An evaluation of the preprints produced at the beginning of the 2022 mpox public health emergency DOI Creative Commons

Melanie Sterian,

Anmol Samra,

Kusala Pussegoda

и другие.

Research Integrity and Peer Review, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 6, 2024

Abstract Background Preprints are scientific articles that have not undergone the peer-review process. They allow latest evidence to be rapidly shared, however it is unclear whether they can confidently used for decision-making during a public health emergency. This study aimed compare data and quality of preprints released first four months 2022 mpox outbreak their published versions. Methods Eligible ( n = 76) posted between May August were identified through an established literature database followed July 2024 changes in publication status. Quality studies was assessed by two independent reviewers evaluate quality, using validated tools available design 33). Tools included Newcastle-Ottawa Scale; Assessment Diagnostic Accuracy Studies 2 (QUADAS-2); JBI Critical Appraisal Checklists. The questions each tool led overall assessment high (no concerns with design, conduct, and/or analysis), moderate (minor concerns) or low (several concerns). Changes (e.g. methods, outcomes, results) preprint-published pairs 60) one reviewer verified second. Results versions could evaluated 25 pairs) mostly as quality. Minimal no change from preprint identified: all observational (10/10), most case series (6/7) surveillance analyses (3/3) had while some diagnostic test accuracy (3/5) improved worsened scores. Among 60), outcomes often added version (58%) less commonly removed (18%). Numerical results changed 53% studies, these (22/32) minor did impact main conclusions study. Conclusions suggests minimal supports use preprints, same critical evaluation on applied

Язык: Английский

Phylogenomic analysis of the monkeypox virus (MPXV) 2022 outbreak: Emergence of a novel viral lineage? DOI
Nicolás Luna, Angie Ramírez, Marina Muñoz

и другие.

Travel Medicine and Infectious Disease, Год журнала: 2022, Номер 49, С. 102402 - 102402

Опубликована: Июль 13, 2022

Язык: Английский

Процитировано

167
Complete Genome Sequencing, Annotation, and Mutational Profiling of the Novel Clade I Human Mpox Virus, Kamituga Strain DOI Creative Commons

Leandre Murhula Masirika,

Anuj Kumar,

Mansi Dutt

и другие.

The Journal of Infection in Developing Countries, Год журнала: 2024, Номер 18(04), С. 600 - 608

Опубликована: Апрель 30, 2024

Introduction: Human Mpox (formerly monkeypox) infection is an emerging zoonotic disease caused by the virus (MPXV). We describe complete genome annotation, phylogeny, and mutational profile of a novel, sustained Clade I outbreak in city Kamituga Eastern Democratic Republic Congo (DRC). Methodology: A cross-sectional, observational, cohort study was performed among patients all ages admitted to Hospital with symptoms between late September 2023 January 2024. DNA isolated from swabbed lesions sequenced followed phylogenetic analysis, profiling. Results: ongoing Kamituga, South Kivu Province, Congo. Whole-genome sequencing viral RNA samples revealed, on average, 201.5 snps, 28 insertions, 81 deletions, 2 indels, 312.5 total variants, 158.3 amino acid changes, 81.66 intergenic 72.16 synonymous mutations, 106 missense 41.16 frameshift 3.33 inframe deletions across six samples. By assigning mutations at proteome level for MPXV sequences, we observed that seven proteins, namely, C9L (OPG047), I4L (OPG080), L6R (OPG105), A17L (OPG143), A25R (OPG151), A28L (OPG153), B21R (OPG210) have emerged as hot spot based consensuses acids substitutions. Based outcome found deletion D14L (OPG032) gene Following analysis whole assembly, determined this cluster infections genetically distinct previously reported outbreaks, thus propose represents novel subgroup (subgroup VI) MPXV. Conclusions: Here report first time. This presents oubtreaks, suggesting (we term VI). These findings underscore need vigilance continued threats endemic regions.

