Respiratory Medicine, Год журнала: 2024, Номер unknown, С. 107918 - 107918
Опубликована: Дек. 1, 2024
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Март 5, 2024
Osteoporosis is a common chronic metabolic bone disorder. Recently, increasing numbers of studies have demonstrated that Toll-like receptor 4 (TLR4, located on the surface osteoclasts and osteoblasts) plays pivotal role in development osteoporosis. Herein, we performed comprehensive review to summarize findings from relevant within this topic. Clinical data showed TLR4 polymorphisms aberrant expression been associated with clinical significance Mechanistically, dysregulation osteoblasts induced by abnormal main molecular mechanism underlying pathological processes osteoporosis, which may be interactions between NF-κB pathway, proinflammatory effects, ncRNAs, RUNX2.
Язык: Английский
Процитировано
9
Free Radical Biology and Medicine, Год журнала: 2024, Номер 212, С. 403 - 414
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
8
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Rational regulation of reactive oxygen species (ROS) plays a vital importance in maintaining homeostasis living biological systems. For ROS-related pathologies, chemotherapy technology derived from metal nanomaterials currently occupies pivotal position. However, they suffer inherent issues such as complicated synthesis, batch-to-batch variability, high cost, and potential toxicity caused by elements. Here, we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalene-structured small-molecule enzyme imitator (DHKNase) exhibited 2-edged ROS regulation, catering to execution physiology-beneficial destiny among diverse pathologies Based on this, DHKNase is validated enable remarkable therapeutic effects 2 classic disease models, including pathogen-infected wound-healing model dextran sulfate sodium (DSS)-caused inflammatory bowel (IBD). This work provides guiding landmark developing novel natural significantly expands their application biomedical field.
Язык: Английский
Процитировано
4
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 8, 2024
Osteoporosis is a common chronic metabolic bone disease caused by disturbances in normal metabolism and an imbalance between osteoblasts osteoclasts. characterized decrease mass density, leading to increased fragility. usually treated with medications surgical methods, but these methods often produce certain side effects. Therefore, the use of traditional herbal ingredients for treatment osteoporosis has become focus attention hot topic recent years. Curcumin, widely distributed among herbs such as turmeric, tulip, curcuma longa, contains phenolic, terpenoid, flavonoid components. Modern pharmacological studies have confirmed that curcumin variety functions including antioxidant anti-inflammatory properties. In addition, positively regulates differentiation promotes proliferation osteoblasts, which play crucial role formation. Multiple shown effective it interacts signaling pathway targets, thereby interfering formation osteoclasts regulating development osteoporosis. This review summarized key pathways their mechanisms action prevention analyzed characteristics relationship curcumin. not only proves medicinal value ingredient also further elucidates molecular mechanism curcumin's anti-osteoporosis effect, providing new perspectives through multiple pathways.
Язык: Английский
Процитировано
4
Molecules, Год журнала: 2025, Номер 30(7), С. 1504 - 1504
Опубликована: Март 28, 2025
Enriched or fortified foods are typically linked to ultra-processed foods, limiting the choice of functional food in market. Addressing market potential, particularly elder population with osteoporosis, industry should consider developing a healthy snack enriched bioactive substances. This study aimed produce freeze-dried Polish Gala apple improved antioxidant properties and calcium content via impregnation osmotic dehydration process. The solutions containing various concentrations sea buckthorn (SB) juice inulin were prepared at different temperatures times, then analyzed by response surface regression modelling. Subsequently, effect addition 0–6% lactate (CaL) on was also studied. Freeze-dried apple, after 93.8% SB juice, 0:100 inulin–SB ratio, 30 °C for 120 min, 4% CaL (hereafter called “4% CaL” treatment), possessed minimum yet acceptable loss increased (2209.13 mg Ca/100 g). UPLC-PDA revealed altered compositions phenolics (flavonols dominated isorhamnetin-3-O-glucoside isorhamnetin-3-O-rutinoside) carotenoids CaL. exhibited lower polyphenol oxidase peroxidase activities, moderate sensory acceptability soft texture, better nutritional values calories when compared controls. work is scalable study, covering aspects process design, physicochemical, nutritional, enzymatic properties, as well profiling, which has potential industrial implementation.
