Trajectories Of Persisting Covid-19 Symptoms Up To 24 Months After Acute Infection: Findings From The Predi-Covid Cohort Study DOI Creative Commons
Aurélie Fischer, Lu Zhang, Abir Elbéji

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 7, 2024

Abstract Introduction : Long COVID is a multisystemic, fluctuating condition inducing high burden on affected people. Despite the existence of some guidelines, its management remains complicated. We aimed to demonstrate that evolution follows different trajectories from initial infection until 24 months after and identify determinants these trajectories. Methods Study participants Predi-COVID cohort included between May 2020 September 2021 were digitally followed their acute SARS-CoV-2 maximum months. Data 10 common symptoms collected at study inclusion, 12, 15, used create total symptom score. Impact quality life (sleep, respiratory life, anxiety, stress, fatigue) was assessed month using standardized questionnaires ad-hoc questions. Latent classes mixed models score individual Results 555 with least 2 time points available during follow-up. identified trajectories: T1 “Mild symptoms, fast resolution” (N = 376; 67.7%), T2 “Elevated persisting symptoms” 179; 32.3%). Symptom severity worse in than (high fatigue level: 64.8% vs 19.5%, altered life: 42.6% 4.6%, anxiety: 24.1% stress: 57.4% 35.6%, bad sleep: 75.9% 51.1%). Fatigue pain-related frequencies increased remained elevated Women, body mass index, diabetes, chronic medications associated T2. Conclusion A third our population trajectory, presenting up infection, significant impact life. This work underlined urgent need better individuals most vulnerable long-term complications develop tailored interventions for them.

Язык: Английский

Global Prevalence of Long COVID, its Subtypes and Risk factors: An Updated Systematic Review and Meta-Analysis DOI Creative Commons

Yiren Hou,

Tian Gu,

Zheng Ni

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations geographical regions is necessary for informed public health recommendations healthcare delivery. The primary objective this systematic review to evaluate subtypes symptoms in individuals with confirmed COVID-19 diagnosis, while secondary assess factors same population. Studies on published from July 5, 2021, May 29, 2024, searched PubMed, Embase, Web Science were used review. Supplemental updates original search period made. There four inclusion criteria: (1) human study population diagnosis; (2) appropriate index diagnosis date; (3) outcome must include either prevalence, duration, or COVID; (4) time at least two months after date. exclusion criteria were: non-human population; case studies reviews; imaging, molecular, and/or cellular testing as results; specific populations such workers, residents nursing homes, those living long-term care facilities; that did not meet sample size threshold needed estimate overall margin error 0.05. Two screeners independently performed screenings data extraction, decision conflicts collectively resolved. pooled using a random-effects meta-analysis framework DerSimonian-Laird inverse variance weighted estimator. estimand (target parameter interest) was among diagnoses, effect sizes corresponding ten common A total 442 included mega-systematic review, 429 meta-analyzed various endpoints, avoiding duplicate estimates study. Of studies, 17.9% have high bias. Heterogeneity evident where I 2 statistic nearly 100% prevalence. Global estimated 36% positive (95% confidence interval [CI] 33%-40%) 144 studies. Geographical variation observed COVID: Asia 35% CI 25%-46%), Europe 39% 31%-48%), North America 30% 24%-38%), South 51% 35%-66%). Stratifying by longer periods 1 years (47% [95% 37%-57%]) compared times less than year (35% 31%-39%]) had overlapping therefore statistically distinguishable. Top five most prevalent cases respiratory 20% 14%-28%) 31 general fatigue 18%-23%) 121 psychological 18% 11%-28%) 10 neurological 16% 8%-30%) 23 dermatological 12% 8%-17%) symptom based memory problems 11% 7%-19%) 12 three strongest being unvaccinated COVID-19, pre-existing comorbidity, female sex. Individuals any these higher odds having ratios 2.34 1.49-3.67) 6 1.59 1.28-1.97) 13 1.55 1.25-1.92) 22 respectively. This shows globally highly varying estimates. persists over extended follow-up, burden post-infection. Our findings highlight continuing challenge worldwide. heterogeneity argues need carefully designed representative world. Question: What are patterns what COVID?Results: Meta-analysis 2021-2024 individuals. Variations showed highest CI: 35%-66%), does seem diminish (less year: 35%, 95% 31%-39% vs. years: 47%, 37%-57%). eight major (respiratory), (general fatigue), (psychological), (neurological), (dermatological), 10% (cardiovascular), 9% (musculoskeletal) 5% (gastrointestinal).Meaning: Quantitative evidence persistent globally, significant post-infection, underscoring accurate standardized diagnostic tests biomarkers COVID, better understanding physiology condition, treatment, potential needs workforce participation. wide range call samples well-designed

Язык: Английский

Процитировано

3
2024 Update of the RECOVER-Adult Long COVID Research Index DOI
Linda N. Geng,

Kristine M. Erlandson,

Mady Hornig

и другие.

