Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 7, 2023
Human
monkeypox
(mpox)
has
recently
become
a
global
public
health
emergency;
however,
assays
that
detect
mpox
infection
are
not
widely
available,
largely
due
to
cross-reactivity
within
the
Orthopoxvirus
genus.
Immunoassay
development
was
confined
researchers
who
focus
on
biothreats
and
endemic
areas
(Central
West
Africa)
until
2022
outbreak.
As
noted
in
COVID-19
pandemic,
antigen
detection
assays,
integrated
with
molecular
necessary
help
curb
spread
of
disease.
Antigen-detecting
immunoassays
offer
advantage
providing
results
ranging
from
min
h
lateral
flow
formats;
they
can
be
deployed
for
point-of-care,
home,
or
field
use.
This
study
reports
an
mpox-specific
immunoassay
developed
multiplexed,
magnetic-bead-based
platform
utilizing
reagents
all
research
sectors
(commercial,
academic,
governmental).
Two
semi-quantitative
were
parallel
standardized
infectious
virus
(MPXV)
cell
culture
fluid
MPXV-positive
non-human
primate
(NHP)
sera
samples.
These
could
viral
antigens
serum,
highly
specific
toward
MPXV
as
compared
other
orthopoxviruses
(vaccinia
virus,
cowpox
camelpox
virus),
exhibited
correlation
quantitative
PCR
NHP
study.
Access
toolbox
will
key
identifying
cases
ensuring
proper
treatment,
is
currently
traveler.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(8), С. 2234 - 2234
Опубликована: Апрель 12, 2024
Mpox,
caused
by
viruses
of
the
genus
Orthopoxvirus,
is
an
emerging
threat
to
human
and
animal
health.
With
increasing
urbanization
more
frequent
interaction
between
humans
wild
animals,
risk
Mpox
transmission
has
increased
significantly.
This
review
aims
examine
in
depth
epidemiology,
pathogenesis,
diagnosis
with
a
special
focus
on
recent
discoveries
advances
understanding
disease.
Molecular
mechanisms
involved
viral
replication
will
be
examined,
as
well
factors
associated
interspecific
spread
disease
populations.
Currently
available
diagnostic
methods
also
discussed,
critical
analysis
their
limitations
possible
future
directions
for
improving
accuracy
timeliness
diagnosis.
Finally,
this
explore
public
health
implications
emphasizing
importance
epidemiological
surveillance,
vaccination,
emergency
preparedness
prevent
manage
outbreaks.
Understanding
epidemiology
control
strategies
protecting
communities
mitigating
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Май 28, 2024
Monkeypox
(mpox)
is
an
infectious
disease
caused
by
the
mpox
virus
and
can
potentially
lead
to
fatal
outcomes.
It
resembles
infections
viruses
from
other
families,
challenging
identification.
The
pathogenesis,
transmission,
clinical
manifestations
of
Orthopoxvirus
species
are
similar
due
their
closely
related
genetic
material.
This
review
provides
a
comprehensive
discussion
roles
various
proteins,
including
extracellular
enveloped
(EEV),
intracellular
mature
(IMV),
profilin-like
proteins
mpox.
also
highlights
recent
diagnostic
techniques
based
on
these
detect
this
infection
rapidly.
The Microbe,
Год журнала:
2024,
Номер
4, С. 100141 - 100141
Опубликована: Авг. 17, 2024
Monkeypox,
now
named
mpox,
has
emerged
as
a
significant
public
threat,
evidenced
by
the
2022
outbreak
affecting
over
seventy
countries
globally.
This
infectious
disease
presents
debilitating
symptoms,
including
painful
skin
rashes,
mucosal
lesions,
enlarged
lymph
nodes,
and
fever.
The
situation
intensifies
with
concerns
about
novel
transmission
route,
specifically
through
sexual
contact,
evolution
of
more
transmissible
strains.
Complicating
matters
further
is
documented
spillback
mpox
from
humans
to
animals,
raising
potential
for
new
animal
reservoirs.
study
utilized
systematic
approach
gather,
analyse,
interpret
data
regarding
global
outbreaks,
phylogenomics,
human
APOBEC3
enzyme
activity,
antiviral
resistance
issues,
application
One
Health
intervention.
