Journal of Pharmaceutical Analysis,
Год журнала:
2023,
Номер
14(12), С. 100925 - 100925
Опубликована: Дек. 21, 2023
Cartilage
is
solid
connective
tissue
that
recovers
slowly
from
injury,
and
pain
dysfunction
cartilage
damage
affect
many
people.
The
treatment
of
injury
clinically
challenging
there
no
optimal
solution,
which
a
hot
research
topic
at
present.
With
the
rapid
development
3D
printing
technology
in
recent
years,
bioprinting
can
better
mimic
complex
microstructure
thus
enabling
anatomy
functional
regeneration
damaged
cartilage.
This
article
reviews
methods
used
to
structures,
selection
cells
biological
factors,
bioinks
advances
scaffold
with
an
emphasis
on
how
structure
provides
bioactive
cargos
each
stage
enhance
effect.
Finally,
clinical
applications
future
simulated
are
introduced,
expected
provide
new
insights
into
this
field
guide
other
researchers
who
engaged
repair.
Journal of Orthopaedic Translation,
Год журнала:
2024,
Номер
45, С. 24 - 35
Опубликована: Март 1, 2024
Fracture-related
infection
(FRI)
remains
a
major
concern
in
orthopaedic
trauma.
Functionalizing
implants
with
antibacterial
coatings
are
promising
strategy
mitigating
FRI.
Numerous
implant
have
been
reported
but
the
preventive
and
therapeutic
effects
vary.
This
systematic
review
aimed
to
provide
comprehensive
overview
of
current
coating
strategies
prevent
treat
FRI
animal
fracture
bone
defect
models.
A
literature
search
was
performed
three
databases:
PubMed,
Web
Science
Embase,
predetermined
keywords
criteria
up
28
February
2023.
Preclinical
studies
on
or
models
that
assessed
healing
were
included.
total
14
included
this
review,
seven
which
used
Passive
bacteria
adhesion
resistance
investigated
two
studies.
Active
bactericidal
12
studies,
four
metal
ions
including
Ag+
Cu2+;
five
antibiotics
chlorhexidine,
tigecycline,
vancomycin,
gentamicin
sulfate;
other
natural
materials
chitosan,
antimicrobial
peptides,
lysostaphin.
Overall,
these
exhibited
efficacy
formation.
Antibacterial
reduced
bacterial
infections
favored
vivo.
Future
should
focus
optimal
biocompatibility,
against
multi-drug
resistant
polymicrobial
infections,
osseointegration
osteogenesis
promotion
especially
osteoporotic
by
constructing
multi-functional
for
therapy.
The
clinical
treatment
is
complex
challenging.
summarizes
novel
applied
preclinical
offers
perspective
future
development
coatings,
can
potentially
contribute
alternative
practice.
European Polymer Journal,
Год журнала:
2024,
Номер
215, С. 113243 - 113243
Опубликована: Июль 1, 2024
Osteoarthritis
(OA)
is
a
well-known
degenerative
joint
disease
recognized
by
the
deterioration
of
cartilage
in
joints,
leading
to
pain
and
reduced
mobility.
Traditional
treatments
for
OA
include
management,
physical
therapy,
severe
cases,
replacement
surgery.
In
recent
years,
there
has
been
growing
interest
exploring
potential
phytoconstituents
nanomedicines
combined
treating
OA.
Furthermore,
with
increasing
amount
study
this
field,
now
opportune
time
widespread
use
plant-derived
medications
as
complementary
alternative
medical
therapies
be
acknowledged
used
more
efficient
treatment
human
ailments
like
Combining
nanomedicine
technology
(phyto-nanomedicine)
can
potentially
enhance
their
effectiveness
The
phyto-nanomedicines
many
advantages,
including
enhanced
permeability,
increased
bioavailability,
sustained/controlled
drug
release
at
site,
decreased
adverse
effects,
possible
combination
treatment.
