Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections

Pathogens, Год журнала: 2023, Номер 12(2), С. 293 - 293

Опубликована: Фев. 10, 2023

Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such have been frequently reported worldwide currently gaining clinical research relevance owing resistant character, representing bottleneck treating affected people. Resistant fungi an emergent public health threat. The upsurge such pathogens has led new toward unraveling the destructive potential evoked by these species. Some fungi—grouped into Candida, Aspergillus, Cryptococcus—are causative agents severe systemic infections. They associated with high mortality rates recently described as sources coinfection COVID-hospitalized patients. Despite efforts elucidate challenges colonization, dissemination, infection severity, immunopathogenesis fungal diseases remains pivotal characteristic burden elimination. struggle between immune system physiological strategies maintain cellular viability is complex. In this brief review, we highlight drug resistance phenotypes significance, taking consideration physiopathology how scientific community could orchestrate avoid dissemination deaths.

Язык: Английский

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Pathogenesis and Pathology of COVID-Associated Mucormycosis: What Is New and Why

Current Fungal Infection Reports, Год журнала: 2022, Номер 16(4), С. 206 - 220

Опубликована: Сен. 29, 2022

Язык: Английский

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A Review of Hyperglycemia in COVID-19

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Апрель 12, 2023

Diabetes mellitus (DM) is one of the most common chronic metabolic disorders worldwide, which increases risk and opportunistic infections. Following coronavirus disease 2019 (COVID-19) pandemic, a higher incidence rate, more severe forms disease, exacerbation hyperglycemia its complications have been observed in patients with DM. Moreover, stress-induced has many hospitalized nondiabetic after contracting COVID-19. Hyperglycemia worsens prognosis both diabetic patients. In this study, mechanism new-onset or hyperglycemia, effect treatments used for COVID-19 on importance appropriate method blood glucose (blood sugar (BS)) control during possible fate recovery from to some extent expressed.

Язык: Английский

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Epidemiology, pathogenesis, clinical characteristics, and treatment of mucormycosis: a review

Annals of Medicine, Год журнала: 2024, Номер 56(1)

Опубликована: Сен. 2, 2024

Aim This review aims to summarize the epidemiology, etiology, pathogenesis, clinical manifestations, and current diagnostic therapeutic approaches for mucormycosis. The goal is improve understanding of mucormycosis promote early diagnosis treatment reduce mortality.

Язык: Английский

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Post-COVID-19 Fungal Infection in the Aged Population

Vaccines, Год журнала: 2023, Номер 11(3), С. 555 - 555

Опубликована: Фев. 27, 2023

Coronavirus disease 2019 (COVID-19) infection is currently a great cause of concern for the healthcare sector around globe. SARS-CoV-2 an RNA virus that causes serious associated with numerous adverse effects and multiple complications different organs systems during its pathogenic cycle in humans. Individuals affected by COVID-19, especially elderly populations immunocompromised people, are greatly vulnerable to opportunistic fungal pathogens. Aspergillosis, invasive candidiasis, mucormycosis widespread coinfections COVID-19 patients. Other infections rare but exhibiting increased incidence current scenario include caused Pneumocystis jirovecii, Histoplasma sp., Cryptococcus etc. By producing virulent spores, these pathogens increase severity morbidity fatality rates patients globally. These generally occur recovering from infection, resulting rehospitalization. Older individuals at higher risk developing infections. This review focuses on understanding prevalent patients, people. We have also highlighted important preventive methods, diagnostic approaches, prophylactic measures

Язык: Английский

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Mucormycosis, Past and Present: A Comprehensive Review

Future Microbiology, Год журнала: 2023, Номер 18(3), С. 217 - 234

Опубликована: Фев. 1, 2023

Mucormycosis is an emerging opportunistic angioinvasive fungal infection. Predisposing factors such as diabetes, neutropenia, long-term corticosteroid therapy, solid organ transplantation and immunosuppression contribute to its occurrence. This disease was not of significant concern prior the COVID-19 pandemic, but gained prominence due infections in patients. needs special attention coordinated efforts scientific community medical professionals reduce morbidity mortality. Here we present overview epidemiology prevalence mucormycosis pre- post-COVID-19 eras, that contributed abrupt increase COVID-19-associated (CAM), actions taken by regulatory agencies (including Code Mucor CAM registry), existing diagnostic tools management strategies.

