Опубликована: Янв. 1, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Янв. 24, 2025
Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.
Язык: Английский
Процитировано
5
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102664 - 102664
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Brain Sciences, Год журнала: 2024, Номер 14(5), С. 471 - 471
Опубликована: Май 7, 2024
Plastic production, which exceeds one million tons per year, is of global concern. The constituent low-density polymers enable spread over large distances and micro/nano particles (MNPLs) induce organ toxicity via digestion, inhalation, skin contact. Particles have been documented in all human tissues including breast milk. MNPLs, especially weathered particles, can breach the blood–brain barrier, inducing neurotoxicity. This has non-human species, human-induced pluripotent stem cell lines. Within brain, MNPLs initiate an inflammatory response with pro-inflammatory cytokine oxidative stress generation reactive oxygen mitochondrial dysfunction. Glutamate GABA neurotransmitter dysfunction also ensues alteration excitatory/inhibitory balance favor reduced inhibition resultant neuro-excitation. Inflammation cortical hyperexcitability are key abnormalities involved pathogenic cascade amyotrophic lateral sclerosis (ALS) intricately related to mislocalization aggregation TDP-43, a hallmark ALS. Water many foods contain humans, ingestion main form exposure. Digestion plastics within gut alter their properties, rendering them more toxic, they cause microbiome dysbiosis dysfunctional gut–brain axis. recognized as trigger and/or aggravating factor for ALS associated long (years or decades) preclinical period neonates infants exposed through milk, milk substitutes, toys. endangers time intense neurogenesis establishment neuronal circuitry, setting stage development neurodegeneration later life. MNPL neurotoxicity should be considered yet unrecognized risk diseases.
Язык: Английский
Процитировано
6
Food Chemistry, Год журнала: 2025, Номер 478, С. 143674 - 143674
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 123 - 175
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
Purpose of review (Poly)phenols are bioactive compounds in plant-based foods with well documented health benefits. Their metabolism dependent on gut microbiota composition, diversity, and function, which modulate their bioavailability physiological effects. This examines recent insights into (poly)phenol-gut interactions, emphasizing relevance mediating benefits mechanisms action. Recent findings studies have identified a high interindividual variability (poly)phenol metabolism, explored microbial-derived metabolites potential benefits, revealed bidirectional influences between (poly)phenols composition. Advances analytical techniques large-scale refined our understanding these but inconsistencies remain linking specific microbial signatures to outcomes. Summary Standardized methodologies long-term needed clarify the impact (poly)phenol-derived human health. Future research should focus personalized targeted nutrition approaches optimize
Язык: Английский
Процитировано
0
International review of neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117101 - 117101
Опубликована: Июль 14, 2024
Puerarin, a monomer of traditional Chinese medicine, is key component Pueraria radix. Both clinical and experimental researches demonstrated that puerarin has therapeutic effects on Parkinson's disease (PD). Puerarin's pharmacological mechanisms include: 1) Anti-apoptosis. Puerarin inhibits cell apoptosis through the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) c-Jun N-terminal (JNK) signaling pathways. also exerts hormone-like effect against apoptosis; 2) Anti-oxidative stress injury. Nrf2 nuclear exclusion GSK-3β/Fyn pathway to promote accumulation in nucleus, then promotes antioxidant synthesis Nrf2/ARE protect oxidative stress; 3) Neuroprotective by intervening ubiquitin-proteasome system (UPS) autophagy-lysosomal (ALP). significantly enhances activity chaperone-mediated autophagy (CMA), which downregulates expression α-synuclein, reduces its accumulation, thus improves function damaged neurons. Additionally, increases proteasome decreases ubiquitin-binding proteins, thereby preventing toxic intracellular proteins; 4) Alleviating inflammatory response. conversion microglia M1 phenotype while inducing transition M2 phenotype. Furthermore, secretion anti-inflammatory factor pro-inflammatory factors; 5) Increasing levels dopamine metabolites. could increase dopamine, homovanillic acid (HVA) 3,4-dihydroxyphenylacetic (DOPAC) striatum; 6) Promoting neurotrophic neuronal repair. glial cell-derived (GDNF), brain-derived (BDNF) nerve growth (NGF), exerting neuroprotective effect. Moreover, regulation gut microbiota may be potential mechanism for treatment PD. The current review discusses molecular puerarin, provide insight into active components medicine
Язык: Английский
Процитировано
3
Molecules, Год журнала: 2024, Номер 29(24), С. 6026 - 6026
Опубликована: Дек. 20, 2024
High consumption of ultra-processed foods, rich in sugar and unhealthy fats, has been linked to the onset numerous chronic diseases. Consequently, there a growing shift towards fiber-rich diet, abundant fruits, vegetables, seeds, nuts, enhance longevity quality life. The primary bioactive components these plant-based foods are polyphenols, which exert significant effects on modulating gastrointestinal microbiota through their antioxidant anti-inflammatory activities. This modulation preventive neurodegenerative, metabolic, cardiovascular diseases, even cancer. antimicrobial properties polyphenols against pathogenic bacteria have significantly reduced need for antibiotics, thereby lowering risk antibiotic resistance. paper advances field by offering novel insights into beneficial both directly metabolites produced during digestion indirectly changes host’s microbiota, uniquely emphasizing swine as model highly relevant human health, topic that, our knowledge, not thoroughly explored previous reviews. review also addresses aspects related other animal models (mice, rabbits, rats), humans, providing guidelines future research benefits polyphenol consumption. By linking agricultural biomedical perspectives, it proposes strategies utilizing compounds therapeutic agents veterinary health sciences.
Язык: Английский
Процитировано
2
Food Bioscience, Год журнала: 2024, Номер 60, С. 104091 - 104091
Опубликована: Май 23, 2024
Язык: Английский
Процитировано
1