It's
important
note
that
while
promising
preclinical
some
clinical
evidence
regarding
phyto-nanomedicine
treatment,
further
research
needed
establish
safety
efficacy
conclusively.
review,
treat
combining
phytomedicines
nanoparticulate
delivery
former
therapeutic
discussed
detail.
we
have
also
described
briefly
on
application
organ-on-chip
and/or
on-chip
models
accelerate
identification
novel
evaluate
potency
Virtual and Physical Prototyping,
Год журнала:
2024,
Номер
19(1)
Опубликована: Авг. 30, 2024
Advanced
three-dimensional
(3D)
bioprinting
technology
enables
the
precise
production
of
complex
vascular
structures
and
biomimetic
models,
driving
advancements
in
tissue
engineering
disease
mechanism
research.
At
core
this
is
smart
bioink,
which
suitable
for
fabricating
models
that
can
be
vascularised
to
meet
property
requirements
various
tissues.
Examples
bioinks
include
decellularized
extracellular
matrix
(dECM),
photocrosslinkable,
reversible,
microgel-based
biphasic
(MB)
bioinks,
whose
mechanical
properties
tuned
through
external
stimuli.
This
tuning
helps
generate
high-resolution
complex-shaped
networks
essential
cell
survival
functional
maturation.
review
explores
advanced
3D
strategies
using
spatially
controlled
perfusable
vitro
emphasising
reconstruction
within
bioprinted
models.
It
also
discusses
challenges
future
prospects,
suggesting
could
serve
as
alternatives
traditional
animal
modelling
drug
screening.
Biomimetics,
Год журнала:
2025,
Номер
10(2), С. 95 - 95
Опубликована: Фев. 8, 2025
Tissue
engineering
is
an
emerging
field
within
biomedicine,
related
to
developing
functional
substitutes
for
damaged
tissues
or
organs.
Despite
significant
advancements,
the
development
of
effective
tissue
constructs
remains
challenging,
particularly
when
replicating
elastic
stretchability,
which
plays
a
critical
role
in
many
tissues.
Therefore,
tough,
elastomeric
scaffolds
that
mimic
complex
elasticity
native
tissues,
such
as
myocardium,
heart
valves,
and
blood
vessels,
particular
interest.
This
study
aims
evaluate
flexible
printable
material
(Formlabs'
Elastic
50A
Resin
V2)
develop
porous
3D
using
additive
manufacturing
stereolithography
(SLA).
The
samples
were
tested
relation
their
swelling
behaviour,
mechanical
properties,
exposure
low
temperatures.
Additionally,
effects
print
orientation,
water
immersion,
temperatures
on
surface
roughness
porosity
investigated
determine
best
conditions
enhance
scaffold
performance
biomedical
applications.
results
demonstrated
printed
at
0°,
immersed
water,
exposed
temperature
(-80
°C)
showed
more
uniform
microporosity,
could
improve
adhesion
growth
cells
scaffold.
research
highlights
practical
economical
approach
enhancing
scaffolds,
paving
way
improved
outcomes
Regenerative Medicine,
Год журнала:
2025,
Номер
20(1), С. 45 - 55
Опубликована: Янв. 2, 2025
Articular
cartilage
lesion
frequently
leads
to
dysfunction
and
the
development
of
degenerative
diseases,
posing
a
significant
public
health
challenge
due
limited
self-healing
capacity
tissue.
Current
surgical
treatments,
including
marrow
stimulation
techniques
osteochondral
autografts/allografts,
have
efficacy
or
drawbacks,
highlighting
urgent
need
for
alternative
strategies.
Advances
in
3D
printing
regeneration
shown
promising
potential
creating
cartilage-mimicking
constructs,
thereby
opening
new
possibilities
repair.
In
this
review,
we
summarize
current
treatment
methods
their
limitations
addressing
articular
lesion,
various
strategies
features
tissue
engineering,
seed
cells
from
different
sources,
types
biomaterials.
We
also
explore
benefits,
challenges,
future
research
directions
within
field
engineering.
