Frontiers in Analytical Science,
Год журнала:
2025,
Номер
4
Опубликована: Янв. 7, 2025
Next-generation
non-invasive
biochemical
wearables
hold
promise
in
transforming
healthcare
by
providing
real-time,
continuous
monitoring
of
markers.
Non-invasive
methods
include
smart
tattoos,
microneedle
patches,
wearable
biosensors,
flexible
bioelectronics,
implantable
sensors,
textiles,
and
contact
lenses.
A
comprehensive
picture
an
individual’s
health
can
be
detected
via
critical
markers
such
as
glucose,
lactate,
cortisol,
volatile
organic
compounds
(VOCs)
from
sweat,
saliva,
tears,
breath
interstitial
fluid
(ISF)-based,
minimally
invasive
biosensors
using
these
advanced
technologies.
Personalized
insights
for
enhancing
their
functionality
are
possible
integrating
them
with
AI
big
data
analytics
early
disease
detection
proactive
management.
This
study
explores
the
potential
futuristic
wearables,
current
status,
underlying
technologies,
associated
applications
challenges,
positioning
transformative
solutions
personalized
redefining
future
monitoring.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(35), С. 8577 - 8604
Опубликована: Янв. 1, 2024
Biosensors
integrated
into
closed-loop
systems
provide
patient-specific
adaptive
therapies.
These
advanced
devices
have
significant
potential
for
managing
chronic
conditions
by
continuously
adjusting
therapeutic
regimens
based
on
physiological
data.
This
comprehensive
review
underscores
the
pivotal
role
wearable
electrochemical
sensors
play
in
proactive
management
and
prevention
of
diabetes
mellitus
(DM)
its
associated
complications.
Acknowledging
substantial
impact
DM
on
individuals
urgency
for
effective
monitoring
strategies,
have
emerged
as
a
pragmatic
solution.
These
can
detect
analytical
signals
from
biofluids,
including
sweat,
tears,
saliva,
interstitial
fluid
(ISF),
employing
minimally
invasive
techniques
facilitated
by
technological
advancements.
The
seamless
integration
these
with
computational
platforms
such
smartphones
enhances
their
practicality
routine
use.
systematically
explores
diverse
methodologies,
encompassing
both
enzymatic
non-enzymatic
principles,
employed
surveillance
analytes
within
biofluids.
foundational
principles
are
meticulously
applied
to
devices,
affording
point-of-care
solutions
catering
detection
individual
or
simultaneous
multiplexed
analyte
detection.
wireless
systems
incorporation
machine
learning
algorithms
introduce
layer
sophistication,
elevating
capability
nuanced
Through
an
in-depth
analysis
advancements,
this
describes
significant
potential
essential
tool
real-time
managing
DM.
approaches
presented
underscore
adaptability,
versatility,
inherent
efficacy
addressing
multifaceted
challenges
intrinsic
complications
academic
discourse.
The
lack
of
infrastructure
and
accessibility
in
medical
treatments
has
been
considered
as
a
global
chronic
issue
since
the
concept
treatment
prevention
was
presented.
After
COVID-19
pandemic,
reaction
capability
for
epidemic
outbreak/spread
spotlighted
critical
to
fore
worldwide.
To
reduce
burden
on
system
from
simultaneous
disease
emergence,
personalized
wearable
electronic
systems
have
arisen
next-generation
biomedical
monitoring/treating
equipment
infectious
diseases
at
initial
stage.
In
particular,
skin
(e-skin)
with
its
potential
multifunctional
extendibility
enabled
be
applied
long-term
healthcare
devices
real-time
biosignal
sensing.
Here,
we
introduce
recent
enhancements
various
e-skin
applications
terms
material
types
device
structures,
including
sensor
components,
biological
signal
sensing
mechanisms,
applicable
technological
advancements,
utilization.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101504 - 101504
Опубликована: Янв. 19, 2025
Integrating
advanced
manufacturing
techniques
and
nanotechnology
with
cutting-edge
materials
has
driven
significant
progress
in
global
healthcare.
Microneedles,
recognized
for
their
minimally
invasive
approach
to
transdermal
sensing
drug
delivery,
achieve
enhanced
functionality
when
combined
iontophoresis.
Iontophoresis-assisted
microneedles
have
emerged
as
an
innovative
solution,
enabling
real-time
biosensing
precise
delivery
within
closed-loop
systems.
These
integrated
platforms
represent
a
major
advancement
personalized
medicine,
allowing
dynamic
therapeutic
adjustments
based
on
continuous
feedback.
This
review
highlights
the
latest
developments
iontophoresis-assisted
biosensing,
applications.
It
delves
into
mechanisms
of
iontophoresis,
assesses
its
advantages
limitations,
explores
future
directions
these
transformative
technologies.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 18, 2025
The
need
for
precise
modulation
of
blood
concentrations
pharmaceutical
molecule,
especially
high-risk
drugs
like
Methotrexate
(MTX),
is
underscored
by
the
significant
impact
individual
variations
on
treatment
efficacy.
Achieving
selective
recognition
molecules
within
complex
biological
environment
a
substantial
challenge.
To
tackle
this,
we
propose
synergistic
atomic-molecular
docking
strategy
that
utilizes
hybrid-dual
single-atom
Fe1-Zn1
TiO2
photoelectrode
to
selectively
bind
carboxyl
and
aminopyrimidine
groups
MTX
respectively.
By
integrating
this
Fe1-Zn1-TiO2
with
microcomputer
system,
an
implantable
photoelectrochemical-therapeutic
drug
monitoring
(PEC-TDM)
system
developed
real-time,
continuous
in
vivo
monitoring.
This
facilitates
personalized
therapeutic
decision-making
intelligent
delivery
individualized
cancer
therapy,
potentially
revolutionizing
oncological
care
enhancing
patient
outcomes.
Concentration
methotrexate
(MTX)
needs
monitoring,
Here,
authors
MTX.