Язык: Английский

Процитировано

21
The recent re-emergence of human monkeypox: Would it become endemic beyond Africa? DOI Creative Commons
Mohamad S. Hakim, Suci Ardini Widyaningsih

Journal of Infection and Public Health, Год журнала: 2023, Номер 16(3), С. 332 - 340

Опубликована: Янв. 18, 2023

Viral outbreaks still become global health challenges, for instance, influenza A viruses, Japanese encephalitis, Ebola virus, Yellow fever, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since 7 May 2022, another outbreak of monkeypox also has been reported in European countries the United States. Meanwhile, virus is previously endemic only western central parts Africa. Monkeypox a zoonotic disease, although primary animal reservoir remains unknown. This article concisely reviews its transmission, pathogenesis, clinical manifestation, changing epidemiology before during current outbreak, possible driving factors recent outbreak. Furthermore, we discuss whether would beyond Even though available data suggests that human-to-human transmission currently happening unconnected clusters exist, many efforts have made to tackle this such as active case detection, contact tracing, isolation, postexposure vaccination.

Язык: Английский

Процитировано

35
From Entry to Evasion: A Comprehensive Analysis of Host-Virus Interactions for Monkeypox DOI Creative Commons

Vahideh Hamidi Sofiani,

Mohammad Rezaei Zadeh Rukerd, Javad Charostad

и другие.

Infectious Microbes & Diseases, Год журнала: 2024, Номер 6(2), С. 56 - 64

Опубликована: Май 21, 2024

Abstract Monkeypox (Mpox) has posed a novel challenge and emerged as threat to global public health since the onset of its outbreak in 2022. Mpox is spreading throughout world both endemic non-endemic countries, indicating that behavior evolving. The prevalence risk pandemic necessitate better understanding virus replications interactions with host. Here, we attempted provide detailed comprehensive review at molecular level from entry establishment successful infection, including attachment entry, DNA replication, protein expression viron assembly egress. This also describes strategies evade host immune responses inhibit apoptosis, uncovers underlying mechanisms such subverted signaling pathways cellular factors behind host-viral interactions.

Язык: Английский

Процитировано

7
Monkeypox in Germany DOI
Christian Hoffmann,

Heiko Jessen,

Christoph Boesecke

и другие.

Deutsches Ärzteblatt international, Год журнала: 2022, Номер unknown

Опубликована: Июль 27, 2022

Many cases of monkeypox have been reported across Europe from early May 2022 onward. Initial publications suggest that nearly all the affected persons to date men who sex with (MSM).

Язык: Английский

Процитировано

26
Strengthening Africa’s response to Mpox (monkeypox): insights from historical outbreaks and the present global spread DOI Creative Commons
David B. Olawade, Ojima Z. Wada,

Sandra Chinaza Fidelis

и другие.

Science in One Health, Год журнала: 2024, Номер 3, С. 100085 - 100085

Опубликована: Янв. 1, 2024

Mpox, formerly known as Monkeypox, is a viral zoonotic disease endemic to Central and West Africa that has posed significant public health challenges since its identification in 1970. Despite decades of experience managing outbreaks, the 2022-2024 Mpox outbreaks exposed substantial gaps global preparedness response, leading World Health Organization (WHO) declare Public Emergency International Concern (PHEIC) 2022. The resurgence cases Europe 2022 more recent emergence virulent clade Ⅰb Democratic Republic Congo (DRC) 2024 have highlighted critical need for improved proactive response strategies curb epidemic. This narrative review examines historical epidemiology explores factors limited effective management. These include objective influences such mutations, transmission patterns, environmental changes like deforestation, well subjective factors, including delayed responses, vaccine availability, cessation smallpox vaccinations, inequitable access healthcare. In particular, emphasizes ongoing disparities equity, wealthier nations been able secure vaccines therapeutics quickly, while regions continue struggle with resources. also discusses how socio-economic cultural combined weak infrastructure inadequate surveillance systems, perpetuate cycles outbreak vulnerable populations. Furthermore, 2024, higher virulence mortality rates among children, particularly rural areas, underscores urgency addressing evolving epidemiological landscape Mpox. these challenges, this recommends strengthening healthcare infrastructure, enhancing ensuring equitable treatments, integrating management into strategies. Global collaboration remains essential provide African countries resources support needed manage prevent future effectively. Without measures, world risks prolonged crisis far-reaching consequences both community.

