Future directions: what LIES ahead for smart biochemical wearables in health monitoring? DOI Creative Commons

Simmi Kharb

Frontiers in Analytical Science, Год журнала: 2025, Номер 4

Опубликована: Янв. 7, 2025

Next-generation non-invasive biochemical wearables hold promise in transforming healthcare by providing real-time, continuous monitoring of markers. Non-invasive methods include smart tattoos, microneedle patches, wearable biosensors, flexible bioelectronics, implantable sensors, textiles, and contact lenses. A comprehensive picture an individual’s health can be detected via critical markers such as glucose, lactate, cortisol, volatile organic compounds (VOCs) from sweat, saliva, tears, breath interstitial fluid (ISF)-based, minimally invasive biosensors using these advanced technologies. Personalized insights for enhancing their functionality are possible integrating them with AI big data analytics early disease detection proactive management. This study explores the potential futuristic wearables, current status, underlying technologies, associated applications challenges, positioning transformative solutions personalized redefining future monitoring.

Язык: Английский

A 3D-printed hollow microneedle-based electrochemical sensing device for in situ plant health monitoring DOI
Marc Parrilla, Amadeo Sena‐Torralba, Annemarijn Steijlen

и другие.

Biosensors and Bioelectronics, Год журнала: 2024, Номер 251, С. 116131 - 116131

Опубликована: Фев. 13, 2024

Язык: Английский

Процитировано

28

Tailoring Design of Microneedles for Drug Delivery and Biosensing DOI

Yuexi Lin,

Muamer Dervisevic, Hao Zhe Yoh

и другие.

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.

Язык: Английский

Процитировано

3

Wearable and implantable biosensors: mechanisms and applications in closed-loop therapeutic systems DOI Creative Commons
Zeyuan Zheng,

Runjin Zhu,

Ian Peng

и другие.

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(35), С. 8577 - 8604

Опубликована: Янв. 1, 2024

Biosensors integrated into closed-loop systems provide patient-specific adaptive therapies. These advanced devices have significant potential for managing chronic conditions by continuously adjusting therapeutic regimens based on physiological data.

Язык: Английский

Процитировано

16

Wearable electrochemical sensors for real-time monitoring in diabetes mellitus and associated complications DOI Open Access
Han Hee Jung,

Hyeokjun Lee,

Junwoo Yea

и другие.

Soft Science, Год журнала: 2024, Номер 4(2)

Опубликована: Апрель 22, 2024

This comprehensive review underscores the pivotal role wearable electrochemical sensors play in proactive management and prevention of diabetes mellitus (DM) its associated complications. Acknowledging substantial impact DM on individuals urgency for effective monitoring strategies, have emerged as a pragmatic solution. These can detect analytical signals from biofluids, including sweat, tears, saliva, interstitial fluid (ISF), employing minimally invasive techniques facilitated by technological advancements. The seamless integration these with computational platforms such smartphones enhances their practicality routine use. systematically explores diverse methodologies, encompassing both enzymatic non-enzymatic principles, employed surveillance analytes within biofluids. foundational principles are meticulously applied to devices, affording point-of-care solutions catering detection individual or simultaneous multiplexed analyte detection. wireless systems incorporation machine learning algorithms introduce layer sophistication, elevating capability nuanced Through an in-depth analysis advancements, this describes significant potential essential tool real-time managing DM. approaches presented underscore adaptability, versatility, inherent efficacy addressing multifaceted challenges intrinsic complications academic discourse.

Язык: Английский

Процитировано

14

Body-attachable multifunctional electronic skins for bio-signal monitoring and therapeutic applications DOI Open Access

Kang Hyeon Kim,

Jeong Hyeon Kim,

Yu Jin Ko

и другие.

Soft Science, Год журнала: 2024, Номер 4(3)

Опубликована: Июнь 12, 2024

The lack of infrastructure and accessibility in medical treatments has been considered as a global chronic issue since the concept treatment prevention was presented. After COVID-19 pandemic, reaction capability for epidemic outbreak/spread spotlighted critical to fore worldwide. To reduce burden on system from simultaneous disease emergence, personalized wearable electronic systems have arisen next-generation biomedical monitoring/treating equipment infectious diseases at initial stage. In particular, skin (e-skin) with its potential multifunctional extendibility enabled be applied long-term healthcare devices real-time biosignal sensing. Here, we introduce recent enhancements various e-skin applications terms material types device structures, including sensor components, biological signal sensing mechanisms, applicable technological advancements, utilization.