Emphasizing
covers
various
aspects,
zoonotic
origins,
pathogenesis,
changing
epidemiological
landscapes,
phylogenomic
diversity,
clade
dynamics.
review
underscores
crucial
role
collaboration
in
understanding
combatting
making
it
valuable
resource
shaping
effective
prevention
control
measures
on
scale.
Frontiers in Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Июль 20, 2023
Human
monkeypox
is
a
zoonotic
infection
that
similar
to
the
diseases
caused
by
other
poxviruses.
It
endemic
among
wild
rodents
in
rainforests
of
Central
and
Western
Africa,
can
be
transmitted
via
direct
skin
contact
or
mucosal
exposure
infected
animals.
The
initial
symptoms
include
fever,
headache,
myalgia,
fatigue,
lymphadenopathy,
last
which
main
symptom
distinguishes
it
from
smallpox.
In
order
prevent
manage
disease,
those
who
are
must
rapidly
diagnosed
isolated.
Several
vaccines
have
already
been
developed
(e.g.,
JYNNEOS,
ACAM2000
ACAM3000)
antiviral
drugs
cidofovir
tecovirimat)
also
used
treat
disease.
present
study,
we
reviewed
history,
morphology,
clinical
presentations,
transmission
routes,
diagnosis,
prevention,
potential
treatment
strategies
for
monkeypox,
enable
health
authorities
physicians
better
deal
with
this
emerging
crisis.
Vaccine,
Год журнала:
2024,
Номер
42(7), С. 1841 - 1849
Опубликована: Фев. 3, 2024
The
Mpox
(formerly
named
Monkeypox)
virus
is
the
etiological
cause
of
a
recent
multi-country
outbreak,
with
thousands
distinct
cases
detected
outside
endemic
areas
Africa
as
December
2023.
In
this
article,
we
analyze
sequences
full
genomes
from
Europe
and
compare
them
all
available
historical
relevance,
annotated
by
year
geographic
origin,
well
related
Cowpox
Variola
(smallpox)
sequences.
Our
results
show
that
outbreak
most
likely
originating
West
African
clade
Mpox,
>99
%
sequence
identity
derived
cases,
dating
1971
to
2017.
We
specific
mutations
occurring
in
viral
proteins
between
current
previous
sequences,
virus.
Genome-wide
analysis
other
Mpox/Cowpox/Variola
viruses
shows
very
high
conservation,
97.9
(protein-based)
97.8
(nucleotide-based)
identity.
identified
significant
correlation
human
transcriptional
responses
well,
conserved
immune
pathway
response
induced
cell
cultures
three
families
Pox
similarities
major
strains
viruses,
within
clades,
both
at
genomic
transcriptomic
levels,
provide
molecular
basis
for
observed
efficacy
vaccines
Poxviruses.
Reviews in Medical Virology,
Год журнала:
2024,
Номер
34(3)
Опубликована: Май 1, 2024
Abstract
As
the
mankind
counters
ongoing
COVID‐19
pandemic
by
novel
severe
acute
respiratory
syndrome
coronavirus‐2
(SARS‐CoV‐2),
it
simultaneously
witnesses
emergence
of
mpox
virus
(MPXV)
that
signals
at
global
spread
and
could
potentially
lead
to
another
pandemic.
Although
MPXV
has
existed
for
more
than
50
years
now
with
most
human
cases
being
reported
from
endemic
West
Central
African
regions,
disease
is
recently
in
non‐endemic
regions
too
affect
countries.
Controlling
important
due
its
potential
danger
a
spread,
causing
morbidity
mortality.
The
article
highlights
transmission
dynamics,
zoonosis
potential,
complication
mitigation
strategies
infection,
concludes
suggested
‘one
health’
approach
better
management,
control
prevention.
Bibliometric
analyses
data
extend
understanding
provide
leads
on
research
trends,
need
revamp
critical
healthcare
interventions.
Globally
published
mpox‐related
literature
does
not
align
well
areas/regions
occurrence
which
should
ideally
have
been
scenario.
Such
demographic
geographic
gaps
between
location
work
epicentres
be
bridged
greater
effective
translation
outputs
pubic
systems,
suggested.
