good singlet oxygen generation excellent conversion. Additionally, it showed capacity vitro, owing combination properties. Our research provides simple approach prepare multifunctional ability. technique anchor PpIX onto produce (Zein-PpIX) that can be adhered situ improve biocompatibility PpIX, MPN makes more hydrophilic accessible adhere biological tissues. provided new ideas for combining PDT PTT, had great potential use application field.

Язык: Английский

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Trinuclear ruthenium(II) polypyridyl complexes: Evaluation as photosensitizers for enhanced cervical cancer treatment

Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 256, С. 112545 - 112545

Опубликована: Март 26, 2024

Trinuclear ruthenium(II) polypyridyl complexes anchored to benzimidazole-triazine / trisamine scaffolds were investigated as photosensitizers for photodynamic therapy. The trinuclear noted produce a significant amount of singlet oxygen in both DMF and aqueous media, are photostable show appreciable emission quantum yields (ɸ

Язык: Английский

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Unveiling photoinduced electron transfer in cobalt(iii)-R-pyridine complexes anchored to anatase nanocrystals: photoluminescence and magnetic studies

RSC Advances, Год журнала: 2024, Номер 14(24), С. 17218 - 17233

Опубликована: Янв. 1, 2024

This article demonstrates the synthesis of mixed ligand complexes cis -[Co(tn) 2 (Rpy)Br]Br via a mechanochemical approach. Their ferromagnetic properties and efficient electron transfer to Co( iii ) using TiO under UV light are confirmed.

Язык: Английский

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