Язык: Английский

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Mucormycosis: A hidden mystery of fungal infection, possible diagnosis, treatment and development of new therapeutic agents

European Journal of Medicinal Chemistry, Год журнала: 2022, Номер 246, С. 115010 - 115010

Опубликована: Дек. 10, 2022

Язык: Английский

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COVID-19-associated fungal infections in Iran: A systematic review

PLoS ONE, Год журнала: 2022, Номер 17(7), С. e0271333 - e0271333

Опубликована: Июль 11, 2022

Objectives This systematic review aims to summarize the mycological and clinical features of COVID-19-associated fungal infections (CAFIs) in Iran. Methods PubMed, Web Science, Scopus, Cochrane Library, SID, Magiran, IranDoc, Google Scholar were searched for Persian English articles published from January 1, 2020, November 5, 2021, using a search strategy. Studies on Iranian patients suffering CAFIs included review. Results Twenty-two studies comprising 169 retrieved. Reported candidiasis (85, 50.30%), mucormycosis (35, 20.71%), aspergillosis (29, 17.16%), fusariosis (6, 3.55%), three cases caused by rare pathogens (Rhodotorula mucilaginosa , Diaporthe foeniculina Sarocladium kiliense ) 11 (6.51%) uncharacterized mold infections. The most common underlying diseases diabetes (67/168, 39.88%), cardiovascular (55/168, 32.74%), hypertension (43/168, 25.59%). use antibiotics (111/124, 89.52%), corticosteroids (93/132, 70.44%), mechanical ventilation (66, 51.16%) predisposing factors. Totally, 72 (50.35%) 143 with died (data not available 26 patients). Conclusion Fungal are evident be complication COVID-19 Iran; thus, clinicians should consider them as differential diagnosis, especially comorbidities previous antibiotic or corticosteroid use.

Язык: Английский

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Rhino-orbital-cerebral mucormycosis caused by Rhizopus arrhizus diagnosis via metagenomics next-generation sequencing: a case report

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Июль 16, 2024

Rhino-orbital-cerebral mucormycosis (ROCM) is a rare, invasive, and fatal fungal disease that often easily misdiagnosed in the early stages due to lack of specific clinical manifestations adequate auxiliary examinations. Early diagnosis timely therapy are essential for successful treatment. In this report, we presented 46-year-old man with diabetes who experienced gradual vision loss, right ptosis, swelling, headaches progressively worsened death within 4 days after admission. It was finally confirmed as Rhizopus arrhizus infection by metagenomics next-generation sequencing (mNGS). Our report has proved mNGS testing should be strongly recommended highly suspected patients.

Язык: Английский

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Mucormycosis an added burden to Covid-19 Patients: An in-depth systematic review

Journal of Infection and Public Health, Год журнала: 2022, Номер 15(11), С. 1299 - 1314

Опубликована: Окт. 14, 2022

As of 25th July, 2022, global Disease burden 575,430,244 confirmed cases and over 6,403,511 deaths have been attributed to coronavirus disease 2019 (COVID-19). Co-infections/secondary infections continue plague patients around the world as result co-morbidities like diabetes mellitus, biochemical changes caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) especially significant elevation in free iron levels, immune suppression SARS-CoV-2, indiscriminate use systemic corticosteroids for treatment severe COVID-19 disease. In such circumstances, opportunistic fungal pose challenge therapy with other co-morbidities. Although COVID-19-associated Mucormycosis (CAM) has widely recognized, currently extensive research is being conducted on mucormycosis. It agreed that undergoing corticosteroid are highly susceptible CAM, henceforth high index screening intensive care management need an hour order favorable outcomes these patients. Diagnosis often delayed eventually progresses quickly which poses added clinician increases patient load critical units hospitals. A vast perusal literature indicated mellitus those might be vulnerable develop present work, case series three presented at Chest Hospital Srinagar, Jammu Kashmir infected CAM described their epidemiological data supplementary section. All were found affected co-morbidity Diabetes Mellitus (DM) under therapy. Furthermore, given death rate linked mucormycosis growing understanding diseases significance, systematic review discussed we attempted discuss emerging related aspects

Язык: Английский

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