JAMA, Год журнала: 2024, Номер unknown

Опубликована: Дек. 18, 2024

Importance Classification of persons with long COVID (LC) or post–COVID-19 condition must encompass the complexity and heterogeneity condition. Iterative refinement classification index for research is needed to incorporate newly available data as field rapidly evolves. Objective To update 2023 adults LC using additional participant from Researching Enhance Recovery (RECOVER-Adult) study an expanded symptom list based on input patient communities. Design, Setting, Participants Prospective, observational cohort including 18 years older without known prior SARS-CoV-2 infection who were enrolled at 83 sites in US Puerto Rico. Included participants had least 1 visit taking place 4.5 months after first later, not within 30 days a reinfection. The visits took between October 2021 March 2024. Exposure infection. Main Outcomes Measures Presence participant-reported symptoms. Results A total 13 647 (11 743 1904 infection; median age, 45 [IQR, 34-69 years]; 73% female) included. Using absolute shrinkage selection operator analysis regression approach model, symptoms contributing updated 2024 included postexertional malaise, fatigue, brain fog, dizziness, palpitations, change smell taste, thirst, chronic cough, chest pain, shortness breath, sleep apnea. For index, optimal threshold identify highly symptomatic was score 11 greater. classified 20% 4% those having likely (vs 21% 5%, respectively, index) 39% possible LC, which new category model. Cluster identified 5 subtypes that tracked quality-of-life measures. Conclusions Relevance builds help researchers classify its subtypes. Continued future will be understanding

Язык: Английский

Процитировано

6
The impact of long COVID on heart rate variability: a cross-sectional study DOI Creative Commons

Minyu Qin,

Kwan Lee, Seok‐Ju Yoo

и другие.

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 24, 2025

Long-term COVID-19 (LC), which may affect the autonomic nervous system (ANS), is term for symptoms that some patients had an additional month after contracting virus. Therefore, during LC phase, ANS status was evaluated in with mild-to-moderate using heart rate variability (HRV), a measurement of function. A cross-sectional research 173 participants - both positive and negative – conducted. Based on self-reports, were classified as to whether they or not. 5-minute ECG recorder data detection response report used measure ANS. There notable age differences across groups (p = 0.034). Patients under 25 years lower HRV categorized very-low-frequency (VLF) domain 0.012). Compared group without LC, higher number people aberrant neuroactivity 0.048). Mild-to-moderate young middle develop dysfunction one infection.

Язык: Английский

Процитировано

0
Brain 18F-FDG-PET abnormalities and their associations with neuropsychological assessment in initially hospitalized patients with post-COVID-19 conditions: a prospective and longitudinal study DOI
Sébastien Heyer, Mylène Meyer, Gabriela Hossu

и другие.

European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

Процитировано

0
Trajectories of persisting Covid- 19 symptoms up to 24 months after acute infection: findings from the Predi-Covid cohort study DOI Creative Commons
Aurélie Fischer, Lu Zhang, Abir Elbéji

и другие.

BMC Infectious Diseases, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 25, 2025

Abstract Introduction Long COVID is a multisystemic, fluctuating condition inducing high burden on affected people. Despite the existence of some guidelines, its management remains complicated. We aimed to demonstrate that symptoms after COVID-19 infection evolve following different trajectories from initial until 24 months after, identify determinants these trajectories, and quality life people in trajectories. Methods Study participants Predi-COVID cohort were digitally followed their acute SARS-CoV-2 maximum months. Data 10 common collected at study inclusion, 12, 15, awere used create total symptom score. Impact was assessed month using standardized questionnaires ad-hoc questions. Latent classes mixed models score individual Results included 555 with least 2 time points available during follow-up (Baseline one M12, M15 or M24 questionnaires). identified trajectories: T1 “Mild symptoms, fast resolution” ( N = 376; 67.7%), T2 “Elevated persisting symptoms” 179; 32.3%). The main being were: older age (OR 1.86; p 0.003), be woman 1.81; 0.001)), elevated BMI 3.97; < 0.001), presence multi comorbidities 2.67; 0.005). Symptoms impacted more than (high fatigue level: 64.8% vs 19.5%, altered respiratory life: 42.6% 4.6%, anxiety: 24.1% stress: 57.4% 35.6%, bad sleep: 75.9% 51.1%). Conclusion A third our population trajectory, presenting frequencies up infection, significant impact life. This work underlined urgent need better individuals most vulnerable long-term complications develop tailored interventions for them. Trial registration Clinicaltrials.gov NCT04380987 (date registration: 2020–05-07).

