Dyslipidemia
is
a
common
comorbidity
in
patients
with
cancer,
yet
the
impact
of
abnormal
lipid
levels
on
tumor
prognosis
remains
contentious.
This
study
was
conducted
to
synthesize
current
evidence
regarding
prognostic
utility
blood
levels,
including
high-density
lipoprotein
cholesterol
(HDL-C),
low-density
(LDL-C),
total
(TC),
triglycerides
(TG),
apolipoprotein
A1
(ApoA1),
and
B
(ApoB),
predicting
overall
survival
(OS)
disease-free
(DFS)
cancer
patients.
A
comprehensive
literature
search
performed
across
electronic
databases
assess
associations
between
OS
or
DFS
Pooled
hazard
ratios
(HRs)
95%
confidence
intervals
(CIs)
were
calculated
analyze
data.
The
research
protocol
previously
submitted
International
Prospective
Register
Systematic
Reviews
(PROSPERO):
CRD42023458597.
Our
represents
largest
most
extensive
evaluation
significance
date.
It
includes
meta-analysis
156
eligible
studies
involving
85,173
findings
revealed
significant
association
elevated
HDL-C,
TC,
ApoA1
improved
In
contrast,
no
relationships
identified
LDL-C,
TG,
ApoB
Blood
lipids,
particularly
ApoA1,
emerge
as
accessible
cost-effective
biomarkers
that
may
aid
assessing
outcomes
potentially
inform
clinical
decision-making.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 31, 2023
Inflammatory
bowel
disease
(IBD),
a
general
term
encompassing
Crohn’s
(CD)
and
ulcerative
colitis
(UC),
other
conditions,
is
chronic
relapsing
autoimmune
that
can
occur
in
any
part
of
the
digestive
tract.
While
cause
IBD
remains
unclear,
it
acknowledged
has
much
to
do
with
dysregulation
intestinal
immunity.
In
immune
regulatory
system,
Cholesterol-25-hydroxylase
(CH25H)
plays
an
important
role
regulating
function
cells
lipid
metabolism
through
catalyzing
oxidation
cholesterol
into
25-hydroxycholesterol
(25-HC).
Specifically,
CH25H
focuses
its
mechanism
inflammatory
response,
signal
transduction
cell
migration
on
various
types
by
binding
relevant
receptors,
via
transcription
factor
Sterol
Regulator-Binding
Protein.
Based
this
foundation,
article
will
review
immunity,
aiming
provide
evidence
for
supporting
discovery
early
diagnostic
treatment
targets
IBD.
The Journal of Steroid Biochemistry and Molecular Biology,
Год журнала:
2024,
Номер
241, С. 106519 - 106519
Опубликована: Апрель 12, 2024
Phytosterols
are
lipophilic
compounds
found
in
plants
with
structural
similarity
to
mammalian
cholesterol.
They
cannot
be
endogenously
produced
by
mammals
and
therefore
always
originate
from
diet.
There
has
been
increased
interest
dietary
phytosterols
over
the
last
few
decades
due
their
association
a
variety
of
beneficial
health
effects
including
low-density
lipoprotein
cholesterol
lowering,
anti-inflammatory
anti-cancerous
effects.
proposed
as
potential
moderators
for
diseases
associated
central
nervous
system
where
homeostasis
is
imperative
(multiple
sclerosis,
dementia,
etc.)
ability
reach
brain.
Here
we
utilised
an
enzyme-assisted
derivatisation
sterol
analysis
(EADSA)
combination
liquid
chromatography
tandem
mass
spectrometry
(LC-MSn)
characterise
phytosterol
content
human
serum.
As
little
100
fg
plant
was
injected
on
reversed
phase
LC
column.
The
method
allows
semi-quantitative
measurements
derivatives
simultaneously
measurement
metabolites.
identification
serum
based
comparison
retention
times
MS2,
MS3
spectra
library
authentic
standards.
Free
campesterol
concentration
range
0.30
-
4.10
µg/mL,
β-sitosterol
0.16
3.37
µg/mL
fucosterol
at
lowest
0.05
0.38
ten
individuals.
This
analytical
methodology
could
applied
other
biological
fluids
tissues.
Dyslipidemia
is
a
common
comorbidity
in
patients
with
cancer,
yet
the
impact
of
abnormal
lipid
levels
on
tumor
prognosis
remains
contentious.
This
study
was
conducted
to
synthesize
current
evidence
regarding
prognostic
utility
blood
levels,
including
high-density
lipoprotein
cholesterol
(HDL-C),
low-density
(LDL-C),
total
(TC),
triglycerides
(TG),
apolipoprotein
A1
(ApoA1),
and
B
(ApoB),
predicting
overall
survival
(OS)
disease-free
(DFS)
cancer
patients.
A
comprehensive
literature
search
performed
across
electronic
databases
assess
associations
between
OS
or
DFS
Pooled
hazard
ratios
(HRs)
95%
confidence
intervals
(CIs)
were
calculated
analyze
data.
The
research
protocol
previously
submitted
International
Prospective
Register
Systematic
Reviews
(PROSPERO):
CRD42023458597.
Our
represents
largest
most
extensive
evaluation
significance
date.
It
includes
meta-analysis
156
eligible
studies
involving
85,173
findings
revealed
significant
association
elevated
HDL-C,
TC,
ApoA1
improved
In
contrast,
no
relationships
identified
LDL-C,
TG,
ApoB
Blood
lipids,
particularly
ApoA1,
emerge
as
accessible
cost-effective
biomarkers
that
may
aid
assessing
outcomes
potentially
inform
clinical
decision-making.