Язык: Английский

Процитировано

12

Trends in ready-to-use portable electrochemical sensing devices for healthcare diagnosis DOI

Anjana Sajeevan,

Reshmi A. Sukumaran,

Lakshmi R. Panicker

и другие.

Microchimica Acta, Год журнала: 2025, Номер 192(2)

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

2

Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery DOI Creative Commons
Gaobo Wang,

Noboru MORIYAMA,

Soichiro Tottori

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101504 - 101504

Опубликована: Янв. 19, 2025

Integrating advanced manufacturing techniques and nanotechnology with cutting-edge materials has driven significant progress in global healthcare. Microneedles, recognized for their minimally invasive approach to transdermal sensing drug delivery, achieve enhanced functionality when combined iontophoresis. Iontophoresis-assisted microneedles have emerged as an innovative solution, enabling real-time biosensing precise delivery within closed-loop systems. These integrated platforms represent a major advancement personalized medicine, allowing dynamic therapeutic adjustments based on continuous feedback. This review highlights the latest developments iontophoresis-assisted biosensing, applications. It delves into mechanisms of iontophoresis, assesses its advantages limitations, explores future directions these transformative technologies.

Язык: Английский

Процитировано

2

Implantable photoelectrochemical-therapeutic methotrexate monitoring system with dual-atomic docking strategy DOI Creative Commons
Xiankui Xu, Dawei Xu, Xue Zhou

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 18, 2025

The need for precise modulation of blood concentrations pharmaceutical molecule, especially high-risk drugs like Methotrexate (MTX), is underscored by the significant impact individual variations on treatment efficacy. Achieving selective recognition molecules within complex biological environment a substantial challenge. To tackle this, we propose synergistic atomic-molecular docking strategy that utilizes hybrid-dual single-atom Fe1-Zn1 TiO2 photoelectrode to selectively bind carboxyl and aminopyrimidine groups MTX respectively. By integrating this Fe1-Zn1-TiO2 with microcomputer system, an implantable photoelectrochemical-therapeutic drug monitoring (PEC-TDM) system developed real-time, continuous in vivo monitoring. This facilitates personalized therapeutic decision-making intelligent delivery individualized cancer therapy, potentially revolutionizing oncological care enhancing patient outcomes. Concentration methotrexate (MTX) needs monitoring, Here, authors MTX.

Язык: Английский

Процитировано

2

Harnessing the role of microneedles as sensors: current status and future perspectives DOI
Molakpogu Ravindra Babu, Sukriti Vishwas,

Monica Gulati

и другие.

Drug Discovery Today, Год журнала: 2024, Номер 29(7), С. 104030 - 104030

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

9

Microneedles-Based Theranostic Platform: From the Past to the Future DOI
Ziyang Li, Yuhan Wang,

R Q Zhang

и другие.

ACS Nano, Год журнала: 2024, Номер 18(35), С. 23876 - 23893

Опубликована: Авг. 23, 2024

Fully integrated theranostic devices are highly esteemed in clinical applications, offering immense potential real-time disease monitoring and personalized care. Microneedles (MNs), as innovative wearable devices, boast important advantages biosensing therapy, thus holding significant promise the advancement of diagnostic therapeutic platforms. Encouragingly, advancements electrochemical sensing technology, micronano fabrication, biocompatible materials propelling momentum for MNs-based closed-loop systems, enhancing detection capabilities, biocompatibility, cost-effectiveness. Moreover, notable progress integrating MN chips with other biochips signifies a frontier growth. Successful trials target molecule drug delivery domains herald excellent translational prospects aforementioned platform. Finally, we delineate both challenges opportunities development including continuous monitoring, intelligent control algorithms, safety, regulatory considerations.

Язык: Английский

Процитировано

9