Food Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 142580 - 142580
Published: Dec. 1, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 5, 2024
Osteoporosis is a common chronic metabolic bone disorder. Recently, increasing numbers of studies have demonstrated that Toll-like receptor 4 (TLR4, located on the surface osteoclasts and osteoblasts) plays pivotal role in development osteoporosis. Herein, we performed comprehensive review to summarize findings from relevant within this topic. Clinical data showed TLR4 polymorphisms aberrant expression been associated with clinical significance Mechanistically, dysregulation osteoblasts induced by abnormal main molecular mechanism underlying pathological processes osteoporosis, which may be interactions between NF-κB pathway, proinflammatory effects, ncRNAs, RUNX2.
Language: Английский
Citations
8
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 212, P. 403 - 414
Published: Jan. 1, 2024
Language: Английский
Citations
8
Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1504 - 1504
Published: March 28, 2025
Enriched or fortified foods are typically linked to ultra-processed foods, limiting the choice of functional food in market. Addressing market potential, particularly elder population with osteoporosis, industry should consider developing a healthy snack enriched bioactive substances. This study aimed produce freeze-dried Polish Gala apple improved antioxidant properties and calcium content via impregnation osmotic dehydration process. The solutions containing various concentrations sea buckthorn (SB) juice inulin were prepared at different temperatures times, then analyzed by response surface regression modelling. Subsequently, effect addition 0–6% lactate (CaL) on was also studied. Freeze-dried apple, after 93.8% SB juice, 0:100 inulin–SB ratio, 30 °C for 120 min, 4% CaL (hereafter called “4% CaL” treatment), possessed minimum yet acceptable loss increased (2209.13 mg Ca/100 g). UPLC-PDA revealed altered compositions phenolics (flavonols dominated isorhamnetin-3-O-glucoside isorhamnetin-3-O-rutinoside) carotenoids CaL. exhibited lower polyphenol oxidase peroxidase activities, moderate sensory acceptability soft texture, better nutritional values calories when compared controls. work is scalable study, covering aspects process design, physicochemical, nutritional, enzymatic properties, as well profiling, which has potential industrial implementation.
Language: Английский
Citations
0
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Severe acute pancreatitis (SAP) is a critical inflammatory disease with high morbidity and mortality. Current treatments focused on symptomatic relief but failed to prevent inflammation progression in cellular level. In order develop an SAP-targeting drug delivery system alleviate SAP level illustrate its mechanism, we explored the use of proanthocyanidin (PYD) pentoxifylline (PTX) loaded into macrophage membrane-coated self-assembly nanoparticles (FePTX@CM NPs) for targeted treatment. The combination application these two drugs was innovative aid. We developed NPs by strategy cell membrane coating. Its particle size zeta potential were measured dynamic light scatter (DLS). morphology observed transmission electron microscopy (TEM). And encapsulation efficiency evaluated nano-flow cytometry. total protein profile determined via Coomassie brilliant blue. explore mechanism our against animal levels. Bioinformatics approaches, TEM, immunofluorescent assay co-immunoprecipitation performed comprehensively explain specific anti-SAP FePTX@CM NPs. After inflammation-driven targeting, PYD inhibited pancreatic amylase lipase release suppressing mitochondrial reactive oxygen species (mtROS)/Golgi stress, while PTX prevented SAP-associated PANoptosis inhibiting Zbp1 signal pathway. protection effect biomimetic worked from different aspects symptoms relative cells. demonstrated effective pancreas reduced systemic especially pro-inflammatory recruitment activation, minimized tissue damage mouse models, offering promising therapeutic clinical management.
Language: Английский
Citations
0
Bone, Journal Year: 2025, Volume and Issue: unknown, P. 117496 - 117496
Published: April 1, 2025
Language: Английский
Citations
0
Food Research International, Journal Year: 2025, Volume and Issue: 212, P. 116462 - 116462
Published: April 23, 2025
Language: Английский
Citations
0
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Rational regulation of reactive oxygen species (ROS) plays a vital importance in maintaining homeostasis living biological systems. For ROS-related pathologies, chemotherapy technology derived from metal nanomaterials currently occupies pivotal position. However, they suffer inherent issues such as complicated synthesis, batch-to-batch variability, high cost, and potential toxicity caused by elements. Here, we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalene-structured small-molecule enzyme imitator (DHKNase) exhibited 2-edged ROS regulation, catering to execution physiology-beneficial destiny among diverse pathologies Based on this, DHKNase is validated enable remarkable therapeutic effects 2 classic disease models, including pathogen-infected wound-healing model dextran sulfate sodium (DSS)-caused inflammatory bowel (IBD). This work provides guiding landmark developing novel natural significantly expands their application biomedical field.
Language: Английский
Citations
2
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 29, 2024
In recent years, there has been a growing interest in the potential health benefits of phytoestrogens, diverse group naturally occurring compounds found plants. These compounds, with structural similarities to estrogen, are foods such as soybeans, flaxseeds and sesame seeds, studied for their roles modulating hormonal activity antioxidant properties. Their estrogen-like functions make them particularly interesting managing conditions exacerbated by imbalances, type 2 diabetes, obesity, cardiovascular diseases, osteoporosis. Phytoestrogens enhance insulin sensitivity glucose metabolism, while anti-oxidant properties neutralize free radicals inhibit lipid peroxidation. They also influence fat metabolism reduce adipogenesis, addressing oxidative stress inflammation. estrogenic effects improve bone mineral density fracture risks, postmenopausal women, highlighting broad metabolic disease management. This body research suggests that due unique mechanisms action, could be valuable addition dietary therapeutic strategies prevention management various diseases. chapter delves into multifaceted phytoestrogens disorders, special focus on
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 8, 2024
Osteoporosis is a common chronic metabolic bone disease caused by disturbances in normal metabolism and an imbalance between osteoblasts osteoclasts. characterized decrease mass density, leading to increased fragility. usually treated with medications surgical methods, but these methods often produce certain side effects. Therefore, the use of traditional herbal ingredients for treatment osteoporosis has become focus attention hot topic recent years. Curcumin, widely distributed among herbs such as turmeric, tulip, curcuma longa, contains phenolic, terpenoid, flavonoid components. Modern pharmacological studies have confirmed that curcumin variety functions including antioxidant anti-inflammatory properties. In addition, positively regulates differentiation promotes proliferation osteoblasts, which play crucial role formation. Multiple shown effective it interacts signaling pathway targets, thereby interfering formation osteoclasts regulating development osteoporosis. This review summarized key pathways their mechanisms action prevention analyzed characteristics relationship curcumin. not only proves medicinal value ingredient also further elucidates molecular mechanism curcumin's anti-osteoporosis effect, providing new perspectives through multiple pathways.
Language: Английский
Citations
1
Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 19, 2024
Language: Английский
Citations
1