The Microbe,
Journal Year:
2024,
Volume and Issue:
3, P. 100078 - 100078
Published: May 10, 2024
The
accelerating
rise
of
multi-drug
resistance
and
resultant
difficulties
in
the
treatment
Pseudomonas
aeruginosa
infections
are
a
significant
cause
high
morbidity
mortality
infected
patients.
Antimicrobial
resulting
from
biofilm
contributes
to
disease
burden
on
public
health
P.aeruginosa
serves
as
model
for
investigating
development.
Biofilm
makes
slime
layer
over
various
surfaces
(epithelial
layer,
contact
lenses,
human
teeth,
urinary
catheters,
rocks)
when
bacteria
break
away
complex
aggregation;
source
serious
healthcare-associated
that
mainly
systemic.
is
characteristic
about
99%
bacterial
species
resistive
protective
barrier
varied
antibiotics.
communities
form
pillar-like
structures.
About
10%
strains
resistant
antibiotics
account
8%
tract
pneumonia
disorders.
Resistance
achieved
by
numerous
phenomena
such
reducing
outer
membrane
permeability,
using
an
efflux
pump,
specialized
enzymatical
activity,
formation,
horizontal
resistive-gene
transfer,
mutations,
etc.
In
this
study,
we
evaluated
every
aspect
1)
related
its
factors
impacting
role
antibiotic
especially
Pseudomonas.
2)
Mechanisms
through
which
P.aeroginosa
illustrates
intrinsic,
adaptive
well
acquired
toward
3)
Furthermore,
modern
treat
these
also
overviewed.
Recently,
novel
therapeutic
approaches
have
played
may
include
non-antibiotic
or
be
used
with
more
effective.
Bacterial
biofilms,
complex
microbial
communities
encased
in
a
protective
extracellular
matrix,
pose
significant
threat
to
public
health
due
their
inherent
antibiotic
resistance.
This
review
explores
the
potential
of
peptides,
particularly
antimicrobial
peptides
(AMPs),
as
innovative
tools
combat
biofilm-related
infections.
AMPs,
characterized
by
potent
activity
and
tissue
permeability,
offer
promising
approach
overcome
challenges
posed
biofilms.
By
disrupting
biofilm
architecture,
inhibiting
bacterial
growth,
enhancing
detection
through
nuclear-based,
fluorescence-based,
nanobased
techniques,
AMPs
provide
multifaceted
strategy.
highlights
recent
advancements,
approaches,
strategies
peptide
research,
examining
both
diagnostic
therapeutic
agents.
It
also
addresses
key
outlines
future
directions
for
optimizing
peptide-based
therapies.
overcoming
these
refining
design,
we
can
unlock
full
combating
infections,
paving
way
development
solutions
tackle
diseases
improve
global
health.
