Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(12)
Опубликована: Янв. 15, 2024
Abstract Point‐of‐care (POC) has the capacity to support low‐cost, accurate and real‐time actionable diagnostic data. Microneedle sensors have received considerable attention as an emerging technique evolve blood‐based diagnostics owing their direct painless access a rich source of biomarkers from interstitial fluid. This review systematically summarizes recent innovations in microneedle with particular focus on utility POC personalized medicine. The integration various sensing techniques, mostly electrochemical optical sensing, been established diverse architectures “lab‐on‐a‐microneedle” platforms. tailored geometries, mechanical flexibility, biocompatibility are constructed variety materials fabrication methods. Microneedles categorized into four types: metals, inorganics, polymers, hydrogels, elaborated state‐of‐the‐art bioengineering strategies for minimally invasive, continuous, multiplexed sensing. employed detect wide range electrolytes, metabolites, polysaccharides, nucleic acids, proteins drugs. Insightful perspectives outlined biofluid, microneedles, biosensors, devices, theragnostic instruments, which depict bright future upcoming intelligent health management.
Язык: Английский
Процитировано
39
Analytical Chemistry, Год журнала: 2024, Номер 96(20), С. 8160 - 8183
Опубликована: Фев. 20, 2024
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTChallenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring Biofluids: From Lab to Market. A ReviewHossein ChenaniHossein ChenaniDepartment Materials Science Engineering, Sharif University Technology, 14588 89694 Tehran, IranMore by Hossein ChenaniView Biographyhttps://orcid.org/0009-0009-6924-6491, Mohsen Saeidi*Mohsen SaeidiDepartment Iran*Tel: +98-21-6616 5262; Fax: +98-21-6600 5717; Email: [email protected]More SaeidiView Biographyhttps://orcid.org/0000-0001-5430-3339, MahsaSadat Adel RastkhizMahsaSadat RastkhizDepartment RastkhizView Biographyhttps://orcid.org/0009-0002-6628-6868, Nafiseh BolghanabadiNafiseh BolghanabadiDepartment BolghanabadiView Biographyhttps://orcid.org/0009-0004-1151-2201, Amir AghaiiAmir AghaiiDepartment AghaiiView Biographyhttps://orcid.org/0009-0006-2561-9119, Mina OroujiMina OroujiDepartment OroujiView Biographyhttps://orcid.org/0009-0007-6375-6437, HatamieAmir HatamieDepartment Chemistry Molecular Biology, Gothenburg, Sweden; Department Chemistry, Institute Advanced Studies in Basic Sciences (IASBS), Prof. Sobouti Boulevard, PO Box 45195-1159, Zanjan 45137-66731, HatamieView Biographyhttps://orcid.org/0000-0002-7085-893X, Abdolreza Simchi*Abdolreza SimchiDepartment IranCenter Bioscience Convergence Tehran 14588-89694, 5226; SimchiView Biographyhttps://orcid.org/0000-0002-9111-2977Cite this: Anal. Chem. 2024, 96, 20, 8160–8183Publication Date (Web):February 2024Publication History Received2 September 2023Accepted1 February 2024Revised24 January 2024Published online20 inissue 21 May 2024https://pubs.acs.org/doi/10.1021/acs.analchem.3c03942https://doi.org/10.1021/acs.analchem.3c03942review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views1518Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biotechnology,Carbohydrates,Electrodes,Hydrogels,Sensors Get e-Alerts
Язык: Английский
Процитировано
36
Microsystems & Nanoengineering, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
7
TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер 187, С. 118208 - 118208
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
3
ACS Sensors, Год журнала: 2023, Номер 8(11), С. 4161 - 4170
Опубликована: Окт. 19, 2023
Wearable devices based on microneedle (MN) technology have recently emerged as tools for in situ transdermal sensing or delivery interstitial fluid (ISF). Particularly, MN-based electrochemical sensors allow the continuous monitoring of analytes a minimally invasive manner through ISF. Exogenous small molecules found ISF such therapeutic drugs are ideal candidates MN due to their correlation with blood levels and relevance optimal management personalized therapies. Herein, hollow array patch is modified conductive pastes functionalized cross-linked chitosan develop an voltammetric sensor methotrexate (MTX). Interestingly, coating avoids biofouling while enabling adsorption MTX at electrode's surface sensitive analysis. The exhibits excellent analytical performance vitro protein-enriched artificial ex vivo under Franz diffusion cell configuration. shows linear range from 25 400 μM, which fits within high-dose treatment cancer patients operation more than two days. Moreover, iontophoretic developed integration both anode cathode single patch. characterization demonstrates on-demand drug MTX. Overall, combination patches represents impactful progress closed-loop systems disorders cancer, rheumatoid arthritis, psoriasis.