Язык: Английский
Процитировано
0
Journal of Advanced Research, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Severe acute pancreatitis (SAP) is a critical inflammatory disease with high morbidity and mortality. Current treatments focused on symptomatic relief but failed to prevent inflammation progression in cellular level. In order develop an SAP-targeting drug delivery system alleviate SAP level illustrate its mechanism, we explored the use of proanthocyanidin (PYD) pentoxifylline (PTX) loaded into macrophage membrane-coated self-assembly nanoparticles (FePTX@CM NPs) for targeted treatment. The combination application these two drugs was innovative aid. We developed NPs by strategy cell membrane coating. Its particle size zeta potential were measured dynamic light scatter (DLS). morphology observed transmission electron microscopy (TEM). And encapsulation efficiency evaluated nano-flow cytometry. total protein profile determined via Coomassie brilliant blue. explore mechanism our against animal levels. Bioinformatics approaches, TEM, immunofluorescent assay co-immunoprecipitation performed comprehensively explain specific anti-SAP FePTX@CM NPs. After inflammation-driven targeting, PYD inhibited pancreatic amylase lipase release suppressing mitochondrial reactive oxygen species (mtROS)/Golgi stress, while PTX prevented SAP-associated PANoptosis inhibiting Zbp1 signal pathway. protection effect biomimetic worked from different aspects symptoms relative cells. demonstrated effective pancreas reduced systemic especially pro-inflammatory recruitment activation, minimized tissue damage mouse models, offering promising therapeutic clinical management.
Язык: Английский
Процитировано
0
Food Research International, Год журнала: 2025, Номер 212, С. 116462 - 116462
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
0
Bone, Год журнала: 2025, Номер unknown, С. 117496 - 117496
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Physiology, Год журнала: 2025, Номер 16
Опубликована: Май 27, 2025
Tumor necrosis factor receptor-associated factors (TRAFs) are crucial intracellular signaling proteins in bone homeostasis. TRAFs mediate pathways associated with remodeling, particularly response to inflammatory stimuli, influencing osteoclast differentiation and function. Dysregulation of TRAF-mediated contributes significantly osteoporosis, a condition marked by increased resorption fragility. Natural products, their anti-inflammatory antioxidant properties, offer promising therapeutic potential targeting TRAF-associated inhibit excessive activity promote formation. This review explores the mechanisms which natural compounds modulate TRAF osteoclastogenesis osteoblastogenesis, providing insights into for osteoporosis treatment.
Язык: Английский
Процитировано
0
Functional Food Science - Online ISSN 2767-3146, Год журнала: 2024, Номер 4(3), С. 96 - 118
Опубликована: Март 25, 2024
Mammalian gastrointestinal tract is inhabited by trillions of symbiotic microbiotas representing viruses, bacteria, archaea and eukaryotes including yeasts, fungi protozoa. Compared to humans, the herbivores harbor a complex metabolically efficient microbes which not only detoxify inadvertently consumed anti-nutritional phytochemicals, but also convert ingested tannin-polyphenols, saponins, phytoestrogens alkaloids into metabolites are more available bioactive than their precursors. Some toxicants eliminate them from body. The resulting display range nutritional therapeutic benefits besides direct impact on enhancing diversity functioning gut microbiome. Metabolically active microbiota generated might be futuristic alternative biotherapeutics develop nutraceuticals plant-based health formulations primarily for ‘metabotype 0’ individuals. Further insights novel microbial species, modes biotransformation phytochemicals botanicals will pave way non-antibiotic interventions avert infections boost human veterinary health. Keywords: Gut microbiome; Phytochemicals; Biotransformation; Biotherapeutics Highlights: dietary prevent host against chronic diseases infections. Little known about metabolism action GI herbal supplements. having anti-inflammatory, anti-oxidative anti-carcinogenic properties therapeutics.
Язык: Английский
Процитировано
2