Язык: Английский

Процитировано

6
Genetic stability of Mpox virus during in-vitro serial passaging: Insights from mutational analysis DOI Creative Commons

Jasmine Khurana,

Yagnya Joshi,

Sanjay Yadav

и другие.

Infection Genetics and Evolution, Год журнала: 2025, Номер unknown, С. 105748 - 105748

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Genomic Evolution and Epidemiological Impact of Ongoing Clade Ib MPox Disease: A Narrative Review DOI Creative Commons
Adewunmi Akingbola, Adegbesan Abiodun Christopher, Courage Idahor

и другие.

Global Health, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Clade 1b of the MPox virus has emerged as a highly virulent strain, causing significant public health challenges globally. Initially endemic to Central Africa, this strain spread nonendemic regions, including Europe, Asia, and Americas. With its high transmission rate severe outcomes, especially among vulnerable populations like children, raised global concerns. The Africa Center for Disease Control Prevention (CDC) declared it emergency international concern. shows higher case fatality increased transmissibility compared other strains. It moved beyond traditional zoonotic widespread human-to-human transmission. variant's countries such Sweden Thailand demonstrates reach. Public efforts, cross-border coordination, rapid response teams, awareness campaigns, have been essential in containing outbreaks. However, barriers limited resources, vaccine shortages, logistical conflict-affected areas hindered effective control, particularly low-resource regions. severity highlight need cooperation strengthen surveillance, improve diagnostic capabilities, expand healthcare infrastructure affected areas. Enhancing access vaccines treatments, along with educating on preventive measures, will be key controlling Ongoing research monitoring are mitigate future outbreaks minimize virus's impact.

Язык: Английский

Процитировано

0
Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans DOI Creative Commons
Barbara S. Schnierle

Viruses, Год журнала: 2022, Номер 14(9), С. 1874 - 1874

Опубликована: Авг. 25, 2022

In the late 1970s, global vaccination programs resulted in eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to smallpox-inducing variola virus, was previously endemic only Sub-Saharan Africa but currently spreading worldwide. Only older people who have been vaccinated against smallpox are expected be sufficiently protected poxviruses. Here I will summarize current knowledge about disease caused by MPXV infections, and strategies limit its spread.

Язык: Английский

Процитировано

16
Exploring the genomic basis of Mpox virus-host transmission and pathogenesis DOI Creative Commons

Brayden Young,

Stephanie N. Seifert,

Crystal Lawson

и другие.

mSphere, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Mpox disease, caused by the monkeypox virus (MPXV), was recently classified as a public health emergency of international concern due to its high lethality and pandemic potential. MPXV is zoonotic disease that emerged primarily spread small rodents. Historically, it considered mainly not likely sustain human-to-human transmission. However, worldwide outbreak Clade IIb from 2020 2022 ongoing I epidemics in Democratic Republic Congo surrounding areas are warning human-adapted MPXVs will continually arise. Understanding viral genetic determinants host range, pathogenesis, immune evasion imperative for developing control strategies predicting future Mpox. Here, we delve into genome detail genes involved this rodent-borne human-circulating virus. We compare gene content related Orthopoxviruses, which have narrow ranges, identify potential species-specific pathogenesis tropism. In addition, cover key virulence factor differences distinguish clade lineages. Finally, dissect how genomic reduction through various molecular mechanisms, contributing generation novel lineages with increased human adaptation. This review aims highlight defines species, clades, culminated being elevated national concern.

Язык: Английский

Процитировано

1