Язык: Английский
Процитировано
41
International Journal of Pharmaceutics, Год журнала: 2023, Номер 637, С. 122888 - 122888
Опубликована: Март 26, 2023
Microneedle-based technologies are the subject of intense research and commercial interest for applications in transdermal delivery diagnostics, primarily because their minimally invasive painless nature, which turn could lead to increased patient compliance self-administration. In this paper, a process fabrication arrays hollow silicon microneedles is described. This method uses just two bulk etches - front-side wet etch define 500 μm tall octagonal needle structure itself, rear-side dry create 50 diameter bore through needle. reduces number complexity over approaches described elsewhere. Ex-vivo human skin customised applicator were used demonstrate biomechanical reliability feasibility using these both diagnostics. Microneedle show no damage even when applied up 40 times, capable delivering several mL fluid at flowrates 30 μL/min, withdrawing 1 μL interstitial capillary action.
Язык: Английский
Процитировано
32
Small, Год журнала: 2024, Номер 20(26)
Опубликована: Фев. 22, 2024
Abstract Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture stratum corneum layer of skin lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, drug administration. offer limited invasiveness, ease application, minimal discomfort. Initially manufactured solely from metals, now available polymer‐based varieties. can be used create systems that deliver drugs chemicals uniformly, collect fluids, stimulus‐sensitive. Although these advancements favorable terms biocompatibility production costs, they insufficient for use MNs. This is first comprehensive review discusses individual MN toward evolution development smart multifunctional a variety novel impactful future applications. The study examines fabrication techniques, application purposes, experimental details constructs perform multiple concurrently, sensing, drug‐molecule release, sampling, remote communication capabilities. It highly likely near future, MN‐based will useful important component standard practice different
Язык: Английский
Процитировано
16
Biosensors and Bioelectronics, Год журнала: 2024, Номер 250, С. 116066 - 116066
Опубликована: Янв. 23, 2024
Язык: Английский
Процитировано
15
Gels, Год журнала: 2024, Номер 10(1), С. 65 - 65
Опубликована: Янв. 15, 2024
Microneedles are of great interest in diverse fields, including cosmetics, drug delivery systems, chromatography, and biological sensing for disease diagnosis. Self-dissolving ultrafine microneedles pure sodium hyaluronate hydrogels were fabricated using a UV-curing TiO
Язык: Английский
Процитировано
7
ACS Sensors, Год журнала: 2024, Номер 9(5), С. 2294 - 2309
Опубликована: Апрель 24, 2024
Bioanalyte collection by blood draw is a painful process, prone to needle phobia and injuries. Microneedles can be engineered penetrate the epidermal skin barrier collect analytes from interstitial fluid, arising as safe, painless, effective alternative hypodermic needles. Although there are plenty of reviews on various types microneedles their use drug delivery systems, lack systematization application polymeric for diagnosis. In this review, we focus current state art field, while providing information safety, preclinical clinical trials, market distribution, outline what believe will future health monitoring.
Язык: Английский
Процитировано
7