Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 31, 2023

Inflammatory bowel disease (IBD), a general term encompassing Crohn’s (CD) and ulcerative colitis (UC), other conditions, is chronic relapsing autoimmune that can occur in any part of the digestive tract. While cause IBD remains unclear, it acknowledged has much to do with dysregulation intestinal immunity. In immune regulatory system, Cholesterol-25-hydroxylase (CH25H) plays an important role regulating function cells lipid metabolism through catalyzing oxidation cholesterol into 25-hydroxycholesterol (25-HC). Specifically, CH25H focuses its mechanism inflammatory response, signal transduction cell migration on various types by binding relevant receptors, via transcription factor Sterol Regulator-Binding Protein. Based this foundation, article will review immunity, aiming provide evidence for supporting discovery early diagnostic treatment targets IBD.

Language: Английский

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Impaired hepatic lipid metabolism and biomarkers in fatty liver disease

Biochimie, Journal Year: 2023, Volume and Issue: 215, P. 69 - 74

Published: Sept. 26, 2023

Language: Английский

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Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 211, P. 89 - 95

Published: Dec. 13, 2023

Language: Английский

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Phytosterols in human serum as measured using a liquid chromatography tandem mass spectrometry

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 241, P. 106519 - 106519

Published: April 12, 2024

Phytosterols are lipophilic compounds found in plants with structural similarity to mammalian cholesterol. They cannot be endogenously produced by mammals and therefore always originate from diet. There has been increased interest dietary phytosterols over the last few decades due their association a variety of beneficial health effects including low-density lipoprotein cholesterol lowering, anti-inflammatory anti-cancerous effects. proposed as potential moderators for diseases associated central nervous system where homeostasis is imperative (multiple sclerosis, dementia, etc.) ability reach brain. Here we utilised an enzyme-assisted derivatisation sterol analysis (EADSA) combination liquid chromatography tandem mass spectrometry (LC-MSn) characterise phytosterol content human serum. As little 100 fg plant was injected on reversed phase LC column. The method allows semi-quantitative measurements derivatives simultaneously measurement metabolites. identification serum based comparison retention times MS2, MS3 spectra library authentic standards. Free campesterol concentration range 0.30 - 4.10 µg/mL, β-sitosterol 0.16 3.37 µg/mL fucosterol at lowest 0.05 0.38 ten individuals. This analytical methodology could applied other biological fluids tissues.

Language: Английский

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Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers

Advances in experimental medicine and biology, Journal Year: 2023, Volume and Issue: unknown, P. 379 - 400

Published: Dec. 1, 2023

Language: Английский

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