Язык: Английский

Процитировано

0
Tackling persistent neurological symptoms in patients following acute COVID-19 infection: an update of the literature DOI Creative Commons
Eder Cáceres, Afshin A. Divani, André Emilio Viñán Garcés

и другие.

Expert Review of Neurotherapeutics, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Дек. 23, 2024

Introduction The COVID-19 pandemic has taught myriad lessons and left several questions we are yet to comprehend. Initially, the scientific community was concerned with management of acute disease immunization. Once peak receded, it became clear that a proportion patients were far from fully recovered. Researchers started recognize those persisting symptoms as new entity termed 'Long COVID,' where neurological evident have major impact on quality life.

Язык: Английский

Процитировано

3
Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry DOI
Maurizio Leone, Raimund Helbok, Elisa Bianchi

и другие.

Journal of Neurology, Год журнала: 2024, Номер 271(6), С. 3153 - 3168

Опубликована: Март 4, 2024

Язык: Английский

Процитировано

2
Management of patients with neurological diseases considering post‐pandemic coronavirus disease 2019 (COVID‐19) related risks and dangers — An updated European Academy of Neurology consensus statement DOI Creative Commons
Saša R. Filipović, Şerefnur Öztürk, Dániel Bereczki

и другие.

European Journal of Neurology, Год журнала: 2024, Номер 31(10)

Опубликована: Авг. 1, 2024

In October 2020, the European Academy of Neurology (EAN) consensus statement for management patients with neurological diseases during coronavirus disease 2019 (COVID-19) pandemic was published. Due to important changes and developments that have happened since then, need has arisen critically reassess original recommendations address new challenges.

Язык: Английский

Процитировано

2
The National Institutes of Health COVID-19 Neuro Databank/Biobank: Creation and Evolution DOI Creative Commons
Sharon B. Meropol,

C Norris,

Jennifer Frontera

и другие.

Neuroepidemiology, Год журнала: 2024, Номер unknown, С. 1 - 13

Опубликована: Июнь 26, 2024

<b><i>Introduction:</i></b> Diverse neurological conditions are reported associated with the SARS-CoV-2 virus; symptoms most common to persist after resolution of acute infection, affecting 20% patients 6 months illness. The COVID-19 Neuro Databank (NeuroCOVID) was created overcome limitations siloed small local cohorts collect detailed, curated, and harmonized de-identified data from a large diverse cohort adults new or worsened illness, as scientific resource. <b><i>Methods:</i></b> A Steering Committee including US international experts meets quarterly provide guidance. Initial study sites were recruited include wide geographic distribution; academic non-academic sites; urban non-urban locations; different ages, disease severity, comorbidities seen by variety clinical specialists. NeuroCOVID REDCap database developed, incorporating input professional guidelines, existing elements, subject matter experts. eligible is identified at each site; inclusion criteria are: condition infection confirmed testing. De-identified abstracted patients’ medical records, using standardized elements five case report forms. carefully enhanced in response feedback site investigators evolving interest post-acute their timing. Additional added, focusing on diversity populations not already described published literature. By early 2024, included over 2,700 patient 16 5 sites. Data being shared community compliance NIH requirements. program has been invited share forms National Library Medicine an ongoing resource for community. <b><i>Conclusion:</i></b> unique valuable source comprehensive population. Initiated pandemic, collection responsive interests. will continue contribute efforts characterize treat this challenging illness its consequences.

Язык: Английский

Процитировано

1
High Somatization Rates, Frequent Spontaneous Recovery, and a Lack of Organic Biomarkers in Post‐Covid‐19 Condition DOI Creative Commons
Anna R. Tröscher,

Patrick Gebetsroither,

Marc Rindler

и другие.

Brain and Behavior, Год журнала: 2024, Номер 14(10)

Опубликована: Окт. 1, 2024

Many patients report neuropsychiatric symptoms after SARS-CoV-2 infection. Data on prevalence of post-COVID-19 condition (PCC) vary due to the lack specific diagnostic criteria, unspecific symptoms, and reliable biomarkers.

Язык: Английский

Процитировано

1