Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention

Life, Год журнала: 2025, Номер 15(1), С. 49 - 49

Опубликована: Янв. 2, 2025

Biofilms, composed of structured communities bacteria embedded in a self-produced extracellular matrix, pose significant challenge due to their heightened resistance antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic within bacterial biofilms, elucidating adaptive strategies employed by microorganisms withstand conventional antimicrobial agents. encompasses role altered gene expression, formation persister cells, contributing recalcitrance biofilms eradication. A comprehensive understanding these provides for exploring innovative therapeutic interventions. study explores promising avenues future research, emphasizing necessity uncovering specific genetic phenotypic adaptations occurring biofilms. The identification vulnerabilities biofilm architecture elucidation key biofilm-specific targets emerge as crucial focal points development targeted strategies. In addressing limitations traditional antibiotics, this discusses approaches. Nanomaterials with inherent properties, quorum-sensing inhibitors disrupting communication, bacteriophages viral agents are highlighted potential alternatives. exploration combination therapies, involving agents, biofilm-disrupting enzymes, immunomodulators, is emphasized enhance efficacy existing treatments overcome resilience.

Язык: Английский

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Copper-zinc metal complex exhibiting bactericidal and antibiofilm activity by membrane damage and quorum sensing inhibition

Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(3), С. 112889 - 112889

Опубликована: Апрель 24, 2024

Язык: Английский

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Biofilm Formation And Antibiotic Resistance in Pseudomonas aeruginosa

The Microbe, Год журнала: 2024, Номер 3, С. 100078 - 100078

Опубликована: Май 10, 2024

The accelerating rise of multi-drug resistance and resultant difficulties in the treatment Pseudomonas aeruginosa infections are a significant cause high morbidity mortality infected patients. Antimicrobial resulting from biofilm contributes to disease burden on public health P.aeruginosa serves as model for investigating development. Biofilm makes slime layer over various surfaces (epithelial layer, contact lenses, human teeth, urinary catheters, rocks) when bacteria break away complex aggregation; source serious healthcare-associated that mainly systemic. is characteristic about 99% bacterial species resistive protective barrier varied antibiotics. communities form pillar-like structures. About 10% strains resistant antibiotics account 8% tract pneumonia disorders. Resistance achieved by numerous phenomena such reducing outer membrane permeability, using an efflux pump, specialized enzymatical activity, formation, horizontal resistive-gene transfer, mutations, etc. In this study, we evaluated every aspect 1) related its factors impacting role antibiotic especially Pseudomonas. 2) Mechanisms through which P.aeroginosa illustrates intrinsic, adaptive well acquired toward 3) Furthermore, modern treat these also overviewed. Recently, novel therapeutic approaches have played may include non-antibiotic or be used with more effective.

Язык: Английский

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Detection and Treatment with Peptide Power: A New Weapon Against Bacterial Biofilms

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Bacterial biofilms, complex microbial communities encased in a protective extracellular matrix, pose significant threat to public health due their inherent antibiotic resistance. This review explores the potential of peptides, particularly antimicrobial peptides (AMPs), as innovative tools combat biofilm-related infections. AMPs, characterized by potent activity and tissue permeability, offer promising approach overcome challenges posed biofilms. By disrupting biofilm architecture, inhibiting bacterial growth, enhancing detection through nuclear-based, fluorescence-based, nanobased techniques, AMPs provide multifaceted strategy. highlights recent advancements, approaches, strategies peptide research, examining both diagnostic therapeutic agents. It also addresses key outlines future directions for optimizing peptide-based therapies. overcoming these refining design, we can unlock full combating infections, paving way development solutions tackle diseases improve global health.

Язык: Английский

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Synthesis and Characterization of Zinc Oxide Nanoparticles Functionalized with Ellagic Acid: Antibacterial and Antibiofilm Properties and Effect on the Expression of Biofilm Related Genes in Pseudomonas aeruginosa

Journal of Cluster Science, Год журнала: 2025, Номер 36(2)

Опубликована: Фев. 2, 2025

Язык: Английский

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SERS-assisted characterization of cell biomass from biofilm-forming Acinetobacter baumannii strains using chemometric tools

RSC Advances, Год журнала: 2025, Номер 15(6), С. 4581 - 4592

Опубликована: Янв. 1, 2025

Acinetobacter baumannii ( A. ) is an emerging Gram-negative nosocomial pathogen responsible for infection on a global scale.

Язык: Английский

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Understanding the mechanism of nitrogen removal from the perspective of extracellular polymeric substances characteristics and nitrogen metabolic pathways under varying aeration rates in an aerobic fluidized bed biofilm reactor

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 116018 - 116018

Опубликована: Фев. 1, 2025

Язык: Английский

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Biofilm-Mediated Infections; Novel Therapeutic Approaches and Harnessing Artificial Intelligence for Early Detection and Treatment of Biofilm-Associated Infections

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107497 - 107497

Опубликована: Март 1, 2025

Язык: Английский

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Multifunctional Bioactivity of the [Cu(en)(Im)2](ClO4)2 Complex: Antimicrobial, Antibiofilm, and Anticancer Effects

The Microbe, Год журнала: 2025, Номер unknown, С. 100307 - 100307

Опубликована: Март 1, 2025

Язык: Английский

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Antimicrobial applications of inorganic radiosensitizers and their potential in biofilm control

World Journal of Microbiology and Biotechnology, Год журнала: 2025, Номер 41(4)

Опубликована: Апрель 1, 2025

Язык